Development and validation of bioanalytical methods for LNA-i-miR-221 quantification in human plasma and urine by LC-MS/MS

Autor: M. Breda, Antonio Turtoro, Lara Solazzo, Pierosandro Tagliaferri, Alessandro Greco, Maria Teresa Di Martino, Lisa Morbioli, Samantha Franzoni, Pierfrancesco Tassone, Mariamena Arbitrio

Publikováno v: Journal of pharmaceutical and biomedical analysis
(2020): 113451. doi:10.1016/j.jpba.2020.113451
info:cnr-pdr/source/autori:Samantha Franzoni; Lisa Morbioli; Antonio Turtoro; Lara Solazzo; Alessandro Greco; Mariamena Arbitrio; Pierosandro Tagliaferri; Pierfrancesco Tassone; Maria Teresa Di Martino; Massimo Breda;/titolo:Development and validation of bioanalytical methods for LNA-i-miR-221 quantification in human plasma and urine by LC-MS%2FMS/doi:10.1016%2Fj.jpba.2020.113451/rivista:Journal of pharmaceutical and biomedical analysis (Print)/anno:2020/pagina_da:113451/pagina_a:/intervallo_pagine:113451/volume

LNA-i-miR-221, a 13-mer oligonucleotide, has proved favorable efficacy and safety profiles in the preclinical studies, leading to being approved for use in clinical trials by regulatory authorities. The objective of this study was to develop and vali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31814fcdaeadcdbcb949b2eb5741804
https://doi.org/10.1016/j.jpba.2020.113451