First person – Antonio Barral and Isabel Rollan

Publikováno v: Biology Open, Vol 8, Iss 11 (2019)

First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Antonio Barral and Isabel Rollan are co-first authors on ‘

Externí odkaz: https://doaj.org/article/b05bb9318cb94f2d81d1549664cd5f6a

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Nanog regulates Pou3f1 expression at the exit from pluripotency during gastrulation

Autor: Antonio Barral, Isabel Rollan, Hector Sanchez-Iranzo, Wajid Jawaid, Claudio Badia-Careaga, Sergio Menchero, Manuel J. Gomez, Carlos Torroja, Fatima Sanchez-Cabo, Berthold Göttgens, Miguel Manzanares, Julio Sainz de Aja

Publikováno v: Biology Open, Vol 8, Iss 11 (2019)

Pluripotency is regulated by a network of transcription factors that maintain early embryonic cells in an undifferentiated state while allowing them to proliferate. NANOG is a critical factor for maintaining pluripotency and its role in primordial ge

Externí odkaz: https://doaj.org/article/7b04155c14a14dc0b9c431f9d6d5fc05

Pluripotency factors regulate the onset of Hox cluster activation in the early embryo

Autor: José Luis Gómez-Skarmeta, Elena López-Jiménez, Fátima Sánchez-Cabo, Héctor Sánchez-Iranzo, Jesus Victorino, Julio Sainz de Aja, Miguel Manzanares, Isabel Rollan, Antonio Barral, Javier Adan, Elisa Santos, Eduardo Andres-Leon, Maria Tiana, Giovanna Giovinazzo, Carlos Torroja, Rafael D. Acemel, Claudio Badia-Careaga, Raquel Rouco

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Science Advances, 8 (28), 1-13

Pluripotent cells are a transient population of the mammalian embryo dependent on transcription factors, such as OCT4 and NANOG, which maintain pluripotency while suppressing lineage specification. However, these factors are also expressed during ear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d12191f6ce3a66e5888efa38bfa42c8
https://hdl.handle.net/20.500.12105/15648

Enhancer-associated H3K4 methylation safeguards in vitro germline competence

Autor: Wolf Reik, Wilfred F. J. van IJcken, Joanna Wysocka, Kristel M. Dorighi, Miguel Manzanares, Giuliano Crispatzu, Michaela Bartusel, Alvaro Rada-Iglesias, Magdalena Laugsch, Tore Bleckwehl, Stephen J. Clark, Kaitlin Schaaf, Antonio Barral, Laura Benson, Patricia Respuela

Publikováno v: Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
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Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, 12(1):5771. Nature Publishing Group

© The Author(s) 2021.
Germline specification in mammals occurs through an inductive process whereby competent cells in the post-implantation epiblast differentiate into primordial germ cells (PGC). The intrinsic factors that endow epiblast cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ded7b36929fa7f195f3e15b41bf9f88