Výsledky vyhledávání - "Antonio R Parrado"

Akademický článek

Variations in the FRA10AC1 Fragile Site and 15q21 Are Associated with Cerebrospinal Fluid Aβ1-42 Level.

Autor: Qingqin S Li, Antonio R Parrado, Mahesh N Samtani, Vaibhav A Narayan, Alzheimer’s Disease Neuroimaging Initiative

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0134000 (2015)

Proteolytic fragments of amyloid and post-translational modification of tau species in Cerebrospinal fluid (CSF) as well as cerebral amyloid deposition are important biomarkers for Alzheimer's Disease. We conducted genome-wide association study to id

Externí odkaz: https://doaj.org/article/af6a2e86613c4640ab955dc9957e0208

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The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk

Autor: Antonio R. Parrado, Wai-Ki Yip, Tian Liu, Kristina Mullin, Christoph Lange, Dandi Qiao, Lars Bertram, Alfredo Ramirez, Tim Becker, Oliver Peters, Basavaraj Hooli, Rudolph E. Tanzi, Frank Jessen, Johannes T. Roehr

Publikováno v: Neurology 83(15), 1353-1358 (2014). doi:10.1212/WNL.0000000000000855

Objectives: Recently, 2 independent studies reported that a rare missense variant, rs75932628 (R47H), in exon 2 of the gene encoding the “triggering receptor expressed on myeloid cells 2” ( TREM2 ) significantly increases the risk of Alzheimer di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4f012e2bc8ba222593187a470eb1c9
https://doi.org/10.1212/wnl.0000000000000855

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Elucidation of the BACE1 Regulating Factor GGA3 in Alzheimer's Disease

Autor: Annakaisa Haapasalo, Kaisa M.A. Kurkinen, Seppo Helisalmi, Timo Sarajärvi, Kristina Mullin, Rudolph E. Tanzi, Antonio R. Parrado, Teemu Natunen, Hilkka Soininen, Lars Bertram, Petra Mäkinen, Juha-Pekka Pursiheimo, Mikko Hiltunen, Irina Alafuzoff

Publikováno v: Journal of Alzheimer's Disease. 37:217-232

Golgi-localized gamma-ear-containing ADP-ribosylation factor-binding protein (GGA3) is a central regulator of trafficking and degradation of BACE1 (beta-site A beta PP-cleaving enzyme), the rate-limiting enzyme in the production of amyloid-beta (A be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38a1afe6c85c53f61cebccbb9194dd0
https://doi.org/10.3233/jad-130104

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Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

Autor: Basavaraj Hooli, Bradley T. Hyman, Caroline Asselin, Rudolph E. Tanzi, Ana Griciuc, Andrea N. Lesinski, Kristina Mullin, Alberto Serrano-Pozo, Antonio R. Parrado, Se Hoon Choi

Publikováno v: Neuron. 78(4):631-643

SummaryThe transmembrane protein CD33 is a sialic acid-binding immunoglobulin-like lectin that regulates innate immunity but has no known functions in the brain. We have previously shown that the CD33 gene is a risk factor for Alzheimer’s disease (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6fbb6cf86c1ac4b3795f1ab2dfa9cff

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P4‐294: Identification of Genome‐Wide Significant Associations in the Alzheimer’S Disease Sequencing Project Dominican Families with Variants in UGT2B28 , AXIN2 , SYCE1 , BCAT1 , FAM13A , AND DQ594761

Autor: Antonio R. Parrado

Publikováno v: Alzheimer's & Dementia. 12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6de639bcfd3ebc43ba833150937c97df
https://doi.org/10.1016/j.jalz.2016.07.037

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Relevance of the COPI complex for Alzheimer's disease progression in vivo

Autor: Antonio R. Parrado, Marc Flajolet, Lisa Randolph, Paul Greengard, Karima Bettayeb, Dante Varotsis, Suvekshya Aryal, Rudolph E. Tanzi, Jodi Gresack, Basaraj V. Hooli

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 113(19)

Cellular trafficking and recycling machineries belonging to late secretory compartments have been associated with increased Alzheimer's disease (AD) risk. We have shown that coat protein complex I (COPI)-dependent trafficking, an early step in Golgi-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b623dd3c4c910639e2b934789a4ddb
https://pubmed.ncbi.nlm.nih.gov/27114526

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Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3

Autor: Antonio R. Parrado, Johannes T. Roehr, Kristina Mullin, Christoph Lange, Tian Liu, Christine Herold, Lars Bertram, Rudolph E. Tanzi, Basavaraj Hooli, Manuel Mattheisen

Publikováno v: Molecular psychiatry 21(11), 1608-1612 (2016). doi:10.1038/mp.2015.218
Molecular psychiatry
Herold, C, Hooli, B V, Mullin, K, Liu, T, Roehr, J T, Mattheisen, M, Parrado, A R, Bertram, L, Lange, C & Tanzi, R E 2016, ' Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3 ', Molecular Psychiatry . https://doi.org/10.1038/mp.2015.218

The genetic basis of Alzheimer's disease (AD) is complex and heterogeneous. Over 200 highly penetrant pathogenic variants in the genes APP, PSEN1, and PSEN2 cause a subset of early-onset familial AD. On the other hand, susceptibility to late-onset fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc886fd065ebd8500cb0d13ba022f137
https://pub.dzne.de/record/141678

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