Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Antonius W M Boersma"'
Autor:
Katharina Uhr, Wendy J C Prager-van der Smissen, Anouk A J Heine, Bahar Ozturk, Marijn T M van Jaarsveld, Antonius W M Boersma, Agnes Jager, Erik A C Wiemer, Marcel Smid, John A Foekens, John W M Martens
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216400 (2019)
MicroRNAs (miRNAs) regulate gene expression post-transcriptionally. In this way they might influence whether a cell is sensitive or resistant to a certain drug. So far, only a limited number of relatively small scale studies comprising few cell lines
Externí odkaz:
https://doaj.org/article/fc78a49c90764f2c95e440af96288a6a
Autor:
John A. Foekens, Agnes Jager, John W.M. Martens, Anouk A. J. Heine, Marijn T.M. van Jaarsveld, Erik A.C. Wiemer, Wendy J. C. Prager-van der Smissen, Antonius W. M. Boersma, Bahar Ozturk, Marcel Smid, Katharina Uhr
Publikováno v:
PLoS ONE
PLoS One (online), 14(5):e0216400. Public Library of Science
PLoS ONE, Vol 14, Iss 5, p e0216400 (2019)
PLoS One (online), 14(5):e0216400. Public Library of Science
PLoS ONE, Vol 14, Iss 5, p e0216400 (2019)
MicroRNAs (miRNAs) regulate gene expression post-transcriptionally. In this way they might influence whether a cell is sensitive or resistant to a certain drug. So far, only a limited number of relatively small scale studies comprising few cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bc8283e13a4cb3f1dde3634be0ce66
https://doi.org/10.1371/journal.pone.0216400
https://doi.org/10.1371/journal.pone.0216400
Autor:
Jean-Michel Coindre, Caroline M.M. Gits, Stefan Sleijfer, Cornelis Verhoef, Michael A. den Bakker, Antonius W. M. Boersma, Marcel Smid, Frédéric Chibon, Ron H.J. Mathijssen, Moniek B E Jonkers, Erik A.C. Wiemer, Jaap Verweij, Patricia F. van Kuijk, Wilfred F. J. van IJcken
Publikováno v:
International Journal of Cancer. 135:348-361
Liposarcomas are rare, heterogeneous and malignant tumors that can be divided into four histological subtypes with different characteristics and clinical behavior. Treatment consists of surgery in combination with systemic chemotherapy, but neverthel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02fd8e6b91c92db4e75803d37b791c4f
https://doi.org/10.1002/ijc.28694
https://doi.org/10.1002/ijc.28694
Autor:
Steven Van Laere, Wilfred F. J. van IJcken, Ron H.J. Mathijssen, Marijn T.M. van Jaarsveld, Maikel D. Wouters, Erik A.C. Wiemer, Antonius W. M. Boersma, John W.M. Martens, Jan H.J. Hoeijmakers, Joris Pothof, Marcel Smid
Publikováno v:
Molecular Oncology, 8(3), 458-468. John Wiley & Sons Ltd.
