Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Antonio Adamo"'
Autor:
Veronica Astro, Elisabetta Fiacco, Kelly Johanna Cardona-Londoño, Ilario De Toma, Hams Saeed Alzahrani, Jumana Alama, Amal Kokandi, Taha Abo-Almagd Abdel-Meguid Hamoda, Majed Felemban, Antonio Adamo
Publikováno v:
Endocrine Connections, Vol 12, Iss 5, Pp 1-12 (2023)
Objective: The transcriptional landscape of Klinefelter syndrome (KS) during early embryogenesis remains elusive. This study aimed to evaluate the impact of X chromosome overdosage in 47,XXY males induced pluripotent stem cells (iPSCs) obtained from
Externí odkaz:
https://doaj.org/article/e458266cbab54a838ebbd856aaec132c
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102252- (2023)
Summary: The derivation of cardiomyocytes from human pluripotent stem cells (hPSCs) is a powerful tool to investigate early cardiogenesis and model diseases in vitro. Here, we present an optimized protocol to obtain contracting hPSCs-derived cardiomy
Externí odkaz:
https://doaj.org/article/51f1153d4f064e38bd52e6c452f567ae
Autor:
Veronica Astro, Gustavo Ramirez-Calderon, Roberta Pennucci, Jonatan Caroli, Alfonso Saera-Vila, Kelly Cardona-Londoño, Chiara Forastieri, Elisabetta Fiacco, Fatima Maksoud, Maryam Alowaysi, Elisa Sogne, Andrea Falqui, Federico Gonzàlez, Nuria Montserrat, Elena Battaglioli, Andrea Mattevi, Antonio Adamo
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104665- (2022)
Summary: The histone demethylase KDM1A is a multi-faceted regulator of vital developmental processes, including mesodermal and cardiac tube formation during gastrulation. However, it is unknown whether the fine-tuning of KDM1A splicing isoforms, alre
Externí odkaz:
https://doaj.org/article/8a70120d84cb4d15af6742085771f118
Autor:
Veronica Astro, Maryam Alowaysi, Elisabetta Fiacco, Alfonso Saera-Vila, Kelly J. Cardona-Londoño, Riccardo Aiese Cigliano, Antonio Adamo
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
Klinefelter syndrome (KS) is the most prevalent aneuploidy in males and is characterized by a 47,XXY karyotype. Less frequently, higher grade sex chromosome aneuploidies (HGAs) can also occur. Here, using a paradigmatic cohort of KS and HGA induced p
Externí odkaz:
https://doaj.org/article/d0e334e15a954139845c1e175e48f730
Autor:
Gustavo Ramirez-Calderon, Giovanni Colombo, Carlos A. Hernandez-Bautista, Veronica Astro, Antonio Adamo
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Human pluripotent stem cells (hPSCs) constitute a valuable model to study the complexity of early human cardiac development and investigate the molecular mechanisms involved in heart diseases. The differentiation of hPSCs into cardiac lineages in vit
Externí odkaz:
https://doaj.org/article/95be3f6116ad4b74aeae92a6720373ee
Publikováno v:
Stem Cell Research, Vol 50, Iss , Pp 102119- (2021)
Klinefelter Syndrome (KS) is the most common X chromosome aneuploidy in males characterized by highly heterogeneous clinical manifestations including a subtle cognitive impairment and multisystemic disorders such as infertility, metabolic syndrome, g
Externí odkaz:
https://doaj.org/article/49272b3fad3349a19b04994ccba89dfb
Autor:
Maryam Alowaysi, Veronica Astro, Elisabetta Fiacco, Fatema Alzahrani, Fowzan S. Alkuraya, Antonio Adamo
Publikováno v:
Stem Cell Research, Vol 50, Iss , Pp 102148- (2021)
Glucagon-like peptide-1 receptor (GLP1R) is a seven-transmembrane-spanning helices membrane protein expressed in multiple human tissues including pancreatic islets, lung, brain, heart and central nervous system (CNS). GLP1R agonists are commonly used
Externí odkaz:
https://doaj.org/article/37d2f17810c8471e86f6a0389d8a8f7e
Publikováno v:
Stem Cell Research, Vol 49, Iss , Pp 102008- (2020)
Klinefelter Syndrome (KS) is the most frequent X chromosome aneuploidy in males. KS patients with 47-XXY, 48-XXXY and 49-XXXXY karyotypes endure inter-individual phenotypic variabilities including infertility, cardiac diseases, metabolic and psychiat
Externí odkaz:
https://doaj.org/article/96dc725ada1546138a8e4755a6917556
Publikováno v:
Stem Cell Research, Vol 49, Iss , Pp 102042- (2020)
Klinefelter Syndrome (KS) is caused by the presence of a supernumerary X chromosome. Cytogenetic studies revaled that 80–90% of patients carry a 47-XXY karyotype, while 10–20% of cases are represented by mosaic 46-XY/47-XXY and high-grade aneuplo
Externí odkaz:
https://doaj.org/article/7a0d6d32d9da48b382224d6960f177ec
Publikováno v:
Stem Cell Research, Vol 49, Iss , Pp 102049- (2020)
While Klinefelter Syndrome (KS) has a prevalence of 85–250 per 100,000 born males, patients are typically underdiagnosed due to a subtle phenotype emerging only late during puberty or adulthood. Rare cases of KS carry a mosaic phenotype 47-XXY/46-X
Externí odkaz:
https://doaj.org/article/7a1522921c4b4e189dd95379688ab50d