Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Antonio De Flora"'
Autor:
Andrea Benzi, Markus Heine, Sonia Spinelli, Annalisa Salis, Anna Worthmann, Björn Diercks, Cecilia Astigiano, Raúl Pérez Mato, Adela Memushaj, Laura Sturla, Valerio Vellone, Gianluca Damonte, Michelle Y. Jaeckstein, Friedrich Koch-Nolte, Hans-Willi Mittrücker, Andreas H. Guse, Antonio De Flora, Joerg Heeren, Santina Bruzzone
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2024)
IntroductionDuring thermogenesis, adipose tissue (AT) becomes more active and enhances oxidative metabolism. The promotion of this process in white AT (WAT) is called “browning” and, together with the brown AT (BAT) activation, is considered as a
Externí odkaz:
https://doaj.org/article/6cbc007a0f474be38c4530fd56e6e433
Autor:
Elena Abbotto, Caterina Miro, Francesco Piacente, Annalisa Salis, Melania Murolo, Annarita Nappi, Enrico Millo, Eleonora Russo, Elena Cichero, Laura Sturla, Alberto Del Rio, Antonio De Flora, Alessio Nencioni, Monica Dentice, Santina Bruzzone
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 166, Iss , Pp 115326- (2023)
Sirtuin 6 (SIRT6) has a critical role in cutaneous Squamous Cell Carcinoma (cSCC): SIRT6 silencing in skin SCC cells has pro-differentiating effects and SIRT6 deletion abrogated DMBA-TPA-induced skin tumorigenesis in mice. On the other hand, SIRT6 ac
Externí odkaz:
https://doaj.org/article/487ea97481c846938c17d04b08a92400
Autor:
Cecilia Astigiano, Francesco Piacente, Maria Elena Laugieri, Andrea Benzi, Christian A. Di Buduo, Carolina P. Miguel, Debora Soncini, Michele Cea, Antonella Antonelli, Mauro Magnani, Alessandra Balduini, Antonio De Flora, Santina Bruzzone
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6759 (2023)
Sirtuin 6 (SIRT6) is a member of the mammalian NAD+-dependent deac(et)ylase sirtuin family. SIRT6’s anti-inflammatory roles are emerging increasingly often in different diseases and cell types, including endothelial cells. In this study, the role o
Externí odkaz:
https://doaj.org/article/9aea6083f9c84c3b9c7ccede3d20014f
Autor:
Pamela Becherini, Debora Soncini, Silvia Ravera, Elisa Gelli, Claudia Martinuzzi, Giulia Giorgetti, Antonia Cagnetta, Fabio Guolo, Federico Ivaldi, Maurizio Miglino, Sara Aquino, Katia Todoerti, Antonino Neri, Andrea Benzi, Mario Passalacqua, Alessio Nencioni, Ida Perrotta, Maria Eugenia Gallo Cantafio, Nicola Amodio, Antonio De Flora, Santina Bruzzone, Roberto M. Lemoli, Michele Cea
Publikováno v:
Antioxidants, Vol 12, Iss 2, p 494 (2023)
Cancer cells fuel growth and energy demands by increasing their NAD+ biosynthesis dependency, which therefore represents an exploitable vulnerability for anti-cancer strategies. CD38 is a NAD+-degrading enzyme that has become crucial for anti-MM ther
Externí odkaz:
https://doaj.org/article/0e796c050e73475a981a9b6091ebf662
Role of Liver CD38 in the Regulation of Metabolic Pathways during Cold-Induced Thermogenesis in Mice
Autor:
Andrea Benzi, Sonia Spinelli, Laura Sturla, Markus Heine, Alexander W. Fischer, Friedrich Koch-Nolte, Hans-Willi Mittrücker, Andreas H. Guse, Antonio De Flora, Joerg Heeren, Santina Bruzzone
Publikováno v:
Cells, Vol 11, Iss 23, p 3812 (2022)
Boosting NAD+ levels are considered a promising means to promote healthy aging and ameliorate dysfunctional metabolism. The expression of CD38, the major NAD+-consuming enzyme, is downregulated during thermogenesis in both brown and white adipose tis
Externí odkaz:
https://doaj.org/article/2bbe202a521248858605b5a7300a8e0b
Autor:
Cecilia Astigiano, Andrea Benzi, Maria Elena Laugieri, Francesco Piacente, Laura Sturla, Lucrezia Guida, Santina Bruzzone, Antonio De Flora
Publikováno v:
Cells, Vol 11, Iss 17, p 2637 (2022)
ADP-ribosyl cyclases (ADPRCs) catalyze the synthesis of the Ca2+-active second messengers Cyclic ADP-ribose (cADPR) and ADP-ribose (ADPR) from NAD+ as well as nicotinic acid adenine dinucleotide phosphate (NAADP+) from NADP+. The best characterized A
