Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Antonino N, Fallica"'
Autor:
Loredana Salerno, Luca Vanella, Valeria Sorrenti, Valeria Consoli, Valeria Ciaffaglione, Antonino N. Fallica, Vittorio Canale, Paweł Zajdel, Rosario Pignatello, Sebastiano Intagliata
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1377-1385 (2021)
In this work, the first mutual prodrug of 5-fluorouracil and heme oxygenase1 inhibitor (5-FU/HO-1 hybrid) has been designed, synthesised, and evaluated for its in vitro chemical and enzymatic hydrolysis stability. Predicted in silico physicochemical
Externí odkaz:
https://doaj.org/article/d08b3debd1ad442da383fcfbf840908f
Autor:
Agata Grazia D’Amico, Giuseppe Romeo, Velia D'Agata, Loredana Salerno, Antonio Rescifina, Sebastiano Intagliata, Valeria Consoli, Valeria Pittalà, Giuseppe Floresta, Antonino N. Fallica, Valeria Sorrenti, Luca Vanella
Publikováno v:
Journal of Medicinal Chemistry. 64:13373-13393
Heme oxygenase-1 (HO-1) promotes heme catabolism exercising cytoprotective roles in normal and cancer cells. Herein, we report the design, synthesis, molecular modeling, and biological evaluation of novel HO-1 inhibitors. Specifically, an amide linke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf40ba282c95b3b81206731b7af06a6
https://doi.org/10.1021/acs.jmedchem.1c00633
https://doi.org/10.1021/acs.jmedchem.1c00633
Autor:
Antonino N, Fallica, Valeria, Ciaffaglione, Maria N, Modica, Valeria, Pittalà, Loredana, Salerno, Emanuele, Amata, Agostino, Marrazzo, Giuseppe, Romeo, Sebastiano, Intagliata
Publikováno v:
Bioorganicmedicinal chemistry. 73
The overexpression of σ receptors (σRs) in various types of tumors has prompted a deep investigation of their role in cancer pathophysiology. Consequently, σR ligands have been widely studied in vitro and in vivo for their antiproliferative effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc262cdcb7fffa6f61a4897323f6aba8
https://pubmed.ncbi.nlm.nih.gov/36202063
https://pubmed.ncbi.nlm.nih.gov/36202063
Autor:
Antonino N. Fallica, Valeria Ciaffaglione, Maria N. Modica, Valeria Pittalà, Loredana Salerno, Emanuele Amata, Agostino Marrazzo, Giuseppe Romeo, Sebastiano Intagliata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b048462f8cc3051b09d0ed908481d0c2
https://hdl.handle.net/20.500.11769/540800
https://hdl.handle.net/20.500.11769/540800
Autor:
Antonio Rescifina, Loredana Salerno, Valeria