Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Antonio A W L, Wong"'
Autor:
Arsyangela Verena, Helen Merkens, Chao-Cheng Chen, Devon E. Chapple, Lei Wang, Shreya Bendre, Antonio A. W. L. Wong, François Bénard, Kuo-Shyan Lin
Publikováno v:
Molecules, Vol 29, Iss 4, p 800 (2024)
Some bispecific radiotracers have been developed to overcome the limitations of monospecific tracers and improve detection sensitivity for heterogeneous tumor lesions. Here, we aim to synthesize two bispecific tracers targeting prostate-specific memb
Externí odkaz:
https://doaj.org/article/faeba61c8ec04d788d0dcd4a501cd17d
Autor:
Shreya Bendre, Hsiou-Ting Kuo, Helen Merkens, Zhengxing Zhang, Antonio A. W. L. Wong, François Bénard, Kuo-Shyan Lin
Publikováno v:
Pharmaceuticals, Vol 16, Iss 6, p 798 (2023)
Fibroblast activation protein (FAP) is a membrane-tethered serine protease overexpressed in the reactive stromal fibroblasts of >90% human carcinomas, which makes it a promising target for developing radiopharmaceuticals for the imaging and therapy o
Externí odkaz:
https://doaj.org/article/18c7ab88e11c4809acde95fb280becf0
Autor:
Shreya Bendre, Zhengxing Zhang, Nadine Colpo, Jutta Zeisler, Antonio A. W. L. Wong, François Bénard, Kuo-Shyan Lin
Publikováno v:
Molecules, Vol 28, Iss 8, p 3481 (2023)
Fibroblast activation protein α (FAP-α) is a cell-surface protein overexpressed on cancer-associated fibroblasts that constitute a substantial component of tumor stroma and drive tumorigenesis. FAP is minimally expressed by most healthy tissues, in
Externí odkaz:
https://doaj.org/article/5a8504142a36492583ea20465ed91249
Autor:
Arsyangela Verena, Hsiou-Ting Kuo, Helen Merkens, Jutta Zeisler, Shreya Bendre, Antonio A. W. L. Wong, François Bénard, Kuo-Shyan Lin
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 449 (2023)
Compared to quinoline-based fibroblast activation protein (FAP)-targeted radiotracers, pyridine-based FAP-targeted tracers are expected to have faster pharmacokinetics due to their smaller molecular size and higher hydrophilicity, which we hypothesiz
Externí odkaz:
https://doaj.org/article/26ab9e7cafce478086200098b3ddc317
Autor:
Arsyangela Verena, Zhengxing Zhang, Hsiou-Ting Kuo, Helen Merkens, Jutta Zeisler, Ryan Wilson, Shreya Bendre, Antonio A. W. L. Wong, François Bénard, Kuo-Shyan Lin
Publikováno v:
Molecules, Vol 28, Iss 3, p 1088 (2023)
Tumor heterogeneity limits the efficacy and reliability of monospecific radiopharmaceuticals in prostate cancer diagnosis and therapy. To overcome this limitation and improve lesion detection sensitivity, we developed and evaluated three bispecific r
Externí odkaz:
https://doaj.org/article/eb122ae3a6a84703bf06a1e06f36ea31
Autor:
Torsten Hechler, Andreas Pahl, Alexandra Braun, Kaveh Matinkhoo, Brandon Kato, Christoph Müller, Francesca Gallo, Antonio A. W. L. Wong, Charlie Wei, Chido M. Hambira, David M. Perrin
Publikováno v:
Chemistry – A European Journal. 27:10282-10292
Alpha-amanitin, an extremely toxic bicyclic octapeptide extracted from the death-cap mushroom, Amanita phalloides, is a highly selective allosteric inhibitor of RNA polymerase II. Following on growing interest in using this toxin as a payload in anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b587e201695d766cc78b2c5bffd77115
https://doi.org/10.1002/chem.202101373
https://doi.org/10.1002/chem.202101373
Autor:
Mihajlo Todorovic, Paul Rivollier, Antonio A. W. L. Wong, Zhou Wang, Alla Pryyma, Tuan Trung Nguyen, Kayla C. Newell, Juliette Froelich, David M. Perrin
Publikováno v:
Journal of medicinal chemistry. 65(15)
For 70 years, α-amanitin, the most cytotoxic peptide in its class, has been without a synthetic rival; through synthesis, we address the structure-activity relationships to inform the design of new amatoxins and disclose analogues that are more cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49543a0f84695a59e77bf9210066ab09
https://pubmed.ncbi.nlm.nih.gov/35696491
https://pubmed.ncbi.nlm.nih.gov/35696491
Autor:
David M. Perrin, Antonio A. W. L. Wong, Helen Merkens, Kuo-Shyan Lin, Chengcheng Zhang, Mathieu L. Lepage, Jutta Zeisler, Jerome Lozada, Francois Benard
Publikováno v:
RSC Medicinal Chemistry. 11:569-576
In pursuit of 18F-labeled nucleosides for positron emission tomography (PET) imaging, we report on the chemical and radiochemical synthesis of two thymidine (dT) analogs, dT-C5-AMBF3 and dT-N3-AMBF3, that are radiofluorinated by isotope exchange (IEX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07ba1843fa9ef69a50952f93fe43db4c
https://doi.org/10.1039/d0md00054j
https://doi.org/10.1039/d0md00054j
Publikováno v:
ChemBioChem. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f973465b94c7784605051e0b8c130c0
https://doi.org/10.1002/cbic.202100600
https://doi.org/10.1002/cbic.202100600
Publikováno v:
Chembiochem : a European journal of chemical biology. 23(5)
Sequence-specific cleavage of RNA by nucleic acid catalysts in the absence of a divalent metal cation (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::741339bf28d1d8b0f48e122e60f4d64e
https://pubmed.ncbi.nlm.nih.gov/34881502
https://pubmed.ncbi.nlm.nih.gov/34881502