Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Antonius P A Janssen"'
Autor:
Ming Jiang, Mirjam C. W. Huizenga, Jonah L. Wirt, Janos Paloczi, Avand Amedi, Richard J. B. H. N. van den Berg, Joerg Benz, Ludovic Collin, Hui Deng, Xinyu Di, Wouter F. Driever, Bogdan I. Florea, Uwe Grether, Antonius P. A. Janssen, Thomas Hankemeier, Laura H. Heitman, Tsang-Wai Lam, Florian Mohr, Anto Pavlovic, Iris Ruf, Helma van den Hurk, Anna F. Stevens, Daan van der Vliet, Tom van der Wel, Matthias B. Wittwer, Constant A. A. van Boeckel, Pal Pacher, Andrea G. Hohmann, Mario van der Stelt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Monoacylglycerol lipase (MAGL) regulates endocannabinoid 2-arachidonoylglycerol (2-AG) and eicosanoid signalling. MAGL inhibition provides therapeutic opportunities but clinical potential is limited by central nervous system (CNS)-mediated s
Externí odkaz:
https://doaj.org/article/fdb22352db0b4e3798c8149c29653a5f
Autor:
Xiaoting Li, Hao Chang, Jara Bouma, Laura V. de Paus, Partha Mukhopadhyay, Janos Paloczi, Mohammed Mustafa, Cas van der Horst, Sanjay Sunil Kumar, Lijie Wu, Yanan Yu, Richard J. B. H. N. van den Berg, Antonius P. A. Janssen, Aron Lichtman, Zhi-Jie Liu, Pal Pacher, Mario van der Stelt, Laura H. Heitman, Tian Hua
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Cannabinoid CB2 receptor (CB2R) agonists are investigated as therapeutic agents in the clinic. Here, authors report the discovery of LEI-102, a CB2R agonist, used in conjunction with three other CBR ligands (APD371, HU308, and CP55,940) to investigat
Externí odkaz:
https://doaj.org/article/4a0327fb90ed454caed0f1b796b69018
Autor:
Alexander T. Bakker, Ioli Kotsogianni, Liza Mirenda, Verena M. Straub, Mariana Avalos, Richard J. B. H. N. van den Berg, Bogdan I. Florea, Gilles P. van Wezel, Antonius P. A. Janssen, Nathaniel I. Martin, Mario van der Stelt
Publikováno v:
Journal of the American Chemical Society, 145(2), 1136-1143. American Chemical Society (ACS)
Phenotypic screening is a powerful approach to identify novel antibiotics, but elucidation of the targets responsible for the antimicrobial activity is often challenging in the case of compounds with a polypharmacological mode of action. Here, we sho
Publikováno v:
Israel Journal of Chemistry. 63
Autor:
Mario van der Stelt, Olivier J. M. Béquignon, Gerard J. P. van Westen, Jacob M. A. van Hengst, Hui Deng, Antonius P A Janssen
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 62(17), 7910-7922
Journal of Medicinal Chemistry, 62(17), 7910-7922
Drug discovery programs of covalent irreversible, mechanism-based enzyme inhibitors often focus on optimization of potency as determined by IC50-values in biochemical assays. These assays do not allow the characterization of the binding activity (Ki)
Autor:
Can Araman, Mikkel H. S. Marqvorsen, René E. M. Toes, Marcel Camps, George M.C. Janssen, Ferry Ossendorp, Clarissa R. Nascimento, Gerard J. P. van Westen, Willemijn van der Wulp, G. J. Mirjam Groenewold, Arieke S. B. Kampstra, Thomas Bakkum, Tyrza van Leeuwen, Antonius P A Janssen, Herman S. Overkleeft, Peter A. van Veelen, Sander I. van Kasteren, Bogdan I. Florea, Linda Pieper Pournara
Publikováno v:
RSC Chemical Biology, 2(3), 855-862. Royal Society of Chemistry ({RSC})
Rsc Chemical Biology
RSC Chemical Biology, 2(3), 855-862. ROYAL SOC CHEMISTRY
RSC Chemical Biology
Rsc Chemical Biology
RSC Chemical Biology, 2(3), 855-862. ROYAL SOC CHEMISTRY
RSC Chemical Biology
Proteolysis is fundamental to many biological processes. In the immune system, it underpins the activation of the adaptive immune response: degradation of antigenic material into short peptides and presentation thereof on major histocompatibility com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba3d5912bbcee81d239494de3691466
https://hdl.handle.net/1887/3192759
https://hdl.handle.net/1887/3192759
Autor:
