Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Antonio Daniel Barbosa"'
Autor:
Michelle L Villasmil, Antonio Daniel Barbosa, Jessie Lee Cunningham, Symeon Siniossoglou, Joseph T Nickels
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235746 (2020)
Azole resistant fungal infections remain a health problem for the immune compromised. Current therapies are limited due to rises in new resistance mechanisms. Therefore, it is important to identify new drug targets for drug discovery and novel therap
Externí odkaz:
https://doaj.org/article/69957f3095894e4e9a1f75421cbf0efb
Publikováno v:
Communicative & Integrative Biology, Vol 9, Iss 4 (2016)
Survival during starvation depends largely on metabolic energy, which is stored in the form of neutral lipids in specialized organelles known as lipid droplets. The precursors for the synthesis of neutral lipids are also used for membrane biogenesis,
Externí odkaz:
https://doaj.org/article/77f3be8f7897412ba802335b03d81a7b
Publikováno v:
Current Opinion in Pharmacology
Autophagy is a lysosomal degradation pathway and the main clearance route of many toxic protein aggregates. The molecular pathology of Alzheimer's disease (AD) manifests in the form of protein aggregates—extracellular amyloid-β depositions and int
Publikováno v:
The FEBS Journal. 287:4838-4843
The regulation of lipid homeostasis is essential for normal cell physiology, and its disruption can lead to disease. Lipid droplets (LDs) are ubiquitous organelles dedicated to storing nonpolar lipids that are used for metabolic energy production or
Autor:
Philip A. Wigge, Antonio Daniel Barbosa, Mingjun Gao, Stephanie Hutin, Elodie Pierre, Feng Geng, Xuelei Lai, Dorothee Derwort, Catarina S. Silva, Sol-Bi Kim, Katja E. Jaeger, Sujeong Baek, Janet R. Kumita, Chloe Zubieta, Jaehoon Jung
Publikováno v:
Nature
Nature, 2020, 585 (7824), pp.256-260. ⟨10.1038/s41586-020-2644-7⟩
Nature, Nature Publishing Group, 2020, 585 (7824), pp.256-260. ⟨10.1038/s41586-020-2644-7⟩
Nature, 2020, 585 (7824), pp.256-260. ⟨10.1038/s41586-020-2644-7⟩
Nature, Nature Publishing Group, 2020, 585 (7824), pp.256-260. ⟨10.1038/s41586-020-2644-7⟩
International audience; Temperature controls plant growth and development, and climate change has already altered the phenology of wild plants and crops1. However, the mechanisms by which plants sense temperature are not well understood. The evening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf1a5e0af1d1cad76791514db668986
https://hal.science/hal-02954052/file/Jung_et_al_2020_draft.pdf
https://hal.science/hal-02954052/file/Jung_et_al_2020_draft.pdf
Autor:
Maya Schuldiner, James R. Edgar, Symeon Siniossoglou, Lihi Gal, Muriel Mari, Albert Koulman, Koini Lim, Antonio Daniel Barbosa, Peter Sterk, David B. Savage, Philip A. Wigge, Benjamin Jenkins, Fulvio Reggiori
Publikováno v:
Developmental Cell, 50(6), 755-766.e6. CELL PRESS
Barbosa, A D, Lim, K, Mari, M, Edgar, J R, Gal, L, Sterk, P, Jenkins, B J, Koulman, A, Savage, D B, Schuldiner, M, Reggiori, F, Wigge, P A & Siniossoglou, S 2019, ' Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization ', Developmental Cell, vol. 50, no. 6, pp. 755-766.e6 . https://doi.org/10.1016/j.devcel.2019.07.009
Developmental Cell
Barbosa, A D, Lim, K, Mari, M, Edgar, J R, Gal, L, Sterk, P, Jenkins, B J, Koulman, A, Savage, D B, Schuldiner, M, Reggiori, F, Wigge, P A & Siniossoglou, S 2019, ' Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization ', Developmental Cell, vol. 50, no. 6, pp. 755-766.e6 . https://doi.org/10.1016/j.devcel.2019.07.009
Developmental Cell
Summary Cells dynamically adjust organelle organization in response to growth and environmental cues. This requires regulation of synthesis of phospholipids, the building blocks of organelle membranes, or remodeling of their fatty-acyl (FA) compositi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2bcd76ccc1910091eeed2cc49e2003e
https://research.rug.nl/en/publications/e284ef4a-b7ff-4094-a6aa-bae36869a954
https://research.rug.nl/en/publications/e284ef4a-b7ff-4094-a6aa-bae36869a954
Autor:
Joseph T. Nickels, Antonio Daniel Barbosa, Symeon Siniossoglou, Michelle L. Villasmil, Jessie Lee Cunningham
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 7, p e0235746 (2020)
PLoS ONE, Vol 15, Iss 7, p e0235746 (2020)
Azole resistant fungal infections remain a health problem for the immune compromised. Current therapies are limited due to rises in new resistance mechanisms. Therefore, it is important to identify new drug targets for drug discovery and novel therap
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1864(9)
Storage of non-polar lipids in ubiquitous eukaryotic organelles, lipid droplets (LDs), prevents the toxic consequences of unesterified fatty acids and provides a lipid reservoir that can be promptly used to satisfy cellular needs under multiple metab
Sit4p is the catalytic subunit of a ceramide-activated PP2A-like phosphatase that regulates cell cycle, mitochondrial function, oxidative stress resistance and chronological lifespan in yeast. In this study, we show that hexokinase 2 (Hxk2p) is hyper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21fc161a8cae446041787b604b4cafed
https://europepmc.org/articles/PMC4934063/
https://europepmc.org/articles/PMC4934063/
Autor:
Susana Abreu, Hiroshi Sembongi, Wen-Min Su, Symeon Siniossoglou, George M. Carman, Antonio Daniel Barbosa, Fulvio Reggiori
Publikováno v:
Molecular Biology of the Cell, 26(20), 3641-3657. AMER SOC CELL BIOLOGY
Molecular Biology of the Cell
Barbosa, A D, Sembongi, H, Su, W-M, Abreu, S, Reggiori, F, Carman, G M & Siniossoglou, S 2015, ' Lipid partitioning at the nuclear envelope controls membrane biogenesis ', Molecular Biology of the Cell, vol. 26, no. 20, pp. 3641-57 . https://doi.org/10.1091/mbc.E15-03-0173
Molecular Biology of the Cell
Barbosa, A D, Sembongi, H, Su, W-M, Abreu, S, Reggiori, F, Carman, G M & Siniossoglou, S 2015, ' Lipid partitioning at the nuclear envelope controls membrane biogenesis ', Molecular Biology of the Cell, vol. 26, no. 20, pp. 3641-57 . https://doi.org/10.1091/mbc.E15-03-0173
Cells adjust the flux of lipid intermediates toward membranes or storage in response to their metabolic status. In response to growth cues, spatiotemporal activation of Pah1 at discrete subdomains of the nuclear envelope acts as a switch to promote l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433230f931e0a826f536df24946511e1
https://www.repository.cam.ac.uk/handle/1810/250555
https://www.repository.cam.ac.uk/handle/1810/250555