Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Antonio E. Lacerda"'
Autor:
Amal Ting, Abby Sewell, Cecilia Pena-Rasgado, Dominic Picarella, Antonio E. Lacerda, Maisy Yeager, Chi B. Vu, Chandran Sachin, Pallavi Lonkar, Robert J. Bridges, A. Nichols, Curtis Bordwell, Feng Liu, Allison Wensley
Publikováno v:
Journal of medicinal chemistry. 60(1)
A depressed autophagy has previously been reported in cystic fibrosis patients with the common F508del-CFTR mutation. This report describes the synthesis and preliminary biological characterization of a novel series of autophagy activators involving
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607c956539a95bf8ee1044f49ccb95b8
https://pubmed.ncbi.nlm.nih.gov/27976892
https://pubmed.ncbi.nlm.nih.gov/27976892
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 61:277-286
Introduction The cardiac action potential (CAP) of stem cell-derived human cardiomyocytes (SC-hCMs) is potentially the most powerful preclinical biomarker for cardiac safety and efficacy in humans. Our experiments tested this hypothesis by examining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11d6628b961706e4575ed9e616a185f
https://doi.org/10.1016/j.vascn.2010.01.014
https://doi.org/10.1016/j.vascn.2010.01.014
Publikováno v:
Journal of Cardiovascular Electrophysiology. 21:301-310
There remains an unmet need for safe and effective antiarrhythmic drugs, especially for the treatment of atrial fibrillation. Vanoxerine is a drug that is free of adverse cardiac events in normal volunteers, yet is a potent blocker of the hERG (hK(v)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8adba25b371dca34dd3ed39dd62772
https://doi.org/10.1111/j.1540-8167.2009.01623.x
https://doi.org/10.1111/j.1540-8167.2009.01623.x
Autor:
Andrew Bruening-Wright, Arthur Brown, Carlos A. Obejero-Paz, James Kramer, Antonio E. Lacerda
Publikováno v:
Biophysical Journal. 108(2)
GBR-12909 (vanoxerine) is a potent highly selective dopamine transporter antagonist. It was initially developed for treatment of Parkinson's disease and while safe in man, lacked efficacy. Although a potent hERG blocker, the drug exhibits multiple io
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdefc970bd23d90b5ef9dc721752144f
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 277:H199-H210
The rapid, repolarizing K+ current in cardiomyocytes ( I Kr) has unique inwardly rectifying properties that contribute importantly to the downstroke of the cardiac action potential. The human ether-à-go-go-related gene ( HERG) expresses a macroscopi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7f427405e971e7f4cb4722567a3123
https://doi.org/10.1152/ajpheart.1999.277.1.h199
https://doi.org/10.1152/ajpheart.1999.277.1.h199
Autor:
Toni Schneider, Edward Perez-Reyes, Jung-Ha Lee, Asif N. Daud, Antonio E. Lacerda, Leanne L. Cribbs, Udo Klöckner, Alexei Pereverzev
Publikováno v:
The Journal of Neuroscience. 19:1912-1921
Low voltage-activated Ca2+channels play important roles in pacing neuronal firing and producing network oscillations, such as those that occur during sleep and epilepsy. Here we describe the cloning and expression of the third member of the T-type fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88000e17d9dc2f4c760ff75cc0207350
https://doi.org/10.1523/jneurosci.19-06-01912.1999
https://doi.org/10.1523/jneurosci.19-06-01912.1999
Autor:
Jane Barclay, Antonio E. Lacerda, Magali Williamson, Asif N. Daud, Edward Perez-Reyes, Leanne L. Cribbs, Margaret Fox, M Rees, Jung-Ha Lee
Publikováno v:
Nature. 391:896-900
The molecular diversity of voltage-activated calcium channels was established by studies showing that channels could be distinguished by their voltage-dependence, deactivation and single-channel conductance. Low-voltage-activated channels are called
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018c9a622a0e485938e0c09dd18cd011
https://doi.org/10.1038/36110
https://doi.org/10.1038/36110
Publikováno v:
Biophysical Journal. 66(6):1833-1843
We used amplifying effects of calcium channel beta subunits to identify endogenous calcium channels in Xenopus oocytes. Expression of rat brain beta 4 increased macroscopic endogenous current magnitude with a small effect on kinetics. In contrast, ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a112d354bf8963fcff8bd838d4dc4a89
Autor:
Alan Neely, Edward Perez-Reyes, Antonio E. Lacerda, Lutz Birnbaumer, Riccardo Olcese, Xiangyang Wei, Enrico Stefani
Publikováno v:
Journal of Biological Chemistry. 269:1635-1640
Voltage-sensitive Ca2+ channels are multisubunit complexes that include, among others, a large alpha 1 subunit, which by itself is sufficient to form a channel. Several alpha 1 genes encoding L-, N-, and P-type Ca2+ channels have been cloned. These a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a853bafaf9d064727946417e73c5e7
https://doi.org/10.1016/s0021-9258(17)42074-6
https://doi.org/10.1016/s0021-9258(17)42074-6
Autor:
Ivan Cakulev, Albert L. Waldo, Kyungmoo Ryu, Arthur Brown, M B S Celeen Khrestian, Antonio E. Lacerda
Vanoxerine is a promising, new, investigational antiarrhythmic drug. The purpose of this study was to test the hypothesis that oral dosing of vanoxerine would first terminate induced atrial flutter (AFL) and atrial fibrillation (AF), and then prevent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef15e851554616c71830964555a6351
https://europepmc.org/articles/PMC3172341/
https://europepmc.org/articles/PMC3172341/
