CB1 receptor autoradiographic characterization of the individual differences in approach and avoidance motivation.

Autor: Daniela Laricchiuta, Maria Luisa Rojo, Antonio Rodriguez-Gaztelumendi, Fabio Ferlazzo, Laura Petrosini, Christopher J Fowler

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e42111 (2012)

Typically, approach behaviour is displayed in the context of moving towards a desired goal, while avoidance behaviour is displayed in the context of moving away from threatening or novel stimuli. In the current research, we detected three sub-populat

Externí odkaz: https://doaj.org/article/e05cefdfca8e47708c38998113fed5f6

Analgesic effects of a novel pH-dependent μ-opioid receptor agonist in models of neuropathic and abdominal pain

Autor: Antonio Rodriguez-Gaztelumendi, Halina Machelska, Christoph Stein, Dominika Labuz, Viola Spahn

Publikováno v: Pain

Supplemental Digital Content is Available in the Text. The newly designed, pH-dependent opioid agonist NFEPP induced analgesia exclusively through peripheral opioid receptors in models of neuropathic and abdominal pain.
Recently, (±)-N-(3-fluor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570b76510d1a8b46d407bd76ab8cda9b
https://doi.org/10.1097/j.pain.0000000000001328

Polyglycerol-opioid conjugate produces analgesia devoid of side effects

Autor: Martin Schmelz, Rainer Haag, Viola Spahn, Dominika Labuz, Christoph Stein, Jan Felix Joseph, Maria Kristina Parr, Sara González-Rodríguez, Xuejiao Zhang, Mohiuddin A. Quadir, Shilpi Gupta, Halina Machelska, Karolina A Walker, Antonio Rodriguez-Gaztelumendi

Publikováno v: eLife, Vol 6 (2017)
eLife
Gonzalez-Rodriguez, S.; Quadir, M.A.; Gupta, S.; Walker, K.A.; Zhang, X.; Spahn, V.; Labuz, D.; Rodriguez-Gaztelumendi, A.; Schmelz, M.; Joseph, J.; Parr, M.K.; Machelska, H.; Haag, R.; Stein, C. : Polyglycerol-opioid conjugate produces analgesia devoid of side effects. In: eLife. Vol. 6 (2017) e27081. (DOI: 10.7554/eLife.27081)

Novel painkillers are urgently needed. The activation of opioid receptors in peripheral inflamed tissue can reduce pain without central adverse effects such as sedation, apnoea, or addiction. Here, we use an unprecedented strategy and report the synt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef41fde35fa1446a1ab10bd551916529
https://doi.org/10.7554/elife.27081

A nontoxic pain killer designed by modeling of pathological receptor conformations

Autor: Viola Spahn, Marcus Weber, Julia Temp, Halina Machelska, Dominika Labuz, Antonio Rodriguez-Gaztelumendi, Christoph Stein, Marco Reidelbach, Vedat Durmaz, G. Del Vecchio, Nicolas Massaly, P. Sabri

Publikováno v: Science (New York, N.Y.). 355(6328)

A pain killer without side effects Opioids are very strong and effective pain killers. However, they also have a range of well-known side effects and can cause addiction. Painful conditions such as inflammation or trauma are often associated with loc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435a07b5c37f18e9897697c1bd90fc77
https://pubmed.ncbi.nlm.nih.gov/28596313

Comparison of the effects of nicotine upon the transcellular electrical resistance and sucrose permeability of human ECV304/rat C6 co-cultures and human CaCo2 cells

Autor: Antonio Rodriguez-Gaztelumendi, Stig O. P. Jacobsson, Malin Alvehus, Therese Andersson

Publikováno v: Toxicology Letters. 207:1-6

It is now well established that nicotine adversely affects the integrity of the blood–brain barrier (BBB). In contrast, nicotine has been reported to increase the transendothelial electrical resist ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8c23fd62a7e19b3cfb8a2d37301f676
https://doi.org/10.1016/j.toxlet.2011.08.014