Výsledky vyhledávání - "Antonio Mastrolorenzo"

Development and ex vivo evaluation of 5-aminolevulinic acid-loaded niosomal formulations for topical photodynamic therapy

Autor: Antonio Mastrolorenzo, Marco Bragagni, Andrea Scozzafava, Paola Mura, Claudiu T. Supuran

Publikováno v: Università degli studi di Firenze-IRIS

The objective of this study was the development of a niosomal formulation for improving skin permeation and penetration of 5-aminolevulinic acid (ALA) in the treatment of skin malignancies by photodynamic therapy (PDT). Different niosomal dispersions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c297fbe0309511d14a0206a15af1b7af
https://doi.org/10.1016/j.ijpharm.2015.08.036

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Carbonic anhydrase inhibitors: Inhibition of the β-class enzyme from the pathogenic yeast Candida glabrata with sulfonamides, sulfamates and sulfamides

Autor: Claudiu T. Supuran, Antonio Mastrolorenzo, Fritz A. Mühlschlegel, Worraanong Leewattanapasuk, Daniela Vullo, Clemente Capasso

Publikováno v: Bioorganic & Medicinal Chemistry Letters

The fungal pathogen Candida glabrata encodes for a β-carbonic anhydrase (CA, EC 4.2.1.1), CgNce103, recently discovered. Only anions have been investigated as CgNce103 inhibitors up until now. Here we report the first sulfonamides inhibition study o

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Mycetomatoid infection of the penis by Candida albicans

Autor: Barbara Giomi, Antonio Mastrolorenzo, L Tiradritti, Nicola Decarli, Elisa Margherita Difonzo, Emanuele Maria Cipollini, Rosario Tammaro, Francesca Fabiani Tropeano, Daniele Cammelli, Giuliano Zuccati

Publikováno v: International Journal of Dermatology. 51:1082-1085

Background Mycetoma is generally understood to be a chronic suppurative infection involving the skin and the underlying tissue. Mycetomas may be classified as those produced by true fungi (eumycetoma) versus those due to aerobic bacteria Actinomyceta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aab514cfb7b09089cd772c4a13c45d38
https://doi.org/10.1111/j.1365-4632.2011.05386.x

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Carbonic anhydrase inhibitors. The β-carbonic anhydrases from the fungal pathogens Cryptococcus neoformans and Candida albicans are strongly inhibited by substituted-phenyl-1H-indole-5-sulfonamides

Autor: Antonio Mastrolorenzo, Andrea Scozzafava, Fritz A. Mühlschlegel, Rebecca A. Hall, Alfonso Maresca, Claudiu T. Supuran, Özlen Güzel

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 20:2508-2511

A series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides and 1-({[5-(aminosulfonyl)-3-phenyl-1H-indol-2-yl]carbonyl}amino)-2,4,6 trimethylpyridinium perchlorates possessing various 2-, 3- or 4-substituted phenyl groups with met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce7ab3035b961467902c6ee2db020f1
https://doi.org/10.1016/j.bmcl.2010.02.103

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Update on the development of HIV entry inhibitors

Autor: Antonio Mastrolorenzo, Stefano Rusconi, Alfonso Maresca, Claudiu T. Supuran

Publikováno v: Future HIV Therapy. 2:479-507

HIV fusion and entry are two steps in the viral lifecycle that can be targeted by several classes of antiviral drugs. The discovery of chemokines focused the attention on cellular co-receptors used by the virus for entering cells, and on the various

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e82a5d6158e6191f2869e0b9f22b8f5
https://doi.org/10.2217/17469600.2.5.479

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Inhibitors of HIV-1 Protease: Current State of the Art 10 Years After their Introduction. From Antiretroviral Drugs to Antifungal, Antibacterial and Antitumor Agents Based on Aspartic Protease Inhibitors

Autor: Giuseppe Barbaro, Antonio Mastrolorenzo, Claudiu T. Supuran, Andrea Scozzafava, Stefano Rusconi

Publikováno v: Current Medicinal Chemistry. 14:2734-2748

The introduction of highly active antiretroviral therapy (HAART) in 1996 dramatically changed the course of HIV infection. This therapy involves the use of at least three agents from two distinct classes of antivirals: a protease inhibitor (PI) in co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cecf687b7701b520ee3dfcb2ba31e9
https://doi.org/10.2174/092986707782360141

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Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: Kinetic and X-ray crystallographic studies

Autor: Antonio Mastrolorenzo, Alessio Innocenti, Claudiu T. Supuran, Claudia Temperini, Andrea Scozzafava

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 17:4866-4872

Sulthiame, a clinically used antiepileptic, was investigated for its interaction with 12 catalytically active mammalian carbonic anhydrase (CA, EC 4.2.1.1) isoforms. The drug is a potent inhibitor of CA II, VII, IX, and XII ( K I s of 6–56 nM), and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba1a441a4ad601b6ccdc98cc8f19d09
https://doi.org/10.1016/j.bmcl.2007.06.044

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Carbonic anhydrase activators: l-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV

Autor: Claudiu T. Supuran, Claudia Temperini, Andrea Scozzafava, Antonio Mastrolorenzo, Alessio Innocenti

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 17:628-635

The activation of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) with l -adrenaline and histamine has been investigated by kinetic and X-ray crystallographic studies. l -Adrenaline behaves as a potent activator of isozyme CA I (activation cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d383c2112302d9736bfc173cf6bbda8
https://doi.org/10.1016/j.bmcl.2006.11.027

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