Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Antonio Rullan"'
Autor:
Emmanuel C. Patin, Pablo Nenclares, Charleen Chan Wah Hak, Magnus T. Dillon, Anton Patrikeev, Martin McLaughlin, Lorna Grove, Shane Foo, Heba Soliman, Joao P. Barata, Joanna Marsden, Holly Baldock, Jim Gkantalis, Victoria Roulstone, Joan Kyula, Amy Burley, Lisa Hubbard, Malin Pedersen, Simon A. Smith, Eleanor Clancy-Thompson, Alan A. Melcher, Masahiro Ono, Antonio Rullan, Kevin J. Harrington
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The combination of radiotherapy/chemoradiotherapy and immune checkpoint blockade can result in poor outcomes in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). Here, we show that combining ATR inhibition (ATRi)
Externí odkaz:
https://doaj.org/article/e03ce8982c174566b0e3ce1d9a1fbd10
Autor:
Giovanni Giangreco, Antonio Rullan, Yutaka Naito, Dhruva Biswas, Yun-Hsin Liu, Steven Hooper, Pablo Nenclares, Shreerang Bhide, Maggie Chon U Cheang, Probir Chakravarty, Eishu Hirata, Charles Swanton, Alan Melcher, Kevin Harrington, Erik Sahai
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110635- (2024)
Summary: Interactions between cells in the tumor microenvironment (TME) shape cancer progression and patient prognosis. To gain insights into how the TME influences cancer outcomes, we derive gene expression signatures indicative of signaling between
Externí odkaz:
https://doaj.org/article/c33deebabf5c4f759f8aa0451259ec61
Autor:
Pablo Nenclares, Adrian Larkeryd, Floriana Manodoro, Jen Y. Lee, Susan Lalondrelle, Duncan C. Gilbert, Marco Punta, Ben O’Leary, Antonio Rullan, Anguraj Sadanandam, Benny Chain, Alan Melcher, Kevin J. Harrington, Shreerang A. Bhide
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
BackgroundThe effect of chemoradiation on the anti-cancer immune response is being increasingly acknowledged; however, its clinical implications in treatment responses are yet to be fully understood. Human papillomavirus (HPV)-driven malignancies exp
Externí odkaz:
https://doaj.org/article/dfbf765b6f314f468732baee3f145325
Autor:
Takuya Kato, Robert P Jenkins, Stefanie Derzsi, Melda Tozluoglu, Antonio Rullan, Steven Hooper, Raphaël AG Chaleil, Holly Joyce, Xiao Fu, Selvam Thavaraj, Paul A Bates, Erik Sahai
Publikováno v:
eLife, Vol 12 (2023)
Cancers, such as squamous cell carcinoma, frequently invade as multicellular units. However, these invading units can be organised in a variety of ways, ranging from thin discontinuous strands to thick ‘pushing’ collectives. Here we employ an int
Externí odkaz:
https://doaj.org/article/4f843d4c51a4448cb745c3c57242e71f
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Cancer-associated fibroblasts (CAFs) play a fundamental role in the development of cancers and their response to therapy. In recent years, CAFs have returned to the spotlight as researchers work to unpick the mechanisms by which they impact tumour ev
Externí odkaz:
https://doaj.org/article/4934d9fec8fd41889d129dd4a5377a57
Autor:
Charleen M. L. Chan Wah Hak, Antonio Rullan, Emmanuel C. Patin, Malin Pedersen, Alan A. Melcher, Kevin J. Harrington
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Radiotherapy is one of the most effective and frequently used treatments for a wide range of cancers. In addition to its direct anti-cancer cytotoxic effects, ionising radiation can augment the anti-tumour immune response by triggering pro-inflammato
Externí odkaz:
https://doaj.org/article/c017073b207b43c4a7531cc17e430568
Autor:
Yinyin Yuan, Erik Sahai, Carlos E. de Andrea, Antonio Rullan, Sathya Muralidhar, Henrik Failmezger
Pathways enriched for genes downregulated in tumours with high stromal clustering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b20216734bb3fb4b786152c7bee17a
https://doi.org/10.1158/0008-5472.22424784
https://doi.org/10.1158/0008-5472.22424784
Autor:
Yinyin Yuan, Erik Sahai, Carlos E. de Andrea, Antonio Rullan, Sathya Muralidhar, Henrik Failmezger
Additional supplementary material
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2060d6b40ee9130d8972710cef1638b3
https://doi.org/10.1158/0008-5472.22424817.v1
https://doi.org/10.1158/0008-5472.22424817.v1
Autor:
Yinyin Yuan, Erik Sahai, Carlos E. de Andrea, Antonio Rullan, Sathya Muralidhar, Henrik Failmezger
Despite the advent of immunotherapy, metastatic melanoma represents an aggressive tumor type with a poor survival outcome. The successful application of immunotherapy requires in-depth understanding of the biological basis and immunosuppressive mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3ef9453b33bdd4ed2bd14f8f635b15
https://doi.org/10.1158/0008-5472.c.6511866.v1
https://doi.org/10.1158/0008-5472.c.6511866.v1