Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Antonio García-España"'
Autor:
Marián Merino, Sonia González, Mª Carmen Tronch, Ana Virginia Sánchez-Sánchez, Mª Paz Clares, Antonio García-España, Enrique García-España, José L. Mullor
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15153 (2023)
Huntington’s disease (HD) is an inherited neurodegenerative disorder considered a rare disease with a prevalence of 5.7 per 100,000 people. It is caused by an autosomal dominant mutation consisting of expansions of trinucleotide repeats that transl
Externí odkaz:
https://doaj.org/article/ab5b964ebfd64f46b1e51f31c9b59531
Autor:
Javier U. Chicote, Marcos López-Sánchez, Tomàs Marquès-Bonet, José Callizo, Luis A. Pérez-Jurado, Antonio García-España
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-11 (2020)
Abstract Background Duplications of large genomic segments provide genetic diversity in genome evolution. Despite their importance, how these duplications are generated remains uncertain, particularly for distant duplicated genomic segments. Results
Externí odkaz:
https://doaj.org/article/1afd508c09bd4519b7edf24604ff736a
Autor:
Mario Inclán, María Teresa Albelda, Salvador Blasco, Carolina Serena, Javier Ugarte Chicote, Antonio García-España, Enrique García-España
Publikováno v:
Applied Sciences, Vol 12, Iss 5, p 2447 (2022)
Living organisms depend on superoxide dismutase (SOD) enzymes to shield themselves from the deleterious effects of superoxide radical. In humans, alterations of these protective mechanisms have been linked to the pathogenesis of many diseases. Howeve
Externí odkaz:
https://doaj.org/article/8b228089dd5c4b4b9610c56da3bfdd8b
Autor:
Ana Virginia Sánchez-Sánchez, Antonio García-España, Pilar Sánchez-Gómez, Jaime Font-de-Mora, Marián Merino, José Luis Mullor
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10620 (2021)
NANOG is a key transcription factor required for maintaining pluripotency of embryonic stem cells. Elevated NANOG expression levels have been reported in many types of human cancers, including lung, oral, prostate, stomach, breast, and brain. Several
Externí odkaz:
https://doaj.org/article/3db15eb75f3f4b908052e2e3eac1cd59
Autor:
Lluís Guijarro, Álvaro Martínez-Camarena, Javier U. Chicote, Antonio García-España, Enrique García-España, Mario Inclán, Begoña Verdejo, Jorge González-García
Publikováno v:
Molecules, Vol 26, Iss 13, p 3957 (2021)
Nucleic acids are essential biomolecules in living systems and represent one of the main targets of chemists, biophysics, biologists, and nanotechnologists. New small molecules are continuously developed to target the duplex (ds) structure of DNA and
Externí odkaz:
https://doaj.org/article/c95ec5d646594770b5c210c3f4031da8
Autor:
Daniela Parra, Manuela Sáenz-Valcárcel, Laura Claverias, Sandra Trefler, María Bodí, Judith Marín-Corral, Antonio García-España, Alejandro Rodriguez, Luis Felipe Reyes
Publikováno v:
Journal of Clinical and Translational Science, Vol 4, Pp 139-139 (2020)
OBJECTIVES/GOALS: To determine the relationship among serum concentration of tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) and mortality in community-acquired pneumonia (CAP) patients. METHODS/STUDY POPULATION: This is a multicen
Externí odkaz:
https://doaj.org/article/ccd8700aafa840c1bb0e4053ba272643
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172887 (2017)
Subtype R3 phosphotyrosine phosphatase receptors (R3 RPTPs) are single-spanning membrane proteins characterized by a unique modular composition of extracellular fibronectin repeats and a single cytoplasmatic protein tyrosine phosphatase (PTP) domain.
Externí odkaz:
https://doaj.org/article/65263968967d40e78d7402e1f5060c82
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170196 (2017)
Uroplakins are a widespread group of vertebrate integral membrane proteins that belong to two different families: UPK1a and UPK1b belong to the large tetraspanin (TSPAN) gene family, and UPK3a, UPK3b, UPK3c, UPK3d, UPK2a and UPK2b form a family of th
Externí odkaz:
https://doaj.org/article/072331b1a1174f06ba15085d1a7f1575
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172416 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0170196.].
Externí odkaz:
https://doaj.org/article/eabb7c07c18f49a6b225dfe58f2e5ae4
Autor:
Carolina Serena, Enrique Calvo, Mari Paz Clares, María Luisa Diaz, Javier U Chicote, Raúl Beltrán-Debon, Ramón Fontova, Alejandro Rodriguez, Enrique García-España, Antonio García-España
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119102 (2015)
The clinical use of purified SOD enzymes has strong limitations due to their large molecular size, high production cost and immunogenicity. These limitations could be compensated by using instead synthetic SOD mimetic compounds of low molecular weigh
Externí odkaz:
https://doaj.org/article/18bd9eb90f4a4a50aa1e07480803b7ac