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pro vyhledávání: '"Antonio Villalobo"'
Autor:
Antonio Villalobo
Publikováno v:
Biomolecules, Vol 13, Iss 12, p 1739 (2023)
Signaling by calcium ion (Ca2+) plays a prominent role in cell physiology, and these mechanisms are frequently altered in tumor cells. In this review, we consider the interplay of Ca2+ signaling and the functions of the proto-oncogene non-receptor ty
Externí odkaz:
https://doaj.org/article/9b37ab631f7a4cf29a4d752c0be03e2e
Autor:
Antonio Villalobo
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 661 (2023)
Overexpression and mutations of the epidermal growth factor receptor (EGFR/ErbB1/HER1) and other tyrosine kinase receptors of the ErbB family (ErbB2/HER2, ErbB3/HER3 and ErbB4/HER4) play an essential role in enhancing the proliferation, the migratory
Externí odkaz:
https://doaj.org/article/4332bfa3fa9a461c8879d80489990dae
Publikováno v:
Microorganisms, Vol 10, Iss 10, p 1915 (2022)
Calcium (Ca2+) is a universal second messenger that plays a key role in cellular signaling. However, Ca2+ signals are transduced with the help of Ca2+-binding proteins, which serve as sensors, transducers, and elicitors. Among the collection of these
Externí odkaz:
https://doaj.org/article/697a58013413497e86bd806058d8baf3
Publikováno v:
Heliyon, Vol 6, Iss 5, Pp e03922- (2020)
The growth factor receptor bound protein 7 (Grb7) is a Ca2+-dependent calmodulin (CaM)-binding adaptor protein implicated, among other functions, in cell proliferation, migration and tumor-associated angiogenesis. The goal of this study was to determ
Externí odkaz:
https://doaj.org/article/7d509e639a324d23a45b3ec327d8c33a
Autor:
Antonio Villalobo, Martin W. Berchtold
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 765 (2020)
Calmodulin (CaM) is the principal Ca2+ sensor protein in all eukaryotic cells, that upon binding to target proteins transduces signals encoded by global or subcellular-specific changes of Ca2+ concentration within the cell. The Ca2+/CaM complex as we
Externí odkaz:
https://doaj.org/article/c801a386b28c4a289f6085f44909be1c
Autor:
Silviya R Stateva, Valentina Salas, Gustavo Benaim, Margarita Menéndez, Dolores Solís, Antonio Villalobo
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0120798 (2015)
Calmodulin (CaM) phosphorylated at different serine/threonine and tyrosine residues is known to exert differential regulatory effects on a variety of CaM-binding enzymes as compared to non-phosphorylated CaM. In this report we describe the preparatio
Externí odkaz:
https://doaj.org/article/84a395f124704dc4b171e109a51a48da
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128783 (2015)
Src family non-receptor tyrosine kinases play a prominent role in multiple cellular processes, including: cell proliferation, differentiation, cell survival, stress response, and cell adhesion and migration, among others. And when deregulated by muta
Externí odkaz:
https://doaj.org/article/0ecbe386d7bc4d3eb24e06f173584762
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102523 (2014)
This study analyzes whether the release of nitric oxide (NO) and thromboxane A2 (TXA2) depends on the time lapsed since gonadal function is lost, and their correlation with the proliferation of vascular smooth muscle cells (VSMC) mediated by the epid
Externí odkaz:
https://doaj.org/article/3293d37e4d204b818def2661d78ad54c
Publikováno v:
The Scientific World Journal, Vol 2014 (2014)
Our success in producing an active epidermal growth factor receptor (EGFR) tyrosine kinase in Escherichia coli encouraged us to express the full-length receptor in the same host. Despite its large size, we were successful at producing the full-length
Externí odkaz:
https://doaj.org/article/0dc3abaa12c541149dc006f8b2ec4c22
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 16, Iss 2 (2013)
Signal transduction pathways essential for the survival and viability of the cell and that frequently present aberrant expression or function in tumors are attractive targets for pharmacological intervention in human cancers. In this short review we
Externí odkaz:
https://doaj.org/article/7002557714984e5e8af1de176e935958