Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Antonio Layoun"'
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Iron homeostasis is tightly regulated to provide virtually all cells in the body, particularly red blood cells, with this essential element while defending against its toxicity. The peptide hormone hepcidin is central to the control of the amount of
Externí odkaz:
https://doaj.org/article/4c4405d3afca44ecbe3ef9a29f05e875
Autor:
Kristoff Nelson, Jeffrey Downey, Maziar Divangahi, Antonio Layoun, Ortal Attias, Kwang-Bo Joung, T. Martin Schmeing, Philippe P. Roux, Alexander A. Goldberg, Jill A. Fielhaber, Ayesha Baig, Alexandra Carella, Nahomi Amberber, Arnold S. Kristof, Mikaela Eng, Yingshan Han
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
Inactivation of the protein complex ‘mechanistic target of rapamycin complex 1’ (mTORC1) can increase the nuclear content of transcriptional regulators of metabolism and apoptosis. Previous studies established that nuclear import of signal transd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccfcc1e521b153b1309325fe657c37ac
http://link.springer.com/article/10.1038/s41598-019-53909-5
http://link.springer.com/article/10.1038/s41598-019-53909-5
Autor:
Maziar Divangahi, Kwang-Bo Joung, Ortal Attias, T. Martin Schmeing, Alexander A. Goldberg, Alexandra Carella, Jeffrey Downey, Antonio Layoun, Ayesha Baig, Philippe P. Roux, Mikaela Eng, Jill A. Fielhaber, Yingshan Han, Nahomi Amberber, Kristoff Nelson, Arnold S. Kristof
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
Inactivation of the protein complex 'mechanistic target of rapamycin complex 1' (mTORC1) can increase the nuclear content of transcriptional regulators of metabolism and apoptosis. Previous studies established that nuclear import of signal transducer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d4a61bfdae23299d2c2afd47dc7933
https://doi.org/10.1038/s41598-020-58962-z
https://doi.org/10.1038/s41598-020-58962-z
Publikováno v:
BioMetals. 26:1051-1065
Hepcidin is an antimicrobial peptide hormone that plays a central role in the metabolism of iron and its expression in the liver can be induced through two major pathways: the inflammatory pathway, mainly via IL-6; and the iron-sensing pathway, media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1286bb19e466878f833e6c31962f8493
https://doi.org/10.1007/s10534-013-9683-6
https://doi.org/10.1007/s10534-013-9683-6
Publikováno v:
The American Journal of Pathology. 180:2340-2350
Hypoferremia, associated with immune system activation, involves a marked reduction in the levels of circulating iron, coupled with iron sequestration within macrophages. Toll-like receptor (TLR) signaling plays an important role in the development o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aed7dd36bc1fc0c8d69105458cd9c94
https://doi.org/10.1016/j.ajpath.2012.01.046
https://doi.org/10.1016/j.ajpath.2012.01.046
Autor:
Antonio Layoun, Manuela M. Santos
Publikováno v:
Inflammation. 35:1500-1506
Hepcidin is a key regulator of iron recycling by macrophages that is synthesized mainly by hepatocytes but also by macrophages. However, very little is known about the molecular regulation of hepcidin in macrophages. In the present study, we investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e37c1e4bcc9c79b61e1409f4a11356
https://doi.org/10.1007/s10753-012-9463-4
https://doi.org/10.1007/s10753-012-9463-4
Publikováno v:
Journal of Visualized Experiments.
During infection and inflammation, circulating monocytes leave the bloodstream and migrate into tissues, where they differentiate into macrophages. Macrophages express surface Toll-like receptors (TLRs), which recognize molecular patterns conserved t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f76c747a2bfec7d1f9810e548f0a35
https://doi.org/10.3791/52749-v
https://doi.org/10.3791/52749-v
Hepcidin, a key regulator of iron metabolism, is a small antimicrobial peptide produced by the liver that regulates intestinal iron absorption and iron recycling by macrophages. Hepcidin is stimulated when iron stores increase and during inflammation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a099a0ff6fdd61ab6d4eb2a04d23b5
https://europepmc.org/articles/PMC2891008/
https://europepmc.org/articles/PMC2891008/
