Efficacy and safety of intramuscular administration of allogeneic adipose tissue derived and expanded mesenchymal stromal cells in diabetic patients with critical limb ischemia with no possibility of revascularization: study protocol for a randomized controlled double-blind phase II clinical trial (The NOMA Trial)

Autor: Alejandro Gonzalez, Franz Martín, Antonio de la Cuesta Diaz, Fermín Sánchez-Guijo, César Aparicio, Manuel Miralles, Eva Villarón, Miriam Lopez Parra, María Eugenia Fernández-Santos, Barbara Soria-Juan, José Manuel Ligero, Abdelkrim Hmadcha, Bernat Soria, José M. Moraleda, Francisco S. Lozano, Mariano Garcia-Arranz, Rosa Yañez, Pedro J. Marín, Luis Hernandez-Blasco, Ignacio Mahillo Fernández, Ana M García-Hernández, Francisco J. Bedoya, Enrique J. Andreu, Lourdes Del Rio Sola, Juan R. Tejedo, Etelvina Andreu, Lukasz Grochowicz, Gregorio Castellanos, Lucía Llanos Jiménez, Luis Riera del Moral, Damian Garcia-Olmo, Francisco Morant

Publikováno v: Trials
Trials, Vol 22, Iss 1, Pp 1-12 (2021)
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe

Background Chronic lower limb ischemia develops earlier and more frequently in patients with type 2 diabetes mellitus. Diabetes remains the main cause of lower-extremity non-traumatic amputations. Current medical treatment, based on antiplatelet ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8d192b7c607777f41d03ff9a19dc05
https://doi.org/10.1186/s13063-021-05430-2

Angiographic demonstration of neoangiogenesis after intra-arterial infusion of autologous bone marrow mononuclear cells in diabetic patients with critical limb ischemia

Autor: Rafael Ruiz-Salmerón, Bernat Soria, Abdelkrim Hmadcha, Francisco Marcos-Sánchez, Antonio De La Cuesta-Diaz, Immaculada Pérez-Camacho, Manuel Constantino-Bermejo

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Cell Transplantation, Vol 20 (2011)

Licencia Creative Commons Reconocimiento-No comercial.
Critical limb ischemia in diabetic patients is associated with high rates of morbidity and mortality. Subopti-mal responses to the available medical and surgical treatments are common in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081faf92032bb08f493c16252746b7b7
https://pubmed.ncbi.nlm.nih.gov/22325054