Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Antonio García‐Merino"'
Autor:
Alicia Sánchez-Sanz, María Posada-Ayala, Julia Sabín-Muñoz, Ismael Fernández-Miranda, Yolanda Aladro-Benito, Roberto Álvarez-Lafuente, Ana Royuela, Ruth García-Hernández, Ofir Rodríguez-De la Fuente, Julián Romero, Antonio García-Merino, Antonio José Sánchez-López
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The endocannabinoid system (ECS), a signalling network with immunomodulatory properties, is a potential therapeutic target in multiple sclerosis (MS). Dimethyl fumarate (DMF) is an approved drug for MS whose mechanism of action has not been
Externí odkaz:
https://doaj.org/article/dc14a0194f1344d1a8ef18b5b2fed8c6
Autor:
Alicia Sánchez-Sanz, Santiago García-Martín, Julia Sabín-Muñoz, Irene Moreno-Torres, Víctor Elvira, Fátima Al-Shahrour, Aranzazu García-Grande, Elvira Ramil, Ofir Rodríguez-De la Fuente, Beatriz Brea-Álvarez, Ruth García-Hernández, Antonio García-Merino, Antonio José Sánchez-López
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Background and objectiveDimethyl fumarate (DMF) is an immunomodulatory drug approved for the therapy of multiple sclerosis (MS). The identification of response biomarkers to DMF is a necessity in the clinical practice. With this aim, we studied the i
Externí odkaz:
https://doaj.org/article/1e48099cbabe47af932b66bcc498ce5e
Autor:
José E. Meca-Lallana, Bonaventura Casanova, Alfredo Rodríguez-Antigüedad, Sara Eichau, Guillermo Izquierdo, Carmen Durán, Jordi Río, Miguel Ángel Hernández, Carmen Calles, José M. Prieto-González, José Ramón Ara, Dionisio F. Uría, Lucienne Costa-Frossard, Antonio García-Merino, Celia Oreja-Guevara
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
BackgroundEarly identification of the transition from relapsing-remitting multiple sclerosis (RRMS) to secondary progressive MS (SPMS) can be challenging for clinicians, as diagnostic criteria for SPMS are primarily based on physical disability and a
Externí odkaz:
https://doaj.org/article/aa9c9b31ac3d4967b3581b1660d1bab5
Autor:
Francisco Carlos Pérez‐Miralles, Daniel Prefasi, Antonio García‐Merino, José Ramón Ara, Guillermo Izquierdo, Virginia Meca‐Lallana, Francisco Gascón‐Giménez, María Luisa Martínez‐Ginés, Lluis Ramió‐Torrentà, Lucienne Costa‐Frossard, Óscar Fernández, Sara Moreno‐García, Jorge Maurino, Joan Carreres‐Polo, Bonaventura Casanova
Publikováno v:
Brain and Behavior, Vol 11, Iss 4, Pp n/a-n/a (2021)
Abstract Background and purpose Evidence on regional changes resulting from neurodegenerative processes underlying primary progressive multiple sclerosis (PPMS) is still limited. We assessed brain region volumes and their relationship with disability
Externí odkaz:
https://doaj.org/article/1c68c742d928479ab6b1cd9c261aafe7
Autor:
Antonio García-Merino
Publikováno v:
Cells, Vol 10, Iss 10, p 2560 (2021)
B cells play a central role in the pathogenesis of multiple sclerosis (MS), as demonstrated through the success of various B cell-depleting monoclonal antibodies. Bruton’s tyrosine kinase (BTK) is a critical molecule in intracellular signaling from
Externí odkaz:
https://doaj.org/article/c4236b5b341d43acbd4fc59d4d20b950
Autor:
Irene Moreno-Torres, Coral González-García, Marco Marconi, Aranzazu García-Grande, Luis Rodríguez-Esparragoza, Víctor Elvira, Elvira Ramil, Lucía Campos-Ruíz, Ruth García-Hernández, Fátima Al-Shahrour, Coral Fustero-Torre, Alicia Sánchez-Sanz, Antonio García-Merino, Antonio José Sánchez López
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
BackgroundFingolimod is a functional sphingosine-1-phosphate antagonist approved for the treatment of multiple sclerosis (MS). Fingolimod affects lymphocyte subpopulations and regulates gene expression in the lymphocyte transcriptome. Translational s
Externí odkaz:
https://doaj.org/article/0eb7effe7da4496298ca48ff62744605
Autor:
Miguel A Ortiz, Concepción Núñez, David Ordóñez, José C Alvarez-Cermeño, José E Martínez-Rodriguez, Antonio J Sánchez, Rafael Arroyo, Guillermo Izquierdo, Sunny Malhotra, Xavier Montalban, Antonio García-Merino, Elvira Munteis, Antonio Alcina, Manuel Comabella, Fuencisla Matesanz, Luisa M Villar, Elena Urcelay
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134414 (2015)
Multiple sclerosis (MS) is a neurodegenerative, autoimmune disease of the central nervous system. Genome-wide association studies (GWAS) have identified over hundred polymorphisms with modest individual effects in MS susceptibility and they have conf
Externí odkaz:
https://doaj.org/article/71212e472792411cbda73856ca44fc86
Autor:
Ana Cabranes, Katerina Venderova, Eva de Lago, Filomena Fezza, Antonio Sánchez, Leyre Mestre, Marta Valenti, Antonio García-Merino, José Antonio Ramos, Vincenzo Di Marzo, Javier Fernández-Ruiz
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 2, Pp 207-217 (2005)
Recent studies have addressed the changes in endocannabinoid ligands and receptors that occur in multiple sclerosis, as a way to explain the efficacy of cannabinoid compounds to alleviate spasticity, pain, tremor, and other signs of this autoimmune d
Externí odkaz:
https://doaj.org/article/83b9ccb2caa94a9fa93e9c9bdaaa5f06
Autor:
Barmavatu, Praveen, Anant Deshmukh, Sonali, Kumar Das, Mihir, Arabkoohsar, Ahmad, Antonio García-Merino, José, Rosales-Vera, Marco, Sunil Dsilva, Rolvin, Ramalinga Viswanathan, Mangalaraja, Gaddala, Baburao, Singh Sikarwar, Vineet
Publikováno v:
In Thermal Science and Engineering Progress October 2024 55
Autor:
Elia Gil-Varea, Elena Urcelay, Carles Vilariño-Güell, Carme Costa, Luciana Midaglia, Fuencisla Matesanz, Alfredo Rodríguez-Antigüedad, Jorge Oksenberg, Laura Espino-Paisan, A. Dessa Sadovnick, Albert Saiz, Luisa M. Villar, Juan Antonio García-Merino, Lluís Ramió-Torrentà, Juan Carlos Triviño, Ester Quintana, René Robles, Antonio Sánchez-López, Rafael Arroyo, Jose C. Alvarez-Cermeño, Angela Vidal-Jordana, Sunny Malhotra, Nicolas Fissolo, Xavier Montalban, Manuel Comabella
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-10 (2018)
Abstract Background It remains unclear whether disease course in multiple sclerosis (MS) is influenced by genetic polymorphisms. Here, we aimed to identify genetic variants associated with benign and aggressive disease courses in MS patients. Methods
Externí odkaz:
https://doaj.org/article/833c0146c0374957a77d4180572e95c7