Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Antonio Alcamí"'
Autor:
David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E. Jørgensen, Michelle Thomsen, Line S. Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H. Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G. Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Jakobsen, Esben B. Svenningsen, Thomas B. Poulsen, Lydia Bartsch, Anne L. Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcamí, John Hiscott, Trine H. Mogensen, Søren R. Paludan, Christian K. Holm
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Viral infections usually cause disease through direct cytopathogenic effects and excessive inflammatory responses. Here, Olagnier et al. show that two NRF2 agonists, 4-OI and DMF, possess broad IFN-independent antiviral activity and decrease host inf
Externí odkaz:
https://doaj.org/article/7eb1ed3741cc4fbfa366937b0037cc35
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009541 (2021)
Herpes simplex virus type 1 and 2 (HSV-1 and HSV-2, respectively) are prevalent human pathogens of clinical relevance that establish long-life latency in the nervous system. They have been considered, along with the Herpesviridae family, to exhibit a
Externí odkaz:
https://doaj.org/article/f6582980350742a086b7ba9f06397297
Autor:
Bruno Hernáez, Juan Manuel Alonso-Lobo, Imma Montanuy, Cornelius Fischer, Sascha Sauer, Luis Sigal, Noemí Sevilla, Antonio Alcamí
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Secreted cytokine decoy receptors encoded by viruses can act as potent immune evasion proteins modulating antiviral immunity. Here Hernaez et al. show that cell surface binding is required for efficient evasion of the host response by a secreted viru
Externí odkaz:
https://doaj.org/article/1dfee90d8c3a4e8582932ce956159076
Autor:
Jennifer Becker, Volker Kinast, Marius Döring, Christoph Lipps, Veronica Duran, Julia Spanier, Pia-Katharina Tegtmeyer, Dagmar Wirth, Luka Cicin-Sain, Antonio Alcamí, Ulrich Kalinke
Publikováno v:
Virulence, Vol 9, Iss 1, Pp 1669-1684 (2018)
Infection of healthy individuals with human cytomegalovirus (HCMV) is usually unnoticed and results in life-long latency, whereas HCMV reactivation as well as infection of newborns or immunocompromised patients can cause life-threatening disease. To
Externí odkaz:
https://doaj.org/article/75d5d2ba3cc044869f2754e82d343775
Autor:
Alí Alejo, M. Begoña Ruiz-Argüello, Sergio M. Pontejo, María del Mar Fernández de Marco, Margarida Saraiva, Bruno Hernáez, Antonio Alcamí
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Cytokines play critical roles in the anti-viral response but their contribution in vivo remains unclear. Here the authors show that viral CrmD is a major virulence determinant and requires the SECRET and TNF binding domains to counter both the chemok
Externí odkaz:
https://doaj.org/article/0f471da0fe0f47cfb7468c4516c8b948
Publikováno v:
Pathogens, Vol 10, Iss 8, p 1065 (2021)
Tumour necrosis factor (TNF) is an inflammatory cytokine produced in response to viral infections that promotes the recruitment and activation of leukocytes to sites of infection. This TNF-based host response is essential to limit virus spreading, th
Externí odkaz:
https://doaj.org/article/194c85d2b226405985b012bd34aed52b
Publikováno v:
Viruses, Vol 13, Iss 6, p 1146 (2021)
Ectromelia virus (ECTV), the causative agent of mousepox, has threatened laboratory mouse colonies worldwide for almost a century. Mousepox has been valuable for the understanding of poxvirus pathogenesis and immune evasion. Here, we have monitored i
Externí odkaz:
https://doaj.org/article/3141def5a16f4780b2dd49e4c6967c54
Autor:
Pablo Martínez-Vicente, Domènec Farré, Carolina Sánchez, Antonio Alcamí, Pablo Engel, Ana Angulo
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007658 (2019)
Throughout evolution, cytomegaloviruses (CMVs) have been capturing genes from their hosts, employing the derived proteins to evade host immune defenses. We have recently reported the presence of a number of CD48 homologs (vCD48s) encoded by different
Externí odkaz:
https://doaj.org/article/aeee2b860bd94e99af5505b31cd789f8
Autor:
David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E. Jørgensen, Michelle Thomsen, Line S. Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H. Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G. Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Jakobsen, Esben B. Svenningsen, Thomas B. Poulsen, Lydia Bartsch, Anne L. Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcamí, John Hiscott, Trine H. Mogensen, Søren R. Paludan, Christian K. Holm
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/7a767ab0a50943a0a5a6e85eaa10ccfe
Autor:
José Manuel Rojas, Alí Alejo, Jose Miguel Avia, Daniel Rodríguez-Martín, Carolina Sánchez, Antonio Alcamí, Noemí Sevilla, Verónica Martín
Publikováno v:
Vaccines, Vol 8, Iss 2, p 333 (2020)
Members of the tumour necrosis factor (TNF) superfamily OX40L and CD70 and their receptors are costimulating signalling axes critical for adequate T cell activation in humans and mice but characterisation of these molecules in other species including
Externí odkaz:
https://doaj.org/article/67f2753b3a554ab7a060cd6ccffe04ac