Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Antonio Cuevas-Navarro"'
Autor:
Antonio Cuevas-Navarro, Laura Rodriguez-Muñoz, Joaquim Grego-Bessa, Alice Cheng, Katherine A Rauen, Anatoly Urisman, Frank McCormick, Gerardo Jimenez, Pau Castel
Publikováno v:
eLife, Vol 11 (2022)
RAS GTPases are highly conserved proteins involved in the regulation of mitogenic signaling. We have previously described a novel Cullin 3 RING E3 ubiquitin ligase complex formed by the substrate adaptor protein LZTR1 that binds, ubiquitinates, and p
Externí odkaz:
https://doaj.org/article/186607128fba49338544764486aeac28
Autor:
Dongsung Kim, Lorenz Herdeis, Dorothea Rudolph, Yulei Zhao, Jark Böttcher, Alberto Vides, Carlos I. Ayala-Santos, Yasin Pourfarjam, Antonio Cuevas-Navarro, Jenny Y. Xue, Andreas Mantoulidis, Joachim Bröker, Tobias Wunberg, Otmar Schaaf, Johannes Popow, Bernhard Wolkerstorfer, Katrin Gabriele Kropatsch, Rui Qu, Elisa de Stanchina, Ben Sang, Chuanchuan Li, Darryl B. McConnell, Norbert Kraut, Piro Lito
Publikováno v:
Nature.
KRAS is one of the most commonly mutated proteins in cancer, and efforts to directly inhibit its function have been continuing for decades. The most successful of these has been the development of covalent allele-specific inhibitors that trap KRAS G1
Autor:
Omar Abdel-Wahab, Pau Castel, R. Coleman Lindsley, Frank McCormick, Neal Rosen, Justin Taylor, Sebastien Monette, Daichi Inoue, Michael F. Walsh, Elise Fiala, Tatiana S. Pavletich, Benjamin H. Durham, Steven Tittley, Dan Cui, Michael Singer, Caroline Erickson, Hana Cho, Robert F. Stanley, Won Jun Kim, Katherine Knorr, Salima Benbarche, Eric Wang, Simon J. Hogg, Bin Lu, Antonio Cuevas-Navarro, Rahul S. Vedula, Sisi Chen
Recently, screens for mediators of resistance to FLT3 and ABL kinase inhibitors in leukemia resulted in the discovery of LZTR1 as an adapter of a Cullin-3 RING E3 ubiquitin ligase complex responsible for the degradation of RAS GTPases. In parallel, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638f740c019d5ee713529476708607c2
https://doi.org/10.1158/2159-8290.c.6549783.v1
https://doi.org/10.1158/2159-8290.c.6549783.v1
Autor:
Omar Abdel-Wahab, Pau Castel, R. Coleman Lindsley, Frank McCormick, Neal Rosen, Justin Taylor, Sebastien Monette, Daichi Inoue, Michael F. Walsh, Elise Fiala, Tatiana S. Pavletich, Benjamin H. Durham, Steven Tittley, Dan Cui, Michael Singer, Caroline Erickson, Hana Cho, Robert F. Stanley, Won Jun Kim, Katherine Knorr, Salima Benbarche, Eric Wang, Simon J. Hogg, Bin Lu, Antonio Cuevas-Navarro, Rahul S. Vedula, Sisi Chen
Supplementary Figure from Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b02038ca94f1d0b396e493d0f80407
https://doi.org/10.1158/2159-8290.22542018
https://doi.org/10.1158/2159-8290.22542018
Autor:
Antonio Cuevas-Navarro, Morgan Wagner, Richard Van, Monalisa Swain, Madeline R. Allison, Alice Cheng, Simon Messing, Dhirendra K. Simanshu, Matthew J. Sale, Frank McCormick, Andrew G. Stephen, Pau Castel
RIT1 belongs to the family of Ras guanosine triphosphatases (GTPases) that regulate many aspects of signal transduction and are drivers of cancer and congenital disorders.RIT1gain-of-function mutations are found in lung cancer, leukemia, and in the g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfba8fc33a2a4d5e9523d25ed398f9e4
https://doi.org/10.1101/2022.11.02.514888
https://doi.org/10.1101/2022.11.02.514888
Autor:
Antonio Cuevas-Navarro, Laura Rodriguez-Muñoz, Joaquim Grego-Bessa, Alice Cheng, Katherine A Rauen, Anatoly Urisman, Frank McCormick, Gerardo Jimenez, Pau Castel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca1812313eb189f9220d8c1e5ef1979e
https://doi.org/10.7554/elife.76495.sa2
https://doi.org/10.7554/elife.76495.sa2
Publikováno v:
Biochem J
The Biochemical journal, vol 477, iss 15
The Biochemical journal, vol 477, iss 15
RIT1 is a member of the Ras family of GTPases that direct broad cellular physiological responses through tightly controlled signaling networks. The canonical Ras GTPases are well-defined regulators of the RAF/MEK/ERK pathway and mutations in these ar
Autor:
Sisi Chen, Rahul S. Vedula, Antonio Cuevas-Navarro, Bin Lu, Simon J. Hogg, Eric Wang, Salima Benbarche, Katherine Knorr, Won Jun Kim, Robert F. Stanley, Hana Cho, Caroline Erickson, Michael Singer, Dan Cui, Steven Tittley, Benjamin H. Durham, Tatiana S. Pavletich, Elise Fiala, Michael F. Walsh, Daichi Inoue, Sebastien Monette, Justin Taylor, Neal Rosen, Frank McCormick, R. Coleman Lindsley, Pau Castel, Omar Abdel-Wahab
Publikováno v:
Cancer Discov
Cancer discovery, vol 12, iss 10
Cancer discovery, vol 12, iss 10
Recently, screens for mediators of resistance to FLT3 and ABL kinase inhibitors in leukemia resulted in the discovery of LZTR1 as an adapter of a Cullin-3 RING E3 ubiquitin ligase complex responsible for the degradation of RAS GTPases. In parallel, d
Autor:
Dominic Esposito, Dhirendra K. Simanshu, Simon Messing, Anatoly Urisman, Matthew J. Sale, Frank McCormick, Pau Castel, Gabrielle Rizzuto, Alice Cheng, Michael J. Trnka, Antonio Cuevas-Navarro, Srisathiyanarayanan Dharmaiah
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 33
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 33
RAS proteins are molecular switches that interact with effector proteins when bound to guanosine triphosphate, stimulating downstream signaling in response to multiple stimuli. Although several canonical downstream effectors have been extensively stu
Autor:
Frank McCormick, Richard Van, Pau Castel, Antonio Cuevas-Navarro, Anatoly Urisman, Alice Cheng
Publikováno v:
Curr Biol
Current biology : CB, vol 31, iss 17
Current biology : CB, vol 31, iss 17
The spindle assembly checkpoint (SAC) functions as a sensor of unattached kinetochores that delays mitotic progression into anaphase until proper chromosome segregation is guaranteed.(1,2) Disruptions to this safety mechanism lead to genomic instabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b945771c9446b502167cf3a3e68b60
https://europepmc.org/articles/PMC8440430/
https://europepmc.org/articles/PMC8440430/