Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Antonios Fikatas"'
Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors
Autor:
Shenghua Gao, Letian Song, Hongtao Xu, Antonios Fikatas, Merel Oeyen, Steven De Jonghe, Fabao Zhao, Lanlan Jing, Dirk Jochmans, Laura Vangeel, Yusen Cheng, Dongwei Kang, Johan Neyts, Piet Herdewijn, Dominique Schols, Peng Zhan, Xinyong Liu
Publikováno v:
Molecules, Vol 28, Iss 1, p 160 (2022)
The Coronavirus Disease 2019 (COVID-19) and dengue fever (DF) pandemics both remain to be significant public health concerns in the foreseeable future. Anti-SARS-CoV-2 drugs and vaccines are both indispensable to eliminate the epidemic situation. Her
Externí odkaz:
https://doaj.org/article/89b6753f327840d6a40932bf3754e640
Autor:
Antonios Fikatas, Jonas Dehairs, Sam Noppen, Jordi Doijen, Frank Vanderhoydonc, Eef Meyen, Johannes V. Swinnen, Christophe Pannecouque, Dominique Schols
Publikováno v:
Viruses, Vol 13, Iss 12, p 2363 (2021)
To date, no vaccines or antivirals are available against Zika virus (ZIKV). In addition, the mechanisms underlying ZIKV-associated pathogenesis of the central nervous system (CNS) are largely unexplored. Getting more insight into the cellular pathway
Externí odkaz:
https://doaj.org/article/2f17693abf364f7692f6a11db31292f6
Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors
Autor:
Shenghua Gao, Letian Song, Hongtao Xu, Antonios Fikatas, Merel Oeyen, Steven De Jonghe, Fabao Zhao, Lanlan Jing, Dirk Jochmans, Laura Vangeel, Yusen Cheng, Dongwei Kang, Johan Neyts, Piet Herdewijn, Dominique Schols, Peng Zhan, Xinyong Liu
Publikováno v:
Molecules; Volume 28; Issue 1; Pages: 160
The Coronavirus Disease 2019 (COVID-19) and dengue fever (DF) pandemics both remain to be significant public health concerns in the foreseeable future. Anti-SARS-CoV-2 drugs and vaccines are both indispensable to eliminate the epidemic situation. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dab3f9b3c3f2ed8cbf75985fbb973cc
https://lirias.kuleuven.be/handle/20.500.12942/711110
https://lirias.kuleuven.be/handle/20.500.12942/711110
Autor:
Eef Meyen, Jordi Doijen, Dominique Schols, Antonios Fikatas, Jonas Dehairs, Christophe Pannecouque, Sam Noppen, Frank Vanderhoydonc, Johannes V. Swinnen
Publikováno v:
Viruses
Viruses; Volume 13; Issue 12; Pages: 2363
Viruses, Vol 13, Iss 2363, p 2363 (2021)
Viruses; Volume 13; Issue 12; Pages: 2363
Viruses, Vol 13, Iss 2363, p 2363 (2021)
To date, no vaccines or antivirals are available against Zika virus (ZIKV). In addition, the mechanisms underlying ZIKV-associated pathogenesis of the central nervous system (CNS) are largely unexplored. Getting more insight into the cellular pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0291124a68d66e327e26633825abff48
http://europepmc.org/articles/PMC8708812
http://europepmc.org/articles/PMC8708812
Autor:
Philippe Lemey, Dominique Schols, Peter Vervaeke, Antonios Fikatas, Liana E. Kafetzopoulou, Eef Meyen, Sergi Ordeix, Mercedes Amat, Ine Boonen, Núria Llor, Christophe Pannecouque, Magda Bletsa
Publikováno v:
Antimicrob Agents Chemother
Here, we identified a novel class of compounds which demonstrated good antiviral activity against dengue and Zika virus infection. These derivatives constitute intermediates in the synthesis of indole (ervatamine-silicine) alkaloids and share a tetra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47ef63ef0e7281e1408142f500dce3c
https://pubmed.ncbi.nlm.nih.gov/34001508
https://pubmed.ncbi.nlm.nih.gov/34001508
Autor:
