Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Antonio Limatola"'
Autor:
Andres Binolfi, Antonio Limatola, Silvia Verzini, Jonas Kosten, Francois-Xavier Theillet, Honor May Rose, Beata Bekei, Marchel Stuiver, Marleen van Rossum, Philipp Selenko
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
α-synuclein is a protein linked to the occurrence of Parkinson's disease. Here, the authors use time-resolved in-cell NMR spectroscopy to study the repair of methionine-oxidized α-synuclein by endogenous cellular enzymes.
Externí odkaz:
https://doaj.org/article/7fb253fdcc4e4807873bdf93d8263baf
Autor:
Paolo Grieco, Alfonso Carotenuto, Luigia Auriemma, Antonio Limatola, Salvatore Di Maro, Francesco Merlino, Maria Luisa Mangoni, Vincenzo Luca, Antonio Di Grazia, Stefano Gatti, Pietro Campiglia, Isabel Gomez-Monterrey, Ettore Novellino, Anna Catania
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61614 (2013)
Previous investigations indicate that α-melanocyte-stimulating hormone (α-MSH) and certain synthetic analogues of it exert antimicrobial effects against bacteria and yeasts. However, these molecules have weak activity in standard microbiology condi
Externí odkaz:
https://doaj.org/article/c9559ba0ca774c489a775f9114627d36
Autor:
Stefano Tomassi, Salvatore Di Maro, Claudio Luchinat, Stefano Giuntini, Ettore Novellino, Alfonso Carotenuto, Pasquale Russomanno, Marco Fragai, Linda Cerofolini, Antonio Limatola, Diego Brancaccio, Francesco Merlino
Publikováno v:
ACS Med Chem Lett
[Image: see text] Protein–protein interactions (PPIs) contribute to the onset and/or progression of several diseases, especially cancer, and this discovery has paved the way for considering disruption of the PPIs as an attractive anti-tumor strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a3e5e690c45e4b4aba0b7bccdfbb17
https://europepmc.org/articles/PMC7236535/
https://europepmc.org/articles/PMC7236535/
The eukaryotic chaperonin TRiC/CCT is a large hetero-oligomeric complex that plays an essential role assisting cellular protein folding and suppressing protein aggregation. It consists of two rings, and each composed of eight different subunits; non-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53cc59eeaa5014ecc11532a71808140
https://europepmc.org/articles/PMC6776438/
https://europepmc.org/articles/PMC6776438/
Autor:
Cédric Eichmann, Reeba Susan Jacob, Philipp Selenko, Andres Binolfi, Michal Sharon, Gili Ben-Nissan, Antonio Limatola
Publikováno v:
Proteomics
Targeted proteolysis of the disordered Parkinson's disease protein alpha-synuclein (αSyn) constitutes an important event under physiological and pathological cell conditions. In this work, site-specific αSyn cleavage by different endopeptidases in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4433e3dc493130501717b0149187e91a
https://pubmed.ncbi.nlm.nih.gov/30260559
https://pubmed.ncbi.nlm.nih.gov/30260559
Autor:
Minying Cai, Diego Brancaccio, Yang Zhou, Antonio Limatola, Ali Munaim Yousif, Victor J. Hruby, Paolo Grieco, Salvatore Di Maro, Silvia Zappavigna, Alfonso Carotenuto, Francesco Merlino, Ettore Novellino
We report the development of macrocyclic melanocortin derivatives of MT-II and SHU-9119, achieved by modifying the cycle dimension and incorporating constrained amino acids in ring-closing. This study culminated in the discovery of novel agonists/ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ae60c0b7b443d05f0cb64b6b4b5a97
http://hdl.handle.net/11591/393422
http://hdl.handle.net/11591/393422
Autor:
Antonio Limatola, Frank Porreca, Azzurra Stefanucci, Alfonso Carotenuto, Reza Samavati, Ferenc Zádor, Sándor Benyhe, Ettore Novellino, Adriano Mollica, Roberto Costante, Victor J. Hruby, Peg Davis, Francesco Pinnen, Stefano Pieretti, Anna Borsodi
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1032-1036
Two novel opioid analogues have been designed by substituting the native d-Ala residues in position 2,2' of biphalin with two residues of d-penicillamine or l-penicillamine and by forming a disulfide bond between the thiol groups. The so-obtained com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9ab15d472ff81d7687276c7b09d490
https://doi.org/10.1021/ml500241n
https://doi.org/10.1021/ml500241n
Autor:
Ermelinda Vernieri, Isabel Gomez-Monterrey, Ettore Novellino, Paolo Grieco, Alessia Bertamino, Maria Soprano, Alfonso Carotenuto, Veronica Di Sarno, Antonio Limatola, Marina Sala, Pietro Campiglia, Maddalena Illario, Sandro Cosconati, Simona Musella, Maria Rosaria Rusciano
Publikováno v:
Journal of Medicinal Chemistry. 56:5407-5421
Analogues of the previously described spiro[imidazo[1,5-c]thiazole-3, 3′-indoline]-2′,5,7(6H,7aH)-trione p53 modulators were prepared to explore new structural requirements at the thiazolidine domain for the antiproliferative activity and p53 mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b805f61b403c4680a17036ca866f6c75
https://doi.org/10.1021/jm400311n
https://doi.org/10.1021/jm400311n
Autor:
Stefania Meini, Luigia Auriemma, Ettore Novellino, Diego Brancaccio, Pietro Campiglia, Carlo Alberto Maggi, Alfonso Carotenuto, Antonio Limatola, Isabel Gomez-Monterrey, Roberta d'Emmanuele di Villa Bianca, Francesco Merlino, Paolo Santicioli, Paolo Grieco
Publikováno v:
Journal of Peptide Science. 19:293-300
Urotensin II (U-II) is a disulfide bridged peptide hormone identified as the ligand of a G-protein-coupled receptor. Human U-II (H-Glu-Thr-Pro-Asp-c[Cys-Phe-Trp-Lys-Tyr-Cys]-Val-OH) has been described as the most potent vasoconstrictor compound ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ed5a1e9090ff86489bc2236bc33d535
https://doi.org/10.1002/psc.2498
https://doi.org/10.1002/psc.2498
Autor:
Sabrina Taliani, Claudia Martini, Alfonso Carotenuto, Anna Lamberti, Valeria La Pietra, Leonardo Rossi, Luciana Marinelli, Antonio Limatola, Chiara Giacomelli, Maria Letizia Trincavelli, Ettore Novellino, Elisabetta Barresi, Federico Da Settimo, Barbara Costa, Simona Daniele, Eleonora Da Pozzo
Publikováno v:
Scientific Reports
In the complex scenario of cancer, treatment with compounds targeting multiple cell pathways has been emerging. In Glioblastoma Multiforme (GBM), p53 and Translocator Protein (TSPO), both acting as apoptosis inducers, represent two attractive intrace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7452d5571a80ad119cbb8245a80bc61d
http://hdl.handle.net/11588/585756
http://hdl.handle.net/11588/585756