MyD88 Adaptor Protein Is Required for Appropriate Hepcidin Induction in Response to Dietary Iron Overload in Mice

Autor: Antonio Layoun, Macha Samba-Mondonga, Gabriela Fragoso, Annie Calvé, Manuela M. Santos

Publikováno v: Frontiers in Physiology, Vol 9 (2018)

Iron homeostasis is tightly regulated to provide virtually all cells in the body, particularly red blood cells, with this essential element while defending against its toxicity. The peptide hormone hepcidin is central to the control of the amount of

Externí odkaz: https://doaj.org/article/4c4405d3afca44ecbe3ef9a29f05e875

Publisher Correction: Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1

Autor: Maziar Divangahi, Kwang-Bo Joung, Ortal Attias, T. Martin Schmeing, Alexander A. Goldberg, Alexandra Carella, Jeffrey Downey, Antonio Layoun, Ayesha Baig, Philippe P. Roux, Mikaela Eng, Jill A. Fielhaber, Yingshan Han, Nahomi Amberber, Kristoff Nelson, Arnold S. Kristof

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)

Inactivation of the protein complex 'mechanistic target of rapamycin complex 1' (mTORC1) can increase the nuclear content of transcriptional regulators of metabolism and apoptosis. Previous studies established that nuclear import of signal transducer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d4a61bfdae23299d2c2afd47dc7933
https://doi.org/10.1038/s41598-020-58962-z

Toll-Like Receptor Signal Adaptor Protein MyD88 Is Required for Sustained Endotoxin-Induced Acute Hypoferremic Response in Mice

Autor: Annie Calvé, Antonio Layoun, Hua Huang, Manuela M. Santos

Publikováno v: The American Journal of Pathology. 180:2340-2350

Hypoferremia, associated with immune system activation, involves a marked reduction in the levels of circulating iron, coupled with iron sequestration within macrophages. Toll-like receptor (TLR) signaling plays an important role in the development o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aed7dd36bc1fc0c8d69105458cd9c94
https://doi.org/10.1016/j.ajpath.2012.01.046

Isolation of Murine Peritoneal Macrophages to Carry Out Gene Expression Analysis Upon Toll-like Receptors Stimulation

Autor: Antonio Layoun, Manuela M. Santos, Macha Samba

Publikováno v: Journal of Visualized Experiments.

During infection and inflammation, circulating monocytes leave the bloodstream and migrate into tissues, where they differentiate into macrophages. Macrophages express surface Toll-like receptors (TLRs), which recognize molecular patterns conserved t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f76c747a2bfec7d1f9810e548f0a35
https://doi.org/10.3791/52749-v

Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1.

Autor: Layoun, Antonio¹ (AUTHOR), Goldberg, Alexander A.¹ (AUTHOR), Baig, Ayesha¹ (AUTHOR), Eng, Mikaela¹ (AUTHOR), Attias, Ortal¹ (AUTHOR), Nelson, Kristoff¹ (AUTHOR), Carella, Alexandra¹ (AUTHOR), Amberber, Nahomi¹ (AUTHOR), Fielhaber, Jill A.¹ (AUTHOR), Joung, Kwang-Bo¹ (AUTHOR), Schmeing, T. Martin² (AUTHOR), Han, Yingshan¹ (AUTHOR), Downey, Jeffrey³ (AUTHOR), Divangahi, Maziar³ (AUTHOR), Roux, Philippe P.⁴ (AUTHOR), Kristof, Arnold S.¹ (AUTHOR) arnold.kristof@mcgill.ca

Publikováno v: Scientific Reports. Dec2019, Vol. 9 Issue 1, p1-8. 8p.