Zobrazeno 1 - 10
of 276
pro vyhledávání: '"Antonio C, Bianco"'
Autor:
Fabyan Esberard de Lima Beltrão, Daniele Carvalhal de Almeida Beltrão, Giulia Carvalhal, Fabyanna Lethicia de Lima Beltrão, Jocyel de Brito Oliveira, Hatilla dos Santos Silva, Helena Mariana Pitangueira Teixeira, Juliana Lopes Rodrigues, Camila Alexandrina Viana de Figueiredo, Ryan dos Santos Costa, Fabio Hecht, Giciane Carvalho Vieira, Maria da Conceição Rodrigues Gonçalves, Antonio C. Bianco, Helton Estrela Ramos
Publikováno v:
European Thyroid Journal, Vol 13, Iss 4, Pp 1-12 (2024)
Introduction: The type 2 deiodinase and its Thr92Ala-DIO2 polymorphism have been linked to clinical outcomes in acute lung injury and coronavirus disease 2019 (COVID-19). Objective: The objective was to identify a potential association between Thr92A
Externí odkaz:
https://doaj.org/article/4949abe373b64421b8c369579539d361
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/567cd549a7e944208f255c0976e8248e
Autor:
Jorge Hidalgo-Álvarez, Federico Salas-Lucia, Diana Vera Cruz, Tatiana L. Fonseca, Antonio C. Bianco
Publikováno v:
JCI Insight, Vol 8, Iss 23 (2023)
Thyroid hormone (TH) levels are low during development, and the deiodinases control TH signaling through tissue-specific activation or inactivation of TH. Here, we studied human induced pluripotent stem cell–derived (iPSC-derived) hepatic organoids
Externí odkaz:
https://doaj.org/article/05f8ed20b1f64a88bb8b6573a1c37aa9
Autor:
Federico Salas-Lucia, Csaba Fekete, Richárd Sinkó, Péter Egri, Kristóf Rada, Yvette Ruska, Balázs Gereben, Antonio C Bianco
Publikováno v:
eLife, Vol 12 (2023)
The development of the brain, as well as mood and cognitive functions, are affected by thyroid hormone (TH) signaling. Neurons are the critical cellular target for TH action, with T3 regulating the expression of important neuronal gene sets. However,
Externí odkaz:
https://doaj.org/article/b946576031f9450faad9f68988ff69ea
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
The clinical availability of tissue-specific biomarkers of thyroid hormone (TH) action constitutes a “holy grail” for the field. Scientists have investigated several TH-dependent markers, including the tissue content of triiodothyronine (T3)—th
Externí odkaz:
https://doaj.org/article/cc0accf36dcd4859b82fee2b710e9541
Autor:
Tatiana L. Fonseca, Tzintzuni Garcia, Gustavo W. Fernandes, T. Murlidharan Nair, Antonio C. Bianco
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Whether thyroid hormones affect gene expression via DNA methylation is not well known. Here the authors show that type 2 deiodinase (D2) converts T4 to produce T3, which prevents DNA methylation of discrete areas in the neonatal liver. In the absence
Externí odkaz:
https://doaj.org/article/5587b3ecf19b472a84494cfe82d8da0a
Autor:
Natalie C. Butterfield, Katherine F. Curry, Julia Steinberg, Hannah Dewhurst, Davide Komla-Ebri, Naila S. Mannan, Anne-Tounsia Adoum, Victoria D. Leitch, John G. Logan, Julian A. Waung, Elena Ghirardello, Lorraine Southam, Scott E. Youlten, J. Mark Wilkinson, Elizabeth A. McAninch, Valerie E. Vancollie, Fiona Kussy, Jacqueline K. White, Christopher J. Lelliott, David J. Adams, Richard Jacques, Antonio C. Bianco, Alan Boyde, Eleftheria Zeggini, Peter I. Croucher, Graham R. Williams, J. H. Duncan Bassett
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Osteoarthritis is a chronic, heritable disease with no available treatment. Here, the authors show that a validated, rapid-throughput joint phenotyping pipeline detects osteoarthritis in the mouse knee following surgical provocation, in aging and aft
Externí odkaz:
https://doaj.org/article/edbe1f565dfb4cb59b5b96ecd707f7bc
Autor:
Fernanda B. Lorena, Juliana M. Sato, Beatriz Martin Coviello, Alexandre J. T. Arnold, Alice Batistuzzo, Laís M. Yamanouchi, Eduardo Dias Junior, Bruna P. P. do Nascimento, Tatiana de L. Fonseca, Antonio C. Bianco, Miriam O. Ribeiro
Publikováno v:
Metabolites, Vol 12, Iss 7, p 629 (2022)
The Thr92Ala-Dio2 polymorphism has been associated with reduced cognition in 2-month-old male mice and increased risk for cognitive impairment and Alzheimer’s disease in African Americans. This has been attributed to reduced thyroid hormone (TH) si
Externí odkaz:
https://doaj.org/article/dc73b6f076b54ed592ad014f4608d1b0
Autor:
Gustavo W. Fernandes, Barbara M.L.C. Bocco, Tatiana L. Fonseca, Elizabeth A. McAninch, Sungro Jo, Lattoya J. Lartey, InSug O-Sullivan, Terry G. Unterman, Nailliw Z. Preite, Robin M. Voigt, Christopher B. Forsyth, Ali Keshavarzian, Richárd Sinkó, Allison B. Goldfine, Mary E. Patti, Miriam O. Ribeiro, Balázs Gereben, Antonio C. Bianco
Publikováno v:
Cell Reports, Vol 22, Iss 2, Pp 523-534 (2018)
Summary: Liver-specific disruption of the type 2 deiodinase gene (Alb-D2KO) results in resistance to both diet-induced obesity and liver steatosis in mice. Here, we report that this is explained by an ∼60% reduction in liver zinc-finger protein-125
Externí odkaz:
https://doaj.org/article/a4785ccf0adc442d8ad47261ca8b28e7
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
The standard of care to treat hypothyroidism is daily administration of levo-thyroxine (LT4). This is based on the understanding that deiodinases can restore production of T3 and compensate for the small amounts of T3 that are normally produced by th
Externí odkaz:
https://doaj.org/article/13fc8cc179af40a3a9f5b7f3157a36b1