Zobrazeno 1 - 10
of 303
pro vyhledávání: '"Antony, Galione"'
Autor:
Thamali Ayagama, Philip D. Charles, Samuel J. Bose, Barry Boland, David A. Priestman, Daniel Aston, Georgina Berridge, Roman Fischer, Adam P. Cribbs, Qianqian Song, Gary R. Mirams, Kwabena Amponsah, Lisa Heather, Antony Galione, Neil Herring, Holger Kramer, Rebecca A. Capel, Frances M. Platt, Ulrich Schotten, Sander Verheule, Rebecca A.B. Burton
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109609- (2024)
Summary: Endolysosomes (EL) are known for their role in regulating both intracellular trafficking and proteostasis. EL facilitate the elimination of damaged membranes, protein aggregates, membranous organelles and play an important role in calcium si
Externí odkaz:
https://doaj.org/article/5ce7e4802b624eb9b2d4d4afc4a88738
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S765- (2023)
Externí odkaz:
https://doaj.org/article/366ddc4794b445b2b422247be4a03342
Autor:
Grant C. Churchill, Michael Strupp, Cailley Factor, Tatiana Bremova-Ertl, Mallory Factor, Marc C. Patterson, Frances M. Platt, Antony Galione
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Small changes to molecules can have profound effects on their pharmacological activity as exemplified by the addition of the two-carbon acetyl group to make drugs more effective by enhancing their pharmacokinetic or pharmacodynamic propertie
Externí odkaz:
https://doaj.org/article/8ec79fdb99cd4403ad6f39300b2c4f15
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Pancreatic β-cells release insulin upon a rise in blood glucose. The precise mechanisms of stimulus-secretion coupling, and its failure in Diabetes Mellitus Type 2, remain to be elucidated. The consensus model, as well as a class of current
Externí odkaz:
https://doaj.org/article/9045c5c0e3dc4eeb89bc5c8eecf10a5d
Autor:
Aarti Jagannath, Norbert Varga, Robert Dallmann, Gianpaolo Rando, Pauline Gosselin, Farid Ebrahimjee, Lewis Taylor, Dragos Mosneagu, Jakub Stefaniak, Steven Walsh, Teele Palumaa, Simona Di Pretoro, Harshmeena Sanghani, Zeinab Wakaf, Grant C. Churchill, Antony Galione, Stuart N. Peirson, Detlev Boison, Steven A. Brown, Russell G. Foster, Sridhar R. Vasudevan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Sleep pressure and circadian rhythms influence one another. However, the regulatory mechanisms are unclear. Here, the authors show that adenosine A1/A2A receptor antagonists, such as caffeine, shift circadian rhythms and enhance the effects of light,
Externí odkaz:
https://doaj.org/article/fe29a732cf334692a98923abc1d068d8
Autor:
Oscar C. W. Chen, Alexandria Colaco, Lianne C. Davis, Fedir N. Kiskin, Nicole Y. Farhat, Anneliese O. Speak, David A. Smith, Lauren Morris, Emily Eden, Patricia Tynan, Grant C. Churchill, Antony Galione, Forbes D. Porter, Frances M. Platt
Publikováno v:
JIMD Reports, Vol 56, Iss 1, Pp 46-57 (2020)
Abstract Niemann‐Pick disease type C (NPC) is a neurodegenerative lysosomal storage disorder caused by mutations in either NPC1 (95% of cases) or NPC2. Reduced late endosome/lysosome calcium (Ca2+) levels and the accumulation of unesterified choles
Externí odkaz:
https://doaj.org/article/0e1a6412d2a14de1a7841b940a26ea33
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-16 (2020)
Abstract Background Two-pore channels (TPCs) release Ca2+ from acidic intracellular stores and are implicated in a number of diseases, but their role in development is unclear. The social amoeba Dictyostelium discoideum proliferates as single cells t
Externí odkaz:
https://doaj.org/article/fa8578a9d7864780b2d1b889c50d0c79
Autor:
Thamali Ayagama, Samuel J. Bose, Rebecca A. Capel, David A. Priestman, Georgina Berridge, Roman Fischer, Antony Galione, Frances M. Platt, Holger Kramer, Rebecca A.B. Burton
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102949- (2021)
Summary: The importance of lysosomes in cardiac physiology and pathology is well established, and evidence for roles in calcium signaling is emerging. We describe a label-free proteomics method suitable for small cardiac tissue biopsies based on dens
Externí odkaz:
https://doaj.org/article/89182a514c6548768b6697ff55f84605
Autor:
Grishma Desai, Gurumurthy Ramachandran, Emanuel Goldman, William Esposito, Antony Galione, Altaf Lal, Toni K. Choueiri, Andre Fay, William Jordan, Donald W. Schaffner, Jack Caravanos, Etienne Grignard, Gediminas Mainelis
Publikováno v:
Environmental Science & Technology. 57:4231-4240
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45c1ae8c67426bcbb32bbba6fcbb0319
https://doi.org/10.1021/acs.est.2c08632
https://doi.org/10.1021/acs.est.2c08632
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0229585 (2020)
The enantiomers of many chiral drugs not only exhibit different pharmacological effects in regard to targets that dictate therapeutic and toxic effects, but are also handled differently in the body due to pharmacokinetic effects. We investigated the
Externí odkaz:
https://doaj.org/article/0e87beed725544e19b245b937315a59e