Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Antonio, DiPasquale"'
Autor:
BinQing Wei, Kirk Robarge, Sharada S. Labadie, Jinhua Chen, Laura B. Corson, Antonio DiPasquale, Peter S. Dragovich, Charles Eigenbrot, Marie Evangelista, Benjamin P. Fauber, Anna Hitz, Rebecca Hong, Kwong Wah Lai, Wenfeng Liu, Shuguang Ma, Shiva Malek, Thomas O'Brien, Jodie Pang, David Peterson, Laurent Salphati, Deepak Sampath, Steven Sideris, Mark Ultsch, Zijin Xu, Ivana Yen, Dong Yu, Qin Yue, Aihe Zhou, Hans E. Purkey
Publikováno v:
Bioorganicmedicinal chemistry letters. 59
Structure-based design was utilized to optimize 6,6-diaryl substituted dihydropyrone and hydroxylactam to obtain inhibitors of lactate dehydrogenase (LDH) with low nanomolar biochemical and single-digit micromolar cellular potencies. Surprisingly the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0770db4a66cefb70bb9bee4bcf37ca52
https://pubmed.ncbi.nlm.nih.gov/35065235
https://pubmed.ncbi.nlm.nih.gov/35065235
Autor:
Brian S, Safina, Steven J, McKerrall, Shaoyi, Sun, Chien-An, Chen, Sultan, Chowdhury, Qi, Jia, Jun, Li, Alla Y, Zenova, Jean-Christophe, Andrez, Girish, Bankar, Philippe, Bergeron, Jae H, Chang, Elaine, Chang, Jun, Chen, Richard, Dean, Shannon M, Decker, Antonio, DiPasquale, Thilo, Focken, Ivan, Hemeon, Kuldip, Khakh, Amy, Kim, Rainbow, Kwan, Andrea, Lindgren, Sophia, Lin, Jonathan, Maher, Janette, Mezeyova, Dinah, Misner, Karen, Nelkenbrecher, Jodie, Pang, Rebecca, Reese, Shannon D, Shields, Luis, Sojo, Tao, Sheng, Henry, Verschoof, Matthew, Waldbrook, Michael S, Wilson, Zhiwei, Xie, Clint, Young, Tanja S, Zabka, David H, Hackos, Daniel F, Ortwine, Andrew D, White, J P, Johnson, C Lee, Robinette, Christoph M, Dehnhardt, Charles J, Cohen, Daniel P, Sutherlin
Publikováno v:
Journal of medicinal chemistry. 64(6)
Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d744b2a5894fa87236be1caf92c75b8b
https://pubmed.ncbi.nlm.nih.gov/33682420
https://pubmed.ncbi.nlm.nih.gov/33682420
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 1, Pp o242-o242 (2010)
The title compound, C12H13ClN6, was prepared by reaction of 4,5-dichloro-7H-pyrrolo[2,3-d]pyrimidine with 2-(1H-imidazol-4-yl)-N-methylethanamine, and the X-ray study confirmed that chloro-substituent in six-membered ring was replaced in the reaction
Externí odkaz:
https://doaj.org/article/f1a1b8ec1386414b83cf1a9c0771679e
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 12, Pp o3259-o3259 (2009)
The title compound, C9H7ClN2O2, was prepared by reaction of methyl 4-chloro-3-(prop-1-ynyl)picolinate with hydroxylamine in MeOH/KOH solution. The two essentially planar molecules which make up the asymmetric unit have almost identical geometries and
Externí odkaz:
https://doaj.org/article/f9c3cf689a00465a89ea8db855587d2d
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 10, Pp o2374-o2374 (2009)
The title compound, C12H19BrN4O, represents the minor component of the two products obtained in a series of transformations involving the Grignard reaction of tert-butoxycarbonyl-protected 4-aminocyclohexanone with MeMgBr, and subsequent interaction
Externí odkaz:
https://doaj.org/article/cafc96d911744c239c07171cb2e19624
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 6, Pp o1249-o1249 (2009)
The title compound, C9H12N4O4S, was proven to be the product of the reaction of methyl 5-amino-1H-pyrazole-3-carboxylate with ethyl isothiocyanatocarbonate. All non-H atoms of the molecule are planar, the mean deviation from the least squares plane b
Externí odkaz:
https://doaj.org/article/e3409e3586594cd6b557dcf11ef568fd
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 5, Pp o1089-o1089 (2009)
The title compound, C13H17N5OS, was obtained by cycloaddition of 2-[2-(methylsulfanyl)pyrimidin-4-yl]-3-oxopropanenitrile with (tetrahydrofuran-3-yl)hydrazine dihydrochloride and subsequent N-methylation of 4-[2-(methylsulfanyl)pyrimidin-4-yl]-1-(tet
Externí odkaz:
https://doaj.org/article/e1bc7a5eab4e47998b656704ffc7df93
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 4, Pp o870-o870 (2009)
The reaction of (E)-tert-butyl 4-[3-(dimethylamino)acryloyl]piperidine-1-carboxylate with methylhydrazine leads to the formation of the title compound, C14H23N3O2, with a 1-methyl-1H-pyrazol-5-yl substituent. The plane of the pyrazole ring forms a di
Externí odkaz:
https://doaj.org/article/ac02015f8ba04f1a98bb1f6ed478956f
Autor:
Zhengyu Liu, Kevin K.-C. Liu, Jeff Elleraas, Arnold L. Rheingold, Antonio DiPasquale, Alex Yanovsky
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 4, Pp o697-o697 (2009)
The title compound, C12H15N5OS, was obtained by reaction of 2-(2-(methylthio)pyrimidin-4-yl)-3-oxopropanenitrile with (tetrahydrofuran-3-yl)hydrazine dihydrochloride, and the racemic product was subsequently separated by chiral chromatography (first
Externí odkaz:
https://doaj.org/article/107453a2bc404692bb6d04bc2ac2e6f1
Autor:
Steven J, McKerrall, Teresa, Nguyen, Kwong Wah, Lai, Philippe, Bergeron, Lunbin, Deng, Antonio, DiPasquale, Jae H, Chang, Jun, Chen, Tania, Chernov-Rogan, David H, Hackos, Jonathan, Maher, Daniel F, Ortwine, Jodie, Pang, Jian, Payandeh, William R, Proctor, Shannon D, Shields, Jennifer, Vogt, Pengfei, Ji, Wenfeng, Liu, Elisa, Ballini, Lilia, Schumann, Glauco, Tarozzo, Girish, Bankar, Sultan, Chowdhury, Abid, Hasan, J P, Johnson, Kuldip, Khakh, Sophia, Lin, Charles J, Cohen, Christoph M, Dehnhardt, Brian S, Safina, Daniel P, Sutherlin
Publikováno v:
Journal of medicinal chemistry. 62(8)
Using structure- and ligand-based design principles, a novel series of piperidyl chromane arylsulfonamide Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::353b137470888081de078c0141a07409
https://pubmed.ncbi.nlm.nih.gov/30943032
https://pubmed.ncbi.nlm.nih.gov/30943032