Výsledky vyhledávání - "Antonio J. da Silva"

Exchanging human Fcγ1 with murine Fcγ2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung metastasis model

Autor: Bernd Schlereth, Sandrine Crommer, Antonio J. da Silva, Robert Hofmeister, Grit Lorenczewski, Mathias Locher, Laetitia Petersen, Klaus Brischwein, Patrick A. Baeuerle, Sandra Lippold, Petra Lutterbuese

Publikováno v: Cancer Immunology, Immunotherapy. 56:459-468

An important mode of action shared by human IgG1 antibody therapies is antibody-dependent cellular cytotoxicity (ADCC). ADCC relies on the interaction of the antibody's Fc portion with Fc-gama receptors (FcgammaR) on immune effector cells. The anti-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c78037f9259ddec90571c9bba45c2f
https://doi.org/10.1007/s00262-006-0218-7

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MT110: A novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors

Autor: Bernd Schlereth, Mathias Locher, Pauline Wimberger, Benjamin Guller, Thomas Urbig, Sonja Offner, Ralf Lutterbuese, Robert Hofmeister, Andreas Wolf, Iduna Fichtner, Antonio J. da Silva, Rainer Kimmig, Tobias Raum, Peter Kufer, Klaus Brischwein, Carola Steiger, Petra Kleindienst, Patrick A. Baeuerle

Publikováno v: Molecular Immunology. 43:1129-1143

We have developed a novel single-chain Ep-CAM-/CD3-bispecific single-chain antibody construct designated MT110. MT110 redirected unstimulated human peripheral T cells to induce the specific lysis of every Ep-CAM-expressing tumor cell line tested. MT1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d079643e094e9acea1fe2996e2093e
https://doi.org/10.1016/j.molimm.2005.07.034

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Potent inhibition of local and disseminated tumor growth in immunocompetent mouse models by a bispecific antibody construct specific for Murine CD3

Autor: Antonio J. da Silva, Petra Kleindienst, Roman Kischel, Sandra Lippold, Klaus Brischwein, Iduna Fichtner, Patrick A. Baeuerle, Bernd Schlereth, Mathias Locher, Ralf Lutterbüse, Grit Lorenczewski, Peter Kufer

Publikováno v: Cancer Immunology, Immunotherapy. 55:785-796

Bispecific single-chain antibody constructs specific for human CD3 have been extensively studied for antitumor activity in human xenograft models using severe combined immunodeficient mice supplemented with human T cells. High efficacy at low effecto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277bb1e20144892a1594bd75c1d227fe
https://doi.org/10.1007/s00262-005-0082-x

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Eradication of Tumors from a Human Colon Cancer Cell Line and from Ovarian Cancer Metastases in Immunodeficient Mice by a Single-Chain Ep-CAM-/CD3-Bispecific Antibody Construct

Autor: Klaus Brischwein, Bernd Schlereth, Rainer Kimmig, Grit Lorenczewski, Pauline Wimberger, Petra Kleindienst, Iduna Fichtner, Patrick A. Baeuerle, Ralf Lutterbuese, Ilse Junghahn, Peter Kufer, Antonio J. da Silva, Sabine Kasimir-Bauer

Publikováno v: Cancer Research. 65:2882-2889

Bispecific T-cell engager (BiTE) are a class of bispecific single-chain antibodies that can very effectively redirect cytotoxic T cells for killing of tumor target cells. Here, we have assessed the in vivo efficacy of one representative, called bscEp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12eeca3ca687c272de0b057f06d02251
https://doi.org/10.1158/0008-5472.can-04-2637

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Comparison of Gene Expression Patterns Induced by Treatment of Human Umbilical Vein Endothelial Cells with IFN-α2b vs. IFN-β1a: Understanding the Functional Relationship Between Distinct Type I Interferons That Act Through a Common Receptor

Autor: Adrian Whitty, Paula S. Hochman, Alexander V. Lukashin, John Peyman, Margot Brickelmaier, Gerard R. Majeau, Antonio J. da Silva

