Zobrazeno 1 - 10
of 336
pro vyhledávání: '"Antonio Cuadrado"'
Autor:
Christina Morgenstern, Isabel Lastres-Becker, Birsen Can Demirdöğen, Vera Marisa Costa, Andreas Daiber, Roberta Foresti, Roberto Motterlini, Sibel Kalyoncu, Burak I. Arioz, Sermin Genc, Monika Jakubowska, Ioannis P. Trougakos, Aleksandra Piechota-Polanczyk, Michel Mickael, Marlene Santos, Thomas W. Kensler, Antonio Cuadrado, Ian M. Copple
Publikováno v:
Redox Biology, Vol 72, Iss , Pp 103134- (2024)
The cytoprotective transcription factor NRF2 regulates the expression of several hundred genes in mammalian cells and is a promising therapeutic target in a number of diseases associated with oxidative stress and inflammation. Hence, an ability to mo
Externí odkaz:
https://doaj.org/article/f50d81e6b4e544bc8942767d3919a61a
Autor:
Chinmai Patibandla, Lidy van Aalten, Albena T. Dinkova-Kostova, Tadashi Honda, Antonio Cuadrado, Raquel Fernández-Ginés, Alison D. McNeilly, John D. Hayes, James Cantley, Calum Sutherland
Publikováno v:
Redox Biology, Vol 71, Iss , Pp 103117- (2024)
Accumulation of reactive oxygen species (i.e., oxidative stress) is a leading cause of beta cell dysfunction and apoptosis in diabetes. NRF2 (NF-E2 p45-related factor-2) regulates the adaptation to oxidative stress, and its activity is negatively reg
Externí odkaz:
https://doaj.org/article/174bdfaa05484649a9d4e82ff51fecbf
Autor:
Raquel Fernández-Ginés, José Antonio Encinar, Maribel Escoll, Daniel Carnicero-Senabre, José Jiménez-Villegas, Ángel J. García-Yagüe, Águeda González-Rodríguez, Irma Garcia-Martinez, Ángela M Valverde, Ana I. Rojo, Antonio Cuadrado
Publikováno v:
Redox Biology, Vol 69, Iss , Pp 103027- (2024)
Non-alcoholic steatohepatitis (NASH) is a common chronic liver disease that compromises liver function, for which there is not a specifically approved medicine. Recent research has identified transcription factor NRF2 as a potential therapeutic targe
Externí odkaz:
https://doaj.org/article/55f0658f6cd7407d98a9c86477d2e394
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102881- (2023)
Alzheimer's disease (AD) is an age-dependent neurodegenerative disorder and the most common cause of cognitive decline. The alarming epidemiological features of Alzheimer's disease, combined with the high failure rate of candidate drugs tested in the
Externí odkaz:
https://doaj.org/article/ad3ea2aca98b470d8aa8c808fb6a5417
Autor:
Antonio Cuadrado, María delBarrio, José Ignacio Fortea, Lidia Amigo, David San Segundo, María Paz Rodriguez‐Cundin, María Henar Rebollo, Roberto Fernandez‐Santiago, Federico Castillo, Maria Achalandabaso, Juan Echeverri, Edward J. Anderson, Juan Carlos Rodríguez‐Sanjuan, Marcos López‐Hoyos, Javier Crespo, Emilio Fábrega
Publikováno v:
Hepatology Communications, Vol 6, Iss 7, Pp 1673-1679 (2022)
Abstract Different reports have shown the clinical and serologic response to the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) messenger RNA (mRNA) vaccines in preventing coronavirus disease 2019 (COVID‐19) in the general populat
Externí odkaz:
https://doaj.org/article/6607835ae9d24926b0ab4967ee56b698
Autor:
Arno R. Bourgonje, Damian Kloska, Anna Grochot-Przęczek, Martin Feelisch, Antonio Cuadrado, Harry van Goor
Publikováno v:
Redox Biology, Vol 60, Iss , Pp 102603- (2023)
Inflammatory bowel diseases (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), are intimately associated with inflammation and overproduction of reactive oxygen species (ROS). Temporal and inter-individual variabilities in disease
Externí odkaz:
https://doaj.org/article/0fbaa4e93d704d2bac68dbd106eeab49
Autor:
Alejandra Palomino-Antolín, Céline Decouty-Pérez, Víctor Farré-Alins, Paloma Narros-Fernández, Ana Belen Lopez-Rodriguez, María Álvarez-Rubal, Inés Valencia, Francisco López-Muñoz, Eva Ramos, Antonio Cuadrado, Ana I. Casas, Alejandro Romero, Javier Egea
Publikováno v:
Antioxidants, Vol 12, Iss 9, p 1729 (2023)
The role of inflammation and immunity in the pathomechanism of neurodegenerative diseases has become increasingly relevant within the past few years. In this context, the NOD-like receptor protein 3 (NLRP3) inflammasome plays a crucial role in the ac
Externí odkaz:
https://doaj.org/article/552434a0330b4ac5ab6087e7cbc3bf4f
Autor:
Raquel Fernández-Ginés, José Antonio Encinar, John D. Hayes, Baldo Oliva, Maria Isabel Rodríguez-Franco, Ana I. Rojo, Antonio Cuadrado
Publikováno v:
Redox Biology, Vol 55, Iss , Pp 102428- (2022)
Externí odkaz:
https://doaj.org/article/dfa2e007ccac4a2f8c36c0c3654b1b32
Autor:
Raquel Fernández-Ginés, José Antonio Encinar, John D. Hayes, Baldo Oliva, Maria Isabel Rodríguez-Franco, Ana I. Rojo, Antonio Cuadrado
Publikováno v:
Redox Biology, Vol 55, Iss , Pp 102396- (2022)
It is widely accepted that activating the transcription factor NRF2 will blast the physiological anti-inflammatory mechanisms, which will help combat pathologic inflammation. Much effort is being put in inhibiting the main NRF2 repressor, KEAP1, with
Externí odkaz:
https://doaj.org/article/8fbf945404ce4557a8c1050e17b4a830
Autor:
Antonio Cuadrado-Lavín, José Manuel Olmos, José Manuel Cifrian, Teresa Gimenez, Marco Antonio Gandarillas, Mar García-Saiz, Maria Henar Rebollo, Victor Martínez-Taboada, Marcos López-Hoyos, María Carmen Fariñas, Javier Crespo
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-4 (2020)
Abstract Background SARS-CoV-2 infection presents a high transmission in the group of health professionals in Spain (12-15% infected). Currently there is no accepted chemoprophylaxis but hydroxychloroquine (HDQ) is known to inhibit the coronavirus in
Externí odkaz:
https://doaj.org/article/3faf183478664a3981d246772da1ae94