Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Antonio Alarcon Miguez"'
Publikováno v:
Current Opinion in Chemical Engineering. 22:71-80
Meeting the metabolic demands of Chinese hamster ovary (CHO) cells has been an area of intense investigation over the last 3 decades as a means to improve these cell factories as producers of high quality recombinant therapeutic proteins. Metabolical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6e9b1c7294006464f56dd266ba1f002
https://doi.org/10.1016/j.coche.2018.08.009
https://doi.org/10.1016/j.coche.2018.08.009
Autor:
Padraig Doolan, Antonio Alarcon Miguez, Joanne Keenan, Srinivas Suda, Martin Clynes, Berta Capella Roca, Niall Barron, Donal J. O’Gorman
Publikováno v:
Cytotechnology
In order to study the impact of zinc and copper on the titer levels of mAb and recombinant protein in CHO cells, the IgG-expressing (DP12) and EPO-expressing (SK15) cell lines were cultured in chemically defined media with increasing concentrations o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460bceaa612956c4e4dd524c9d2de345
https://pubmed.ncbi.nlm.nih.gov/31396753
https://pubmed.ncbi.nlm.nih.gov/31396753
Autor:
Christine Ta, Antonio Alarcon Miguez, Jonathan Bones, Paul S. Kelly, Sara Carillo, Emma Harper, Michael Henry, Orla Coleman, Martin Clynes, Paula Meleady, Noemí Dorival-García, Samantha Paré, Niall Barron, Lisa Connolly, Maeve Shannon
Publikováno v:
Harper, E, Connolly, L, Kelly, P S, Dorival-García, N, Paré, S, Carillo, S, Ta, C, Alarcon Miguez, A, Coleman, O, Shannon, M, Henry, M, Clynes, M, Meleady, P, Bones, J & Barron, N 2019, ' Improvements in single-use bioreactor film material composition leads to robust and reliable Chinese hamster ovary cell performance ', Biotechnology Progress, vol. 35, no. 4, 35, pp. e2824 . https://doi.org/10.1002/btpr.2824, https://doi.org/10.1002/btpr.2824
Single‐use technologies, in particular disposable bioreactor bags, have become integral within the biopharmaceutical community. However, safety concerns arose upon the identification of toxic leachable compounds derived from the plastic materials.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a296f3daa7ff5d76f21617f7dbc60c2a
https://pubmed.ncbi.nlm.nih.gov/31017345
https://pubmed.ncbi.nlm.nih.gov/31017345