Výsledky vyhledávání - "Antonios Margaritis"

Non-inferiority evaluation of preservative-free latanoprost/timolol eye drops solution versus preserved latanoprost/timolol eye drops in patients with high intraocular pressure and open-angle glaucoma

Autor: Panos Theodosiadis, Lida Kalantzi, Antonios Margaritis, Ioannis Halkiadakis, Konstantina Soulele, Dimitrios Koufakis, Evgenia Kanonidou, Anastasios Konstas, Constantinos D Georgakopoulos, Vasiliki Dimera, Michael Lygeros, Elias Zintzaras

Publikováno v: Medical Hypothesis, Discovery & Innovation in Ophthalmology. 9

Background: This study aimed to evaluate the non-inferiority and safety of a newly developed preservative-free (PF) multi-dose latanoprost/timolol ophthalmic solution, compared with the benzalkonium chloride (BAK)-preserved fixed combination, in pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f6814f84cba20ab86cba9c42e05037b
https://doi.org/10.51329/mehdiophthal1411

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Preservative-free versus preserved latanoprost eye drops for reducing intraocular pressure: a non-inferiority phase III randomized, multi-center, single-blind, parallel-group controlled trial

Autor: Antonios Margaritis, Vasiliki Dimera, Constantinos D Georgakopoulos, Panos Theodosiadis, Evgenia Kanonidou, Konstantina Soulele, Lida Kalantzi, Dimitrios Koufakis, Elias Zintzaras, Anastasios Konstas, Ioannis Halkiadakis

Publikováno v: Medical Hypothesis, Discovery & Innovation in Ophthalmology. 9

Background: The aim of this study was to test the non-inferiority of preservative-free (PF) latanoprost 50 μg/mL multi-dose ophthalmic solution versus the marketed benzalkonium chloride (BAK)-preserved latanoprost 50 μg/mL ophthalmic solution in pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e93479e62fc08135f84cf08c804b07a1
https://doi.org/10.51329/mehdiophthal1413

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On the usefulness of four in vitro methodologies in screening for product related differences in tacrolimus exposure after oral administration of amorphous solid dispersions with modified release characteristics in the fasted state

Autor: Georgia Tsakiridou, Patrick J. O'Dwyer, Antonios Margaritis, Karl J. Box, Maria Vertzoni, Lida Kalantzi, Christos Reppas

Publikováno v: Journal of Drug Delivery Science and Technology. 69:102990

Objective: To investigate the usefulness of four in vitro methodologies in screening for product related differences in tacrolimus exposure after oral administration of amorphous solid dispersions with modified release characteristics in the fasted s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952bf21c2d1d3431baa163236d9b6d1f
https://doi.org/10.1016/j.jddst.2021.102990

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The control of hyperhomocysteinemia through thiol exchange mechanisms by mesna

Autor: Lucia Coppo, Domenico Summa, Monica Ulivelli, Danila Di Giuseppe, Simona Frosali, Paolo Di Simplicio, Antonios Margaritis, Raffaella Priora, Sabina Bartalini

Publikováno v: Amino Acids. 46:429-439

In hyperhomocysteinemic patients, after reaction with homocysteine-albumin mixed disulfides (HSS-ALB), mesna (MSH) forms the mixed disulfide with Hcy (HSSM) which can be removed by renal clearance, thus reducing the plasma concentration of total homo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6053cc9186d921727f73f09e60e42a6
https://doi.org/10.1007/s00726-013-1636-4

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In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways

Autor: Lucia Coppo, G. P. Pessina, Domenico Summa, Paolo Di Simplicio, Danila Di Giuseppe, Antonios Margaritis, Carlo Aldinucci, Raffaella Priora, Simona Frosali, Anna Di Stefano

Publikováno v: Pharmacological Research. 64:289-297

Three different NO donors, S-nitrosoglutathione (GSNO), sodium nitroprusside (SNP) and 3-morpholino-sydnonimine hydrochloride (SIN-1) were used in order to investigate mechanisms of platelet inhibition through cGMP-dependent and -independent pathways

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed69fbbea27d33e06d2051bef19a102
https://doi.org/10.1016/j.phrs.2011.03.014

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The control of S-thiolation by cysteine via gamma-glutamyltranspeptidase and thiol exchanges in erythrocytes and plasma of diamide-treated rats

Autor: Lucia Coppo, Paolo Di Simplicio, Simona Frosali, Antonios Margaritis, Raffaella Priora, Jongyun Heo, Domenico Summa, Danila Di Giuseppe

Publikováno v: Toxicology and Applied Pharmacology. 242:333-343

Protein thiol modifications including cysteinylation (CSSP) and glutathionylation (GSSP) in erythrocytes of rat treated with diamide have been reported, but mechanism and origin of CSSP formation are unknown. Experiments were performed to relate CSSP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066ea817be1eaaeedd5b5f8b942c9745
https://doi.org/10.1016/j.taap.2009.11.003

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A structurally driven analysis of thiol reactivity in mammalian albumins

Autor: Simone Cirri, Simona Frosali, Andrea Bernini, Domenico Summa, Neri Niccolai, Danila Di Giuseppe, Paolo Di Simplicio, Matteo De Chiara, Antonios Margaritis, Raffaella Priora, Ottavia Spiga, Vincenzo Venditti

Understanding the structural basis of protein redox activity is still an open question. Hence, by using a structural genomics approach, different albumins have been chosen to correlate protein structural features with the corresponding reaction rates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748b2381b0c96fb2a75ca0869196845f
http://hdl.handle.net/11365/12377

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The role of protein sulfhydryl groups and protein disulfides of the platelet surface in aggregation processes involving thiol exchange reactions

Autor: Antonios Margaritis, Danila Di Giuseppe, Raffaella Priora, Anna Di Stefano, Domenico Summa, Paolo Di Simplicio, Lucia Coppo, Simona Frosali

Publikováno v: Pharmacological research. 63(1)

Blood platelets are central to haemostasis and platelet aggregation is considered to be a direct index of platelet function. Although protein disulfides (PSSP) are structural components of most proteins, current evidence suggests that PSSP work toget

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801aae79086020aa818fe3fa86a52cce
https://pubmed.ncbi.nlm.nih.gov/20883787

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Regulation of redox forms of plasma thiols by albumin in multiple sclerosis after fasting and methionine loading test

Autor: Antonios Margaritis, Sabina Bartalini, Monica Ulivelli, Raffaella Priora, Alfonso Cerase, Stefano Passero, Simona Frosali, Stefania Battistini, Danila Di Giuseppe, Paolo Di Simplicio, Domenico Summa

Increases in plasma concentrations of total homocysteine (tHcy) have recently been reported in multiple sclerosis (MS) as the alteration of the methionine cycle for the onset of autoimmune diseases. Homocysteine (Hcy) and cysteine (Cys) are generated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bec350fd9bcd97f4e9938d5ae4690fb
http://hdl.handle.net/11365/40495

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