Zobrazeno 1 - 10
of 433
pro vyhledávání: '"Antonio Vidal-Puig"'
Autor:
Yasser G. Abdelhafez, Guobao Wang, Siqi Li, Vanessa Pellegrinelli, Abhijit J. Chaudhari, Anthony Ramirez, Fatma Sen, Antonio Vidal-Puig, Labros S. Sidossis, Samuel Klein, Ramsey D. Badawi, Maria Chondronikola
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110559- (2024)
Summary: Brown adipose tissue (BAT) in rodents appears to be an important tissue for the clearance of plasma branched-chain amino acids (BCAAs) contributing to improved metabolic health. However, the role of human BAT in plasma BCAA clearance is poor
Externí odkaz:
https://doaj.org/article/1df32b335621418689408d9e2e57369a
Autor:
Laura Dearden, Isadora C Furigo, Lucas C Pantaleão, L W P Wong, Denise S Fernandez-Twinn, Juliana de Almeida-Faria, Katherine A Kentistou, Maria V Carreira, Guillaume Bidault, Antonio Vidal-Puig, Ken K Ong, John R B Perry, Jose Donato, Susan E Ozanne
Publikováno v:
PLoS Biology, Vol 22, Iss 6, p e3002641 (2024)
In utero exposure to maternal obesity programs increased obesity risk. Animal models show that programmed offspring obesity is preceded by hyperphagia, but the mechanisms that mediate these changes are unknown. Using a mouse model of maternal obesity
Externí odkaz:
https://doaj.org/article/ab9fe1aaf89243808133bb36842e17d9
Autor:
Mei Ying Ng, Zhi Jian Song, Gopalakrishnan Venkatesan, Sergio Rodriguez-Cuenca, James A. West, Shili Yang, Choon Hong Tan, Paul Chi-Lui Ho, Julian L. Griffin, Antonio Vidal-Puig, Marcella Bassetto, Thilo Hagen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract One potential approach for treating obesity is to increase energy expenditure in brown and white adipose tissue. Here we aimed to achieve this outcome by targeting mitochondrial uncoupler compounds selectively to adipose tissue, thus avoidin
Externí odkaz:
https://doaj.org/article/1cb8ab98e74f4ee794d196ce80370f84
Autor:
Yang Yu, Jing Yang, Lixia Zheng, Han Su, Sunrun Cao, Xuehan Jiang, Xiyan Liu, Weiwei Liu, Zhuo Wang, Fang Meng, Hongde Xu, Deliang Wen, Chen Sun, Xiaoyu Song, Antonio Vidal-Puig, Liu Cao
Publikováno v:
Molecular Metabolism, Vol 81, Iss , Pp 101892- (2024)
Background: Myoprotein degradation accelerates in obese individuals, resulting in a decline in muscular mass. Atg7 plays a crucial role in regulating protein stability and function through both autophagy-dependent and independent pathways. As obesity
Externí odkaz:
https://doaj.org/article/bacb92a7a10943a7992bb57a91fa3ef5
Autor:
Jinhong Xu, Le Cui, Jiaqi Wang, Shasha Zheng, Huahua Zhang, Shuo Ke, Xiaoqin Cao, Yanteng Shi, Jing Li, Ke Zen, Antonio Vidal-Puig, Chen-Yu Zhang, Liang Li, Xiaohong Jiang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract During cold exposure, activated brown adipose tissue (BAT) takes up a large amount of circulating glucose to fuel non-shivering thermogenesis and defend against hypothermia. However, little is known about the endocrine function of BAT contro
Externí odkaz:
https://doaj.org/article/92d59ea1028b461a80ee25c72c648be1
Autor:
Abdulbasit Amin, Marina Badenes, Johanna Tüshaus, Érika de Carvalho, Emma Burbridge, Pedro Faísca, Květa Trávníčková, André Barros, Stefania Carobbio, Pedro M. Domingos, Antonio Vidal-Puig, Luís F. Moita, Sarah Maguire, Kvido Stříšovský, Francisco J. Ortega, José Manuel Fernández-Real, Stefan F. Lichtenthaler, Colin Adrain
