OSMAC Approach and Cocultivation for the Induction of Secondary Metabolism of the Fungus Pleotrichocladium opacum

Autor: Víctor Rodríguez Martín-Aragón, Mónica Trigal Martínez, Cristina Cuadrado, Antonio Hernández Daranas, Antonio Fernández Medarde, José M. Sánchez López

Publikováno v: ACS Omega, Vol 8, Iss 42, Pp 39873-39885 (2023)

Externí odkaz: https://doaj.org/article/ae4dbf88a60f4fc5beafe3a5367cd817

The Marine Fungal Metabolite, AD0157, Inhibits Angiogenesis by Targeting the Akt Signaling Pathway

Autor: Melissa García-Caballero, Librada Cañedo, Antonio Fernández-Medarde, Miguel Ángel Medina, Ana R. Quesada

Publikováno v: Marine Drugs, Vol 12, Iss 1, Pp 279-299 (2014)

In the course of a screening program for the inhibitors of angiogenesis from marine sources, AD0157, a pyrrolidinedione fungal metabolite, was selected for its angiosupressive properties. AD0157 inhibited the growth of endothelial and tumor cells in

Externí odkaz: https://doaj.org/article/e5693be9634c4b1bbbb62048ea36682d

Identification of synergists that potentiate the action of polymyxin B against Burkholderia cenocepacia

Autor: José María Sánchez López, Julian Davies, Omar M. El-Halfawy, Antonio Fernández Medarde, Agatha N. Jassem, David P. Speert, Miguel A. Valvano, Slade A. Loutet

Publikováno v: Loutet, S A, El-Halfawy, O M, Jassem, A N, Sánchez López, J M, Fernández Medarde, A, Speert, D P, Davies, J E & Valvano, M A 2015, ' Identification of synergists that potentiate the action of polymyxin B against Burkholderia cenocepacia ', International Journal of Antimicrobial Agents, vol. 46, no. 4, pp. 376-380 . https://doi.org/10.1016/j.ijantimicag.2015.05.010

Burkholderia cenocepacia and other members of the Burkholderia cepacia complex (Bcc) are highly multidrug-resistant bacteria that cause severe pulmonary infections in patients with cystic fibrosis. A screen of 2686 compounds derived from marine organ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd161747b04edce89d926d47dcb659f8
https://doi.org/10.1016/j.ijantimicag.2015.05.010

Antiangiogenic versus cytotoxic activity in analogues of aeroplysinin-1

Autor: Antonio Fernández Medarde, Joaquín Plumet, Nélida Salvador Tormo, Rubén Córdoba

Publikováno v: Bioorganicmedicinal chemistry. 15(15)

A series of analogues of the potentially angiogenic inhibitor aeroplysinin-1 1 were synthesized and their in vitro antiangiogenic and cytotoxic activities evaluated. In the case of epoxy ketone 6 and azlactone 36 the relationship sprouting inhibition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2390a3907eb0bff3f68e5ad45851c93c
https://pubmed.ncbi.nlm.nih.gov/17507232