Hyperactive HRAS dysregulates energetic metabolism in fibroblasts from patients with Costello syndrome via enhanced production of reactive oxidizing species

Autor: Laura Mercurio, Francesca Megiorni, Chiara Leoni, Daniele Pietrucci, Teresa Rizza, Egidio Iorio, Giuseppe Zampino, Giovanna Carpentieri, Massimo Tatti, Simona Camero, Serena Cecchetti, Elisabetta Flex, Roberta Onesimo, Giovanni Chillemi, Cinzia Marchese, Valentina Tirelli, Donatella Pietraforte, Rosalba Carrozzo, Sara Rinalducci, Michela Di Nottia, Deborah Pajalunga, Antonio Belardo, Marco Tartaglia

Publikováno v: Human Molecular Genetics. 31:561-575

Germline-activating mutations in HRAS cause Costello syndrome (CS), a cancer prone multisystem disorder characterized by reduced postnatal growth. In CS, poor weight gain and growth are not caused by low caloric intake. Here, we show that constitutiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d78c26b3094248ad82925be380ac68
https://doi.org/10.1093/hmg/ddab270

From Targeted Quantification to Untargeted Metabolomics

Autor: Antonio Belardo, Anna Maria Timperio, Veronica Lelli

Metabolomics is an emerging and rapidly evolving technology tool, which involves quantitative and qualitative metabolite assessments science. It offers tremendous promise for different applications in various fields such as medical, environmental, nu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3569d7f60facb9615ba269cc269f966
https://doi.org/10.5772/intechopen.96852

ALS skin fibroblasts reveal oxidative stress and ERK1/2-mediated cytoplasmic localization of TDP-43

Autor: Laura Bertini, Mario Sabatelli, Kristy Welshhans, Nicla Romano, Elisabetta Catalani, Federica Silvestri, Davide Cervia, Silvia Proietti, Alessia Catalani, Serena Lattante, Marcello Ceci, Antonio Belardo, Lello Zolla

The main hallmark of many forms of familiar and sporadic amyotrophic lateral sclerosis (ALS) is a reduction in nuclear TDP-43 protein and its inclusion in cytoplasmic aggregates in motor neurons. In order to understand which cellular and molecular me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b4c0dc37c04bd510f6acf0ee993334
http://hdl.handle.net/10807/147258

GLYI4 Plays A Role in Methylglyoxal Detoxification and Jasmonate-Mediated Stress Responses in Arabidopsis thaliana

Autor: Ivan Baccelli, Gaia Salvatore Falconieri, Carla Caruso, Laura Bertini, Antonio Belardo, Silvia Proietti, Anna Maria Timperio, Elena Paccosi

Publikováno v: Biomolecules, Vol 9, Iss 10, p 635 (2019)
Biomolecules
Volume 9
Issue 10
Biomolecules 9 (2019). doi:10.3390/biom9100635
info:cnr-pdr/source/autori:Proietti S., Falconieri G.S., Bertini L., Baccelli I., Paccosi E., Belardo A., Timperio A.M., Caruso C./titolo:GLYI4 Plays A Role in Methylglyoxal Detoxification and Jasmonate-Mediated Stress Responses in Arabidopsis thaliana/doi:10.3390%2Fbiom9100635/rivista:Biomolecules/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:9

Plant hormones play a central role in various physiological functions and in mediating defense responses against (a)biotic stresses. In response to primary metabolism alteration, plants can produce also small molecules such as methylglyoxal (MG), a c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078f26fef58667e045e6df2521482778
https://www.mdpi.com/2218-273X/9/10/635