Accelerated Repurposing and Drug Development of Pulmonary Hypertension Therapies for COVID-19 Treatment Using an AI-Integrated Biosimulation Platform.

Autor: Chakravarty K; VeriSIM Life, 1 Sansome Street, Suite 3500, San Francisco, CA 94104, USA., Antontsev VG; VeriSIM Life, 1 Sansome Street, Suite 3500, San Francisco, CA 94104, USA., Khotimchenko M; VeriSIM Life, 1 Sansome Street, Suite 3500, San Francisco, CA 94104, USA., Gupta N; VeriSIM Life, 1 Sansome Street, Suite 3500, San Francisco, CA 94104, USA., Jagarapu A; VeriSIM Life, 1 Sansome Street, Suite 3500, San Francisco, CA 94104, USA., Bundey Y; VeriSIM Life, 1 Sansome Street, Suite 3500, San Francisco, CA 94104, USA., Hou H; VeriSIM Life, 1 Sansome Street, Suite 3500, San Francisco, CA 94104, USA., Maharao N; VeriSIM Life, 1 Sansome Street, Suite 3500, San Francisco, CA 94104, USA., Varshney J; VeriSIM Life, 1 Sansome Street, Suite 3500, San Francisco, CA 94104, USA.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2021 Mar 29; Vol. 26 (7). Date of Electronic Publication: 2021 Mar 29.

Glycosyltransferase ST6GAL1 contributes to the regulation of pluripotency in human pluripotent stem cells.

Autor: Wang YC; Department of Pharmaceutical Sciences, The University of North Texas Health Science Center, Fort Worth, Texas, USA.; The Scripps Research Institute, La Jolla, California, USA.; Center for Regenerative Medicine, The Scripps Research Institute, La Jolla, California, USA., Stein JW; The Scripps Research Institute, La Jolla, California, USA.; Center for Regenerative Medicine, The Scripps Research Institute, La Jolla, California, USA., Lynch CL; The Scripps Research Institute, La Jolla, California, USA.; Center for Regenerative Medicine, The Scripps Research Institute, La Jolla, California, USA., Tran HT; The Scripps Research Institute, La Jolla, California, USA.; Center for Regenerative Medicine, The Scripps Research Institute, La Jolla, California, USA., Lee CY; The Scripps Research Institute, La Jolla, California, USA.; Center for Regenerative Medicine, The Scripps Research Institute, La Jolla, California, USA., Coleman R; The Scripps Research Institute, La Jolla, California, USA.; Center for Regenerative Medicine, The Scripps Research Institute, La Jolla, California, USA., Hatch A; Northeastern University Boston, USA., Antontsev VG; Northeastern University Boston, USA., Chy HS; CSIRO, Flagship, Cell Biology Group, Clayton, Victoria, Australia.; Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia., O'Brien CM; CSIRO, Flagship, Cell Biology Group, Clayton, Victoria, Australia.; Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia., Murthy SK; Northeastern University Boston, USA.; Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, USA., Laslett AL; CSIRO, Flagship, Cell Biology Group, Clayton, Victoria, Australia.; Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia., Peterson SE; The Scripps Research Institute, La Jolla, California, USA.; Center for Regenerative Medicine, The Scripps Research Institute, La Jolla, California, USA., Loring JF; The Scripps Research Institute, La Jolla, California, USA.; Center for Regenerative Medicine, The Scripps Research Institute, La Jolla, California, USA.

Publikováno v: Scientific reports [Sci Rep] 2015 Aug 25; Vol. 5, pp. 13317. Date of Electronic Publication: 2015 Aug 25.

SARS-CoV-2 and Hypertension: Evidence Supporting Invasion into the Brain Via Baroreflex Circuitry and the Role of Imbalanced Renin-Angiotensin-Aldosterone-System.

Autor: Oliveira, Kellysson Bruno¹, Melo, Igor Santana de¹, Silva, Bianca Rodrigues Melo da¹, Oliveira, Keylla Lavínia da Silva¹, Sabino-Silva, Robinson², Anhezini, Lucas³, Katayama, Pedro Lourenco⁴, Santos, Victor Rodrigues⁵, Shetty, Ashok K⁶, Castro, Olagide Wagner de¹ olagidewww@gmail.com

Publikováno v: Neuroscience Insights. 2/1/2023, p1-10. 10p.

An AI Approach to Generating MIDD Assets Across the Drug Development Continuum.

Autor: Barrett, Jeffrey S, Goyal, Rahul K, Gobburu, Jogarao, Baran, Szczepan, Varshney, Jyotika

Publikováno v: AAPS Journal; Jul2023, Vol. 25 Issue 4, p1-14, 14p

Regulation of ST6GAL1 sialyltransferase expression in cancer cells.

Autor: Dorsett, Kaitlyn A, Marciel, Michael P, Hwang, Jihye, Ankenbauer, Katherine E, Bhalerao, Nikita, Bellis, Susan L

Publikováno v: Glycobiology; May2021, Vol. 31 Issue 5, p530-539, 10p