Ozge Gunduz-Cinar, Laura I. Castillo, Antonius P A Janssen, Helma van den Hurk, Marjolein Soethoudt, Andrew Holmes, Resat Cinar, Cristina Miliano, Annelot C. M. van Esbroeck, Colleen M Donovan, Pal Pacher, Elliot D. Mock, Aron H. Lichtman, Alexander T Bakker, Jesse Wat, Matthew W. Buczynski, Anouk M F van der Gracht, Tom van der Wel, Ioli Kotsogianni, Vasudev Kantae, Tiemen J Wendel, Xinyu Di, Thomas Hankemeier, Matthias B. Wittwer, Matthew N. Hill, János Pálóczi, Gavin N. Petrie, Uwe Grether, Joshua K. Park, Andrea Martella, Zoltán Varga, Ming Jiang, Daisuke Ogasawara, Giulia Donvito, Benjamin F. Cravatt, Constant A. A. van Boeckel, Bogdan I. Florea, Mario van der Stelt, Mohammed A. Mustafa
Publikováno v:
Nature Chemical Biology, 16(6), 667-675
Nat Chem Biol
Nat Chem Biol
N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858eb516053df2c6e71eaf7ba6acceef
https://www.nature.com/articles/s41589-020-0528-7
https://www.nature.com/articles/s41589-020-0528-7
Autor:
Antonius P A Janssen, Ferdinando Scavizzi, Hans den Dulk, Barbara Barboni, Nicola Bernabò, Marcello Raspa, Hermen S. Overkleeft, Bogdan I. Florea, Marc P. Baggelaar, Mario van der Stelt, Mauro Maccarrone, Domenico Fazio
Publikováno v:
ACS Chemical Biology
ACS Chemical Biology, 14(10), 2295-2304
ACS Chemical Biology, 14(10), 2295-2304
ABHD2 is a serine hydrolase that belongs to the subgroup of the α,β-hydrolase fold-containing proteins, which is involved in virus propagation, immune response, and fertilization. Chemical tools to selectively modulate the activity of ABHD2 in an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66bf3249c72aff1ac04131fac8a9d087
https://hdl.handle.net/1887/79964
https://hdl.handle.net/1887/79964
Autor:
Roy M. Kreekel, Mario van der Stelt, Hans den Dulk, Thomas Hansen, Eva J. van Rooden, Annelot C. M. van Esbroeck, Antonius P A Janssen, Jeroen D. C. Codée, Richard J. B. H. N. van den Berg
Publikováno v:
Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, 16, 5250-5253. Royal Society of Chemistry ({RSC})
Organic and Biomolecular Chemistry, 16(29), 5250-5253. Royal Society of Chemistry
Van Rooden, E J, Kreekel, R, Hansen, T, Janssen, A P A, Van Esbroeck, A C M, Den Dulk, H, Van Den Berg, R J B H N, Codée, J D C & Van Der Stelt, M 2018, ' Two-step activity-based protein profiling of diacylglycerol lipase ', Organic and Biomolecular Chemistry, vol. 16, no. 29, pp. 5250-5253 . https://doi.org/10.1039/c8ob01499j
Organic and Biomolecular Chemistry, 16, 5250-5253. Royal Society of Chemistry ({RSC})
Organic and Biomolecular Chemistry, 16(29), 5250-5253. Royal Society of Chemistry
Van Rooden, E J, Kreekel, R, Hansen, T, Janssen, A P A, Van Esbroeck, A C M, Den Dulk, H, Van Den Berg, R J B H N, Codée, J D C & Van Der Stelt, M 2018, ' Two-step activity-based protein profiling of diacylglycerol lipase ', Organic and Biomolecular Chemistry, vol. 16, no. 29, pp. 5250-5253 . https://doi.org/10.1039/c8ob01499j
Diacylglycerol lipases (DAGL) produce the endocannabinoid 2-arachidonoylglycerol, a key modulator of neurotransmitter release. Chemical tools that visualize endogenous DAGL activity are desired. Here, we report the design, synthesis and application o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035574af85f78dcf555290e286121fd7
https://hdl.handle.net/1887/73948
https://hdl.handle.net/1887/73948
Autor:
A.C.M. van Esbroeck, Hermen S. Overkleeft, Roy M. Kreekel, M. van der Stelt, R.J.B.H.N. van den Berg, M.J.J. Kohsiek, Antonius P A Janssen, A.M.C.H. van den Nieuwendijk, E.J. van Rooden
Publikováno v:
Chemistry-An Asian Journal, 13(22), 3491-3500
Chemistry-An Asian Journal
Chemistry-An Asian Journal
Diacylglycerol lipases (DAGL) are responsible for the biosynthesis of the endocannabinoid 2‐arachidonoylglycerol. The fluorescent activity‐based probes DH379 and HT‐01 have been previously shown to label DAGLs and to cross‐react with the seri