Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Antonio, Guarna"'
The dextrorotatory sweet asparagine of Arnaldo Piutti: the original product is conserved in Florence
Autor:
Laura Colli, Antonio Guarna
Publikováno v:
Substantia, Vol 2, Iss 2 (2018)
In 1886, Pasteur presented a note on the work of the Italian chemist Arnaldo Piutti concerning the difference between the two physical isomers (enantiomers) of asparagine. The octahedral crystal of asparagine appeared only as “levorotatory hemihedr
Externí odkaz:
https://doaj.org/article/54f524358ce64443963c26d3f99c30de
Publikováno v:
Molecules, Vol 19, Iss 10, Pp 16506-16528 (2014)
Chemical genetics is an approach for identifying small molecules with the ability to induce a biological phenotype or to interact with a particular gene product, and it is an emerging tool for lead generation in drug discovery. Accordingly, there is
Externí odkaz:
https://doaj.org/article/52aa40023aee4d2190957ca0bba77337
Autor:
Elena Lenci, Irene Stefanini, Antonio Guarna, Gloria Menchi, Duccio Cavalieri, Andrea Trabocchi
Publikováno v:
Proceedings, Vol 1, Iss 6, p 678 (2017)
Modern advances in Chemical Biology include the improvement of screening methods, the introduction of bioinformatic methods to unravel biological pathways, and the generation of highquality chemical libraries. [...]
Externí odkaz:
https://doaj.org/article/609aa7d2eb3a44a99bb576d0c6ab3ed9
Autor:
Andrea Trabocchi, Silvia Carbonell, Antonio Guarna, Duccio Cavalieri, Irene Stefanini, Marta Gut, Paul Bowyer, Damariz Rivero, Ivo Gut, Misha Kapushesky, Nagwa Ben Ghazzi, Lisa Rizzetto, Simon Heath
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports
Stefanini, I, Rizzetto, L, Rivero, D, Carbonell, S, Gut, M, Heath, S, Gut, I G, Trabocchi, A, Guarna, A, Ben Ghazzi, N, Bowyer, P, Kapushesky, M & Cavalieri, D 2018, ' Deciphering the mechanism of action of 089, a compound impairing the fungal cell cycle ', Scientific Reports, vol. 8, no. 1, 5964 . https://doi.org/10.1038/s41598-018-24341-y
Recercat. Dipósit de la Recerca de Catalunya
instname
Scientific Reports
Stefanini, I, Rizzetto, L, Rivero, D, Carbonell, S, Gut, M, Heath, S, Gut, I G, Trabocchi, A, Guarna, A, Ben Ghazzi, N, Bowyer, P, Kapushesky, M & Cavalieri, D 2018, ' Deciphering the mechanism of action of 089, a compound impairing the fungal cell cycle ', Scientific Reports, vol. 8, no. 1, 5964 . https://doi.org/10.1038/s41598-018-24341-y
Recercat. Dipósit de la Recerca de Catalunya
instname
Fungal infections represent an increasingly relevant clinical problem, primarily because of the increased survival of severely immune-compromised patients. Despite the availability of active and selective drugs and of well-established prophylaxis, cl
Autor:
Chiara Calugi, Antonio Guarna, Andrea Trabocchi, Francesca Bianchini, Jessica Ruzzolini, Gloria Menchi, Lido Calorini
Publikováno v:
MedChemComm. 6:277-282
A D-proline peptidomimetic targeting MMP-2 and MMP-9, being involved during tumor cell invasion and angiogenesis, was identified from a pool of compounds following enzyme inhibition kinetics and zymography, clearly highlighting the invasion inhibitor
Publikováno v:
European Journal of Organic Chemistry. 2014:7595-7604
Triazole-containing Arg-Gly-Asp (RGD) peptidomimetics capable of interacting with αvβ3 integrin were developed through click chemistry. The role of the diverse range of guanidine bioisosteres for the arginine mimetic moiety was evaluated in vitro t
Publikováno v:
Molecules, Vol 19, Iss 10, Pp 16506-16528 (2014)
Molecules
Molecules
Chemical genetics is an approach for identifying small molecules with the ability to induce a biological phenotype or to interact with a particular gene product, and it is an emerging tool for lead generation in drug discovery. Accordingly, there is
Autor:
Gloria Menchi, Mario Sechi, Nicolino Pala, Ilga Krimmelbein, Tobias Dreker, Antonio Guarna, Andrea Scozzafava, Fabrizio Carta, Andrea Trabocchi, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 30:466-471
The protein arginine deiminase 4 (PAD4) is a calcium-dependent enzyme, which catalyses the irreversible conversion of peptidyl-arginines into peptidyl-citrullines and plays an important role in several diseases such as in the rheumatoid arthritis, mu
Autor:
S. Raspanti, Pierangelo Fabbrizzi, Gloria Menchi, Francesca Bianchini, Andrea Trabocchi, Antonio Guarna
Publikováno v:
Tetrahedron. 70:5439-5449
Fragment-based drug discovery is a valuable tool in hit identification, as well as the combination of different small fragments showing a minimal binding activity against biological receptors or enzymes to give merged hits. A high number of fragments
Publikováno v:
European Journal of Medicinal Chemistry. 84:444-453
Small-molecule peptidomimetic inhibitors that already showed activity towards Secreted aspartic protease 2 as anti-Candida agents are herein presented as candidate HIV protease inhibitors. A library of 6,8-dioxa-3-azabicyclo[3.2.1]-octane peptidomime