Zobrazeno 1 - 10 of 47 pro vyhledávání: '"Antonio Z. Politi"'
1
A quantitative map of nuclear pore assembly reveals two distinct mechanisms
Autor: Shotaro Otsuka, Jeremy O. B. Tempkin, Wanlu Zhang, Antonio Z. Politi, Arina Rybina, M. Julius Hossain, Moritz Kueblbeck, Andrea Callegari, Birgit Koch, Natalia Rosalia Morero, Andrej Sali, Jan Ellenberg
Publikováno v: Nature
SummaryUnderstanding how the nuclear pore complex (NPC) assembles is of fundamental importance to grasp the mechanisms behind its essential function and understand its role during evolution of eukaryotes1–4. While at least two NPC assembly pathways
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b485869426814ab170e3f293ff44229
https://doi.org/10.1038/s41586-022-05528-w
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2
Akademický článek
Absolute quantification of cohesin, CTCF and their regulators in human cells
Autor: Johann Holzmann, Antonio Z Politi, Kota Nagasaka, Merle Hantsche-Grininger, Nike Walther, Birgit Koch, Johannes Fuchs, Gerhard Dürnberger, Wen Tang, Rene Ladurner, Roman R Stocsits, Georg A Busslinger, Béla Novák, Karl Mechtler, Iain Finley Davidson, Jan Ellenberg, Jan-Michael Peters
Publikováno v: eLife, Vol 8 (2019)
The organisation of mammalian genomes into loops and topologically associating domains (TADs) contributes to chromatin structure, gene expression and recombination. TADs and many loops are formed by cohesin and positioned by CTCF. In proliferating ce
Externí odkaz: https://doaj.org/article/b4dd695cfba54d39a1aacd86fcfa079a
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3
Akademický článek
Feedback, Mass Conservation and Reaction Kinetics Impact the Robustness of Cellular Oscillations.
Autor: Katharina Baum, Antonio Z Politi, Bente Kofahl, Ralf Steuer, Jana Wolf
Publikováno v: PLoS Computational Biology, Vol 12, Iss 12, p e1005298 (2016)
Oscillations occur in a wide variety of cellular processes, for example in calcium and p53 signaling responses, in metabolic pathways or within gene-regulatory networks, e.g. the circadian system. Since it is of central importance to understand the i
Externí odkaz: https://doaj.org/article/4a39bf856da5472fbfc6ba2812dbdbfc
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4
Akademický článek
Nuclear pore assembly proceeds by an inside-out extrusion of the nuclear envelope
Autor: Shotaro Otsuka, Khanh Huy Bui, Martin Schorb, M Julius Hossain, Antonio Z Politi, Birgit Koch, Mikhail Eltsov, Martin Beck, Jan Ellenberg
Publikováno v: eLife, Vol 5 (2016)
The nuclear pore complex (NPC) mediates nucleocytoplasmic transport through the nuclear envelope. How the NPC assembles into this double membrane boundary has remained enigmatic. Here, we captured temporally staged assembly intermediates by correlati
Externí odkaz: https://doaj.org/article/e7d3ccf9ec384e3e9334a9fd70344689
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5
Coherent oscillations in balanced neural networks driven by endogenous fluctuations
Autor: Matteo di Volo, Marco Segneri, Alessandro Torcini, Denis S. Goldobin, Antonio Z. Politi
Publikováno v: Chaos (Woodbury N.Y.) 32 (2022): 023120-1–023120-18. doi:10.1063/5.0075751
info:cnr-pdr/source/autori:di Volo, Matteo; Segneri, Marco; Goldobin, Denis S.; Politi, Antonio; Torcini, Alessandro/titolo:Coherent oscillations in balanced neural networks driven by endogenous fluctuations/doi:10.1063%2F5.0075751/rivista:Chaos (Woodbury N.Y.)/anno:2022/pagina_da:023120-1/pagina_a:023120-18/intervallo_pagine:023120-1–023120-18/volume:32
We present a detailed analysis of the dynamical regimes observed in a balanced network of identical Quadratic Integrate-and-Fire (QIF) neurons with a sparse connectivity for homogeneous and heterogeneous in-degree distribution. Depending on the param
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840c0e80956d54f1a6838b2e9d5647c2
http://arxiv.org/abs/2110.09439
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6
Akademický článek
Geometrical and mechanical properties control actin filament organization.
Autor: Gaëlle Letort, Antonio Z Politi, Hajer Ennomani, Manuel Théry, Francois Nedelec, Laurent Blanchoin
Publikováno v: PLoS Computational Biology, Vol 11, Iss 5, p e1004245 (2015)
The different actin structures governing eukaryotic cell shape and movement are not only determined by the properties of the actin filaments and associated proteins, but also by geometrical constraints. We recently demonstrated that limiting nucleati
Externí odkaz: https://doaj.org/article/717d81706d114ab880ec07e52a4d2d4f
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7
Parental genome unification is highly erroneous in mammalian embryos
Autor: Martyn Blayney, Melina Schuh, Andrea Lucas-Hahn, Patrick Aldag, Clara Baker, Heiner Niemann, Antonio Z. Politi, Kay Elder, Tommaso Cavazza
The vast majority of human embryos are aneuploid. Aneuploidy frequently arises during the early mitotic divisions of the embryo, but the origin of this remains elusive. Using bovine embryos as a model for human embryos, we identify an error-prone mec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6accda4c51858e899cfc4379d3ecd3b3
https://doi.org/10.1101/2020.08.27.269779
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8
Dual-spindle formation in zygotes keeps parental genomes apart in early mammalian embryos
Autor: Manuel Eguren, Isabell Schneider, Bianca Nijmeijer, Jan Ellenberg, Lars Hufnagel, Takashi Hiiragi, M. Julia Roberti, Antonio Z. Politi, Judith Reichmann, M. Julius Hossain
Publikováno v: Science
At the beginning of mammalian life, the genetic material from each parent meets when the fertilized egg divides. It was previously thought that a single microtubule spindle is responsible for spatially combining the two genomes and then segregating t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086d559e82878d2e91c259efd10b3409
https://doi.org/10.1126/science.aar7462
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10
Absolute quantification of cohesin, CTCF and their regulators in human cells
Autor: Jan Ellenberg, Jan-Michael Peters, Nike Walther, Wen Tang, Johann Holzmann, Antonio Z. Politi, Kota Nagasaka, Gerhard Dürnberger, Merle Hantsche-Grininger, Bela Novak, Iain F. Davidson, Birgit Koch, Karl Mechtler, Rene Ladurner, Roman R. Stocsits, Georg A. Busslinger, Johannes Fuchs
Publikováno v: eLife
eLife, Vol 8 (2019)
The organisation of mammalian genomes into loops and topologically associating domains (TADs) contributes to chromatin structure, gene expression and recombination. Loops and TADs are formed by cohesin and positioned by CTCF. In proliferating cells,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8a5044d7bfa07d5c3999dc57fd1af6
https://pubmed.ncbi.nlm.nih.gov/31205001
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