Publikováno v: Journal of Interferon & Cytokine Research. 22:173-188

We analyzed whether interferon-alpha 2b (IFN-alpha 2b) and IFN-beta 1a engage their common receptor to generate activated receptor complexes possessing distinct signaling properties. Human vascular endothelial cells (HUVEC) are 100-1000-fold more sen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f4382cce1ea8971ae62cb49d20662a
https://doi.org/10.1089/107999002753536149

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Akademický článek

An approach to robust condition monitoring in industrial processes using pythagorean membership grades

Autor: ADRIÁN RODRÍGUEZ RAMOS, JOSÉ M. BERNAL DE LÁZARO, CARLOS CRUZ CORONA, ANTÔNIO J. DA SILVA NETO, ORESTES LLANES-SANTIAGO

Publikováno v: Anais da Academia Brasileira de Ciências, Vol 94, Iss 4 (2022)

Abstract In this paper, a robust approach to improve the performance of a condition monitoring process in industrial plants by using Pythagorean membership grades is presented. The FCM algorithm is modified by using Pythagorean fuzzy sets, to obtain

Externí odkaz: https://doaj.org/article/abd9824890af4fb3b86412f551beec4f

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FYN-T-FYB-SLP-76 Interactions Define a T-cell Receptor ζ/CD3-mediated Tyrosine Phosphorylation Pathway That Up-regulates Interleukin 2 Transcription in T-cells

Autor: Antonio J. da Silva, Hyun Min Kang, Monika Raab, Christopher E. Rudd, Xiaochun Zhu

Publikováno v: Journal of Biological Chemistry. 274:21170-21179

Protein-tyrosine kinases p56(Lck), SYK, and ZAP-70 and downstream adaptors LAT and SLP-76 have been implicated as essential components in T-cell activation. Another lymphoid-specific adaptor FYB/SLAP has also been identified as a predominant binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad09f88a0081872e7930bbe141169520
https://doi.org/10.1074/jbc.274.30.21170

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Regulation of Vav–SLP-76 Binding by ZAP-70 and Its Relevance to TCRζ/CD3 Induction of Interleukin-2

Autor: Antonio J. da Silva, Paul R. Findell, Christopher E. Rudd, Monika Raab

Publikováno v: Immunity. 6(2):155-164

T cell activation stimulates p56(lck), p59(fyn), ZAP-70, Vav-SLP-76 binding, and IL-2 transcription. Major questions concern the tyrosine-kinase and relevant site(s) needed for Vav-SLP-76 complex formation and its role in IL-2 production. Here, we sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1aee9c77996e50edfae8c4839ee0ec

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The Fes Protein-Tyrosine Kinase Phosphorylates a Subset of Macrophage Proteins That Are Involved in Cell Adhesion and Cell-Cell Signaling

Autor: Manfred Jücker, Ricardo A. Feldman, Christopher E. Rudd, Kyle C. McKenna, Antonio J. da Silva

Publikováno v: Journal of Biological Chemistry. 272:2104-2109

The c-fps/fes proto-oncogene encodes a 92-kDa protein-tyrosine kinase that is expressed at high levels in macrophages. We have previously shown that overexpression of c-fps/fes in a CSF-1-dependent macrophage cell line (BAC1.2F5) partially released t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16737788c464869bd1915b5e249f8325
https://doi.org/10.1074/jbc.272.4.2104

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Two-step TCRζ/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases

Autor: Ottmar Janssen, Antonio J. da Silva, K. V S Prasad, Yun Cai Cai, Monika Raab, Christopher E. Rudd

Publikováno v: Immunology Today. 15:225-234

A central question in T-cell immunity concerns the nature of intracellular signaling from the antigen receptor, the CD4/CD8 co-receptors and the CD28 antigen. Since the original discovery that T-cell receptors such as CD4 can interact with intracellu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f55b6a295fb8dea19671b8c3ae549e4
https://doi.org/10.1016/0167-5699(94)90248-8

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