Externí odkaz:
https://doaj.org/article/aed819e67ede4511896d966b5bd71735
Autor:
Andrea Benzi, Alessia Grozio, Sonia Spinelli, Laura Sturla, Andreas H. Guse, Antonio De Flora, Elena Zocchi, Joerg Heeren, Santina Bruzzone
Publikováno v:
Nutrients, Vol 13, Iss 11, p 3734 (2021)
Nicotinamide adenine dinucleotide (NAD+) is a fundamental molecule in the regulation of energy metabolism, representing both a coenzyme and a substrate for different NAD+ degrading enzymes. Among these enzymes, CD38 can be seen under two perspectives
Externí odkaz:
https://doaj.org/article/b813c71d7dcf4d43b273465e65e0095b
Autor:
Santina Bruzzone, Mirko Magnone, Elena Mannino, Giovanna Sociali, Laura Sturla, Chiara Fresia, Valeria Booz, Laura Emionite, Antonio De Flora, Elena Zocchi
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140588 (2015)
In recent years, Abscisic Acid (ABA) has been demonstrated to be involved in the regulation of glucose homeostasis in mammals as an endogenous hormone, by stimulating both insulin release and peripheral glucose uptake. In addition, ABA is released by
Externí odkaz:
https://doaj.org/article/bc82790b6d2e454db59e2aad73fb4dec
Autor:
Andrea, Benzi, Laura, Sturla, Markus, Heine, Alexander W, Fischer, Sonia, Spinelli, Mirko, Magnone, Giovanna, Sociali, Alessia, Parodi, Daniela, Fenoglio, Laura, Emionite, Friedrich, Koch-Nolte, Hans-Willi, Mittrücker, Andreas H, Guse, Antonio, De Flora, Elena, Zocchi, Joerg, Heeren, Santina, Bruzzone
Publikováno v:
Biochimica et biophysica acta. Molecular and cell biology of lipids. 1866(1)
Different strategies to boost NAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0761af265a965468855d50331287b62d
https://pubmed.ncbi.nlm.nih.gov/33010451
https://pubmed.ncbi.nlm.nih.gov/33010451
Autor:
Mirko Magnone 1, 2, Laura Emionite 3, Lucrezia Guida 1, Tiziana Vigliarolo 1, Laura Sturla 1, Sonia Spinelli 1, Ambra Buschiazzo 4, Cecilia Marini 4, 5, 6, Gianmario Sambuceti 4, Antonio De Flora 1, Anna Maria Orengo 4, Vanessa Cossu 4, Sara Ferrando 7, Ottavia Barbieri 3, Elena Zocchi 1.
Publikováno v:
Scientific reports (Nature Publishing Group) 10 (2020): 1454. doi:10.1038/s41598-020-58206-0
info:cnr-pdr/source/autori:Mirko Magnone 1,2, Laura Emionite 3, Lucrezia Guida 1, Tiziana Vigliarolo 1, Laura Sturla 1, Sonia Spinelli 1, Ambra Buschiazzo 4, Cecilia Marini 4,5,6, Gianmario Sambuceti 4,5,6, Antonio De Flora 1, Anna Maria Orengo 4, Vanessa Cossu 4, Sara Ferrando 7, Ottavia Barbieri 3, Elena Zocchi 1./titolo:Insulin-independent stimulation of skeletal muscle glucose uptake by low-dose abscisic acid via AMPK activation./doi:10.1038%2Fs41598-020-58206-0/rivista:Scientific reports (Nature Publishing Group)/anno:2020/pagina_da:1454/pagina_a:/intervallo_pagine:1454/volume:10
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
info:cnr-pdr/source/autori:Mirko Magnone 1,2, Laura Emionite 3, Lucrezia Guida 1, Tiziana Vigliarolo 1, Laura Sturla 1, Sonia Spinelli 1, Ambra Buschiazzo 4, Cecilia Marini 4,5,6, Gianmario Sambuceti 4,5,6, Antonio De Flora 1, Anna Maria Orengo 4, Vanessa Cossu 4, Sara Ferrando 7, Ottavia Barbieri 3, Elena Zocchi 1./titolo:Insulin-independent stimulation of skeletal muscle glucose uptake by low-dose abscisic acid via AMPK activation./doi:10.1038%2Fs41598-020-58206-0/rivista:Scientific reports (Nature Publishing Group)/anno:2020/pagina_da:1454/pagina_a:/intervallo_pagine:1454/volume:10
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Abscisic acid (ABA) is a plant hormone active also in mammals where it regulates, at nanomolar concentrations, blood glucose homeostasis. Here we investigated the mechanism through which low-dose ABA controls glycemia and glucose fate. ABA stimulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b764d313b39e82d9d78c7570bef374ae
http://www.cnr.it/prodotto/i/416488
http://www.cnr.it/prodotto/i/416488
