Enhancer-associated H3K4 methylation safeguards in vitro germline competence

Autor: Tore Bleckwehl, Giuliano Crispatzu, Kaitlin Schaaf, Patricia Respuela, Michaela Bartusel, Laura Benson, Stephen J. Clark, Kristel M. Dorighi, Antonio Barral, Magdalena Laugsch, Wilfred F. J. van IJcken, Miguel Manzanares, Joanna Wysocka, Wolf Reik, Álvaro Rada-Iglesias

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

While inductive signals controlling germline specification are well characterized, the intrinsic factors that allow epiblast cells to respond to such signals remain largely unknown. Here the authors use in vitro differentiated primordial germ cells t

Externí odkaz: https://doaj.org/article/bf07c5a2a44549a9aca337c37d7cef97

Pluripotency factors regulate the onset of

Autor: María, Tiana, Elena, Lopez-Jimenez, Julio Sainz, de Aja, Antonio, Barral, Jesus, Victorino, Claudio, Badia-Careaga, Isabel, Rollan, Raquel, Rouco, Elisa, Santos, Hector, Sanchez-Iranzo, Rafael D, Acemel, Carlos, Torroja, Javier, Adan, Eduardo, Andres-Leon, Jose Luis, Gomez-Skarmeta, Giovanna, Giovinazzo, Fatima, Sanchez-Cabo, Miguel, Manzanares

Publikováno v: Science advances. 8(28)

Pluripotent cells are a transient population of the mammalian embryo dependent on transcription factors, such as OCT4 and NANOG, which maintain pluripotency while suppressing lineage specification. However, these factors are also expressed during ear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::df1b5c9136f796aba27bfff5caa219cf
https://pubmed.ncbi.nlm.nih.gov/35857513

Enhancer-associated H3K4 methylation safeguards in vitro germline competence

Autor: Wolf Reik, Wilfred F. J. van IJcken, Joanna Wysocka, Kristel M. Dorighi, Miguel Manzanares, Giuliano Crispatzu, Michaela Bartusel, Alvaro Rada-Iglesias, Magdalena Laugsch, Tore Bleckwehl, Stephen J. Clark, Kaitlin Schaaf, Antonio Barral, Laura Benson, Patricia Respuela

Publikováno v: Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, 12(1):5771. Nature Publishing Group

© The Author(s) 2021.
Germline specification in mammals occurs through an inductive process whereby competent cells in the post-implantation epiblast differentiate into primordial germ cells (PGC). The intrinsic factors that endow epiblast cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ded7b36929fa7f195f3e15b41bf9f88

Nanog regulates Pou3f1 expression at the exit from pluripotency during gastrulation

Autor: Isabel Rollan, Berthold Göttgens, Sergio Menchero, Héctor Sánchez-Iranzo, Carlos Torroja, Miguel Manzanares, Claudio Badia-Careaga, Julio Sainz de Aja, Manuel Gómez, Antonio Barral, Wajid Jawaid, Fátima Sánchez-Cabo

Publikováno v: Biology Open
Biology Open, Vol 8, Iss 11 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Repisalud
Instituto de Salud Carlos III (ISCIII)

Pluripotency is regulated by a network of transcription factors that maintain early embryonic cells in an undifferentiated state while allowing them to proliferate. NANOG is a critical factor for maintaining pluripotency and its role in primordial ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a92a3377241c2ccf800a6a84d8c7baa
http://hdl.handle.net/10261/215090

La reforma de las rentas contingentes en los arrendamientos. (Spanish)

Autor: Rivada, Antonio Barral, Sánchez, Horacio Molina, Sobrino, Jesús N. Ramírez

Publikováno v: Partida Doble; May2012, Vol. 23 Issue 243, p22-38, 17p