Pinpointing a Mechanistic Switch Between Ketoreduction and 'Ene' Reduction in Short‐Chain Dehydrogenases/Reductases

Autor: Antonios Lygidakis, Vijaykumar Karuppiah, Robin Hoeven, Aisling Ní Cheallaigh, David Leys, John M. Gardiner, Helen S. Toogood, Nigel S. Scrutton

Publikováno v: Angewandte Chemie (Weinheim an Der Bergstrasse, Germany)
Angewandte Chemie (International Ed. in English)
Lygidakis, A, Karuppiah, V, Hoeven, R, Ni Cheallaigh, A, Leys, D, Gardiner, J, Toogood, H & Scrutton, N 2016, ' Pinpointing a mechanistic switch between ketoreduction and ‘ene’-reduction in short chain dehydrogenases/reductases ', Angewandte Chemie, vol. 55, no. 33, pp. 9596-9600 . https://doi.org/10.1002/anie.201603785

Three enzymes of the Mentha essential oil biosynthetic pathway are highly homologous, namely the ketoreductases (−)‐menthone:(−)‐menthol reductase and (−)‐menthone:(+)‐neomenthol reductase, and the “ene” reductase isopiperitenone re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc61db01f49c59e68705bf86df723c3
http://europepmc.org/articles/PMC4988499

Enzymatic Menthol Production: One-Pot Approach Using Engineered Escherichia coli

Autor: Helen S, Toogood, Aisling, Ní Cheallaigh, Shirley, Tait, David J, Mansell, Adrian, Jervis, Antonios, Lygidakis, Luke, Humphreys, Eriko, Takano, John M, Gardiner, Nigel S, Scrutton

Publikováno v: ACS synthetic biology. 4(10)

Menthol isomers are high-value monoterpenoid commodity chemicals, produced naturally by mint plants, Mentha spp. Alternative clean biosynthetic routes to these compounds are commercially attractive. Optimization strategies for biocatalytic terpenoid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aa7a748e8db72c54d1bd9b992dcbb97c
https://pubmed.ncbi.nlm.nih.gov/26017480