The DNA damage response (DDR) is activated upon DNA damage and prevents accumulation of mutations and chromosomal rearrangements, both driving carcinogenesis. Tumor cells often have defects in the DDR, which in combination with continuous cell prolif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8f6f38ed5f3604b265501ab314824b
https://hdl.handle.net/1765/62942
https://hdl.handle.net/1765/62942
Autor:
Antonius W. M. Boersma, Erik A.C. Wiemer, M T M van Jaarsveld, P F van Kuijk, Els M.J.J. Berns, Jaap Verweij, W F J van IJcken, Ignace Vergote, Ron H.J. Mathijssen, Evelyn Despierre, Joris Pothof, Jozien Helleman
Publikováno v:
Oncogene, 32(36), 4284-4293. Nature Publishing Group
Epithelial ovarian cancer is the most lethal gynecological malignancy in the Western world. A major impediment for the successful treatment is the development of drug resistance. The molecular processes that contribute to resistance have been extensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511bb9b2a82f5cb8e440a7008897203c
https://pure.eur.nl/en/publications/a66d0a7a-884d-4bd9-beac-d41fc6a0d5d9
https://pure.eur.nl/en/publications/a66d0a7a-884d-4bd9-beac-d41fc6a0d5d9
Autor:
Erik A.C. Wiemer, Patrick Schöffski, Antonius W. M. Boersma, Stefan Sleijfer, Caroline M.M. Gits, Ron H.J. Mathijssen, Moniek B E Jonkers, W F J van IJcken, Agnieszka Wozniak, Piotr Rutkowski, P F van Kuijk, Raf Sciot, Jaap Verweij, Takahiro Taguchi, Maria Debiec-Rychter
Publikováno v:
British Journal of Cancer, 109(6), 1625-1635. Nature Publishing Group
British Journal of Cancer
British Journal of Cancer
BACKGROUND: Gastrointestinal stromal tumours (GIST) are characterised by high expression of KIT and ETV1, which cooperate in GIST oncogenesis. Our aim was to identify microRNAs that are deregulated in GIST, have a role in GIST pathogenesis, and could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5604776771cd0c76dd0fe1500059884a
https://doi.org/10.1038/bjc.2013.483
https://doi.org/10.1038/bjc.2013.483
Autor:
Antonius W. M. Boersma, Michelle J. Nyhan, Tracey R. O’Donovan, Sharon L. McKenna, Erik A.C. Wiemer
Publikováno v:
BMC Cancer, 16:101. BioMed Central Ltd.
BMC Cancer
BMC Cancer
Background: Successful treatment of oesophageal cancer is hampered by recurrent drug resistant disease. We have previously demonstrated the importance of apoptosis and autophagy for the recovery of oesophageal cancer cells following drug treatment. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a54d64b89060d6f1e436fed92dcb68
https://doi.org/10.1186/s12885-016-2123-6
https://doi.org/10.1186/s12885-016-2123-6
Autor:
Ron H. J. Mathijssen, Sandra Segeletz, Takahiro Taguchi, Antonius W. M. Boersma, Herman Burger, Alex Sparreboom, Erik A.C. Wiemer, Alexander T. den Dekker, Maria Debiec-Rychter, Peter de Bruijn, Stefan Sleijfer
Publikováno v:
Molecular Pharmacology, 88(3), 477-487. American Society for Pharmacology and Experimental Therapeutics
The intracellular uptake and retention (IUR) of imatinib is reported to be controlled by the influx transporter SLC22A1 (organic cation transporter 1). We recently hypothesized that alternative uptake and/or retention mechanisms exist that determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11013a9da40233e0c7ca46211b44cdf
https://pure.eur.nl/en/publications/bcd5fb1c-e786-4a63-bd15-f1fdd24531bc
https://pure.eur.nl/en/publications/bcd5fb1c-e786-4a63-bd15-f1fdd24531bc
Publikováno v:
Molecular Pharmacology, 61, 659-666. American Society for Pharmacology and Experimental Therapeutics
The therapeutic potential of the highly active anticancer agent cisplatin is severely limited by the occurrence of cellular resistance. A better understanding of the molecular pathways involved in cisplatin-induced cell death could potentially indica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a7c24eed166531f110b08edcd90ba2
https://doi.org/10.1124/mol.61.3.659
https://doi.org/10.1124/mol.61.3.659
Autor:
Antonius W. M. Boersma, Marc Maliepaard, Jaap Verweij, Kees Nooter, Jan H.M. Schellens, Gerrit Stoter, J. Ma
Publikováno v:
Cancer Chemotherapy & Pharmacology, 41, 307-316. Springer-Verlag
The cytotoxicity of cisplatin alone and in combination with topotecan (TPT) or SN-38, two novel topoisomerase I (topo I) inhibitors, was determined in a panel of eight well-characterized human solid-tumor cell lines. Interactions between cisplatin an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661299b1dd6b6291ad0a90512535797e
https://doi.org/10.1007/s002800050744
https://doi.org/10.1007/s002800050744