Publikováno v:
Molecular Metabolism, Vol 73, Iss , Pp 101731- (2023)
Objective: The metalloprotease ADAM17 (also called TACE) plays fundamental roles in homeostasis by shedding key signaling molecules from the cell surface. Although its importance for the immune system and epithelial tissues is well-documented, little
Externí odkaz:
https://doaj.org/article/05555155e4744951844c5a7be30e9720
Autor:
Gabriele Mocciaro, Michael Allison, Benjamin Jenkins, Vian Azzu, Isabel Huang-Doran, Luis Vicente Herrera-Marcos, Zoe Hall, Antonio Murgia, Davies Susan, Mattia Frontini, Antonio Vidal-Puig, Albert Koulman, Julian L. Griffin, Michele Vacca
Publikováno v:
Molecular Metabolism, Vol 73, Iss , Pp 101728- (2023)
Background and objectives: Non-alcoholic fatty liver disease (NAFLD) develops due to impaired hepatic lipid fluxes and is a risk factor for chronic liver disease and atherosclerosis. Lipidomic studies consistently reported characteristic hepatic/VLDL
Externí odkaz:
https://doaj.org/article/96005844129c40cea5356a2f95c916ab
Autor:
Vanessa Pellegrinelli, Elizabeth Figueroa-Juárez, Isabella Samuelson, Mueez U-Din, Sonia Rodriguez-Fdez, Samuel Virtue, Jennifer Leggat, Cankut Çubuk, Vivian J. Peirce, Tarja Niemi, Mark Campbell, Sergio Rodriguez-Cuenca, Joaquin Dopazo Blázquez, Stefania Carobbio, Kirsi A. Virtanen, Antonio Vidal-Puig
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112640- (2023)
Summary: The relevance of extracellular matrix (ECM) remodeling is reported in white adipose tissue (AT) and obesity-related dysfunctions, but little is known about the importance of ECM remodeling in brown AT (BAT) function. Here, we show that a tim
Externí odkaz:
https://doaj.org/article/abc6d1bed4df4ab1bb326033123fcdff
Autor:
Moisés Castellá, Albert Blasco-Roset, Marion Peyrou, Aleix Gavaldà-Navarro, Joan Villarroya, Tania Quesada-López, Leyre Lorente-Poch, Juan Sancho, Florian Szymczak, Anthony Piron, Sonia Rodríguez-Fernández, Stefania Carobbio, Albert Goday, Pere Domingo, Antonio Vidal-Puig, Marta Giralt, Décio L. Eizirik, Francesc Villarroya, Rubén Cereijo
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106847- (2023)
Summary: Adipose tissue from pheochromocytoma patients acquires brown fat features, making it a valuable model for studying the mechanisms that control thermogenic adipose plasticity in humans. Transcriptomic analyses revealed a massive downregulatio
Externí odkaz:
https://doaj.org/article/28b4ea636229492aaaac613396fa4a6a
Autor:
Chao Li, Yuming Feng, Zhenxin Fu, Junjie Deng, Yue Gu, Hanben Wang, Xin Wu, Zhengyun Huang, Yichen Zhu, Zhiwei Liu, Moli Huang, Tao Wang, Shijun Hu, Bing Yao, Yizhun Zeng, Chengji J. Zhou, Steve D. M. Brown, Yi Liu, Antonio Vidal-Puig, Yingying Dong, Ying Xu
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-15 (2022)
Abstract Exploring the functions of human-specific genes (HSGs) is challenging due to the lack of a tractable genetic model system. Testosterone is essential for maintaining human spermatogenesis and fertility, but the underlying mechanism is unclear
Externí odkaz:
https://doaj.org/article/36ba28c778ba4b7e885435790986db95