Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Antonio Parrado"'
Autor:
Rafael Alfaro, Helios Martínez-Banaclocha, Santiago Llorente, Victor Jimenez-Coll, José Antonio Galián, Carmen Botella, María Rosa Moya-Quiles, Antonio Parrado, Manuel Muro-Perez, Alfredo Minguela, Isabel Legaz, Manuel Muro
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundThe diagnosis of graft rejection in kidney transplantation (KT) patients is made by evaluating the histological characteristics of biopsy samples. The evolution of omics sciences and bioinformatics techniques has contributed to the advancem
Externí odkaz:
https://doaj.org/article/9b5c322549ec47b7bd01a68f516ad962
Publikováno v:
Biochemistry and Biophysics Reports, Vol 16, Iss , Pp 56-61 (2018)
The Th2 cytokine IL-4 triggers a signaling cascade which activates transcription by STAT6. The goals of the present study are to define the transcriptomic response of mouse spleen B cells (mSBC) to IL-4 used as single stimulus, its specificity compar
Externí odkaz:
https://doaj.org/article/2addb309816d480abaf66d670fc24040
Autor:
Isabel Legaz, María Victoria Bernardo, Rafael Alfaro, Helios Martínez-Banaclocha, Jose Antonio Galián, Victor Jimenez-Coll, Francisco Boix, Anna Mrowiec, Diego Salmeron, Carmen Botella, Antonio Parrado, María Rosa Moya-Quiles, Alfredo Minguela, Santiago Llorente, Jesús de la Peña-Moral, Manuel Muro
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Background: Antibody-mediated rejection (AMR) is the major cause of kidney transplant rejection. The donor-specific human leukocyte antigen (HLA) antibody (DSA) response to a renal allograft is not fully understood yet. mTOR complex has been describe
Externí odkaz:
https://doaj.org/article/7b45241411614b1185267facdf56c502
Publikováno v:
Biochemistry and Biophysics Reports, Vol 14, Iss C, Pp 178-181 (2018)
Dedicator-of-cytokinesis (DOCK) proteins are a family of guanine-nucleotide exchange factors (GEF) for Rho GTPases. The DOCK-D homology subfamily comprises DOCK9, DOCK10, and DOCK11. DOCK9 and DOCK11 are GEFs for Cdc42 and induce filopodia, while DOC
Externí odkaz:
https://doaj.org/article/6793a472ef834482baea29b3c47fa7de
Publikováno v:
Antibodies, Vol 10, Iss 3, p 33 (2021)
Dedicator-of-cytokinesis (DOCK), a family of guanine-nucleotide exchange factors (GEFs), comprises four subfamilies, named from A to D. DOCK-D comprises DOCK9, DOCK10, and DOCK11. The GEF activity involves translocation from the cytoplasm to the plas
Externí odkaz:
https://doaj.org/article/e2fed27de01e42be90aa9d3c0076a919
Autor:
Rafael Alfaro, Isabel Legaz, Victor Jimenez-Coll, Jaouad El kaaoui El band, Helios Martínez-Banaclocha, José Antonio Galián, Antonio Parrado, Anna Mrowiec, Carmen Botella, María Rosa Moya-Quiles, Francisco Boix, Jesús de la Peña-Moral, Alfredo Minguela, Santiago Llorente, Manuel Muro
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 13, p 2748 (2021)
Background: The kidney allograft biopsy is considered the gold standard for rejection diagnosis but is invasive and could be indeterminate. Several publications point to the role of miRNA expression in suggesting its involvement in the acceptance or
Externí odkaz:
https://doaj.org/article/c0ef3e622ca84362b8c093599bf46c79
Publikováno v:
Heliyon, Vol 5, Iss 3, Pp e01391- (2019)
DOCK10, a guanine-nucleotide exchange factor (GEF) for Rac1 and Cdc42 Rho GTPases whose expression is induced by interleukin-4 (IL-4) in B cells, is involved in B cell development and function according to recent studies performed in Dock10-knockout
Externí odkaz:
https://doaj.org/article/4184d7be52834f3b903c3c50e35e6e20
Autor:
Antonio Parrado
Publikováno v:
Antibodies, Vol 9, Iss 3, p 27 (2020)
Dedicators of cytokinesis 9 and 11 (DOCK9 and DOCK11) are members of the dedicator of cytokinesis protein family encoding the guanosine nucleotide exchange factors for Rho GTPases. Together with DOCK10, they constitute the DOCK-D or Zizimin subfamily
Externí odkaz:
https://doaj.org/article/4dd29463bdf74e7e9a90c2d896b2284d
Autor:
Natalia Ruiz-Lafuente, María-José Alcaraz-García, Azahara-María García-Serna, Silvia Sebastián-Ruiz, María-Rosa Moya-Quiles, Ana-María García-Alonso, Antonio Parrado
Publikováno v:
Biology Open, Vol 4, Iss 5, Pp 627-635 (2015)
Dock10 is one of the three members of the Dock-D family of Dock proteins, a class of guanine nucleotide exchange factors (GEFs) for Rho GTPases. Its homologs Dock9 and Dock11 are Cdc42 GEFs. Dock10 is required for maintenance of rounded morphology an
Externí odkaz:
https://doaj.org/article/a0a59553a9674171b49caf6e69866c46
Autor:
Natalia Ruiz-Lafuente, María-José Alcaraz-García, Silvia Sebastián-Ruiz, Azahara-María García-Serna, Joaquín Gómez-Espuch, José-María Moraleda, Alfredo Minguela, Ana-María García-Alonso, Antonio Parrado
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124936 (2015)
Interleukin 4 (IL-4) induces B-cell differentiation and survival of chronic lymphocytic leukemia (CLL) cells. MicroRNAs (miRNAs) regulate mRNA and protein expression, and several miRNAs, deregulated in CLL, might play roles as oncogenes or tumor supp
Externí odkaz:
https://doaj.org/article/0bd4564368814877bb43fb39496b32f4