Bram Vrancken, Joëlle Goüy de Bellocq, Josef Bryja, Frederik Van de Perre, Philippe Lemey, Elke Wollants, Sylvestre Gambalemoke Mbalitini, Magda Bletsa, Jana Těšíková, Yonas Meheretu, Sophie Gryseels, Yiqiao Li, Sebastian Lequime, Oliver G. Pybus, Benjamin Dudu Akaibe, Marc Van Ranst, Jan Felix Drexler, Natalie Van Houtte, Herwig Leirs, Antonios Fikatas, Rhodes H. Makundi, Ine Boonen, Erik Verheyen, Anne Laudisoit
Publikováno v:
Virus Evolution
Virus evolution
Virus evolution
Hepatitis C virus (HCV; genus Hepacivirus) represents a major public health problem, infecting about three per cent of the human population. Because no animal reservoir carrying closely related hepaciviruses has been identified, the zoonotic origins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e368a9cbcbe8a396de054f4d0c472f2d
http://europepmc.org/articles/PMC8242229
http://europepmc.org/articles/PMC8242229
Autor:
Sylvestre Gambalemoke Mbalitini, Jana Těšíková, Jan Felix Drexler, Josef Bryja, Ine Boonen, Elke Wollants, Bram Vrancken, Benjamin Dudu Akaibe, Yiqiao Li, Natalie Van Houtte, Sophie Gryseels, Magda Bletsa, Sebastian Lequime, Yonas Meheretu, Marc Van Ranst, Joëlle Goüy de Bellocq, Philippe Lemey, Herwig Leirs, Rhodes H. Makundi, Anne Laudisoit, Frederik Van de Perre, Antonios Fikatas, Erik Verheyen
Hepatitis C virus (HCV; genus Hepacivirus) represents a major public health problem, infecting about 3 % of the human population (± 185,000,000 people). Because no plausible animal reservoir carrying closely related hepaciviruses has been identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0745675678b118acb3644b5670e306f8
https://doi.org/10.1101/2020.10.09.332932
https://doi.org/10.1101/2020.10.09.332932
Autor:
Dominique Schols, Antonios Fikatas, Peter Vervaeke, Olaia Martí-Marí, María-José Camarasa, Christophe Pannecouque, Belén Martínez-Gualda, Eef Meyen, Sam Noppen, Ana San-Félix
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Antimicrob Agents Chemother
instname
Antimicrob Agents Chemother
Here, we report a class of tryptophan trimers and tetramers that inhibit (at low micromolar range) dengue and Zika virus infection in vitro. These compounds (AL family) have three or four peripheral tryptophan moieties directly linked to a central sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1ce8518bff8dd97413e176db78ca39
https://doi.org/10.1128/aac.02130-19
https://doi.org/10.1128/aac.02130-19
Autor:
Magda Bletsa, Antonios Fikatas, Yiqiao Li, Sophie Gryseels, Jan Felix Drexler, Philippe Lemey
This protocol can be used for total RNA purification from tissue samples. It includes an intermediate on-column DNase treatment, which results in higher RNA yield and purity. This method is mainly optimised to obtain hepacivirus RNA extracts for whol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fecd924adc8b4cccbfed00f29927d9b
https://doi.org/10.17504/protocols.io.8ufhwtn
https://doi.org/10.17504/protocols.io.8ufhwtn
Autor:
Elena Eremeeva, Dominique Schols, Elisabetta Groaz, Lia Margamuljana, Antonios Fikatas, Piet Herdewijn, Mikhail Abramov
Publikováno v:
Nucleic Acids Research
Biomedical applications of nucleic acid aptamers are limited by their rapid degradation in biological fluids and generally demand tedious post-selection modifications that might compromise binding. One possible solution to warrant biostability is to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4732eed5ed690be0b7b4e3653e53b6df
http://hdl.handle.net/11577/3369256
http://hdl.handle.net/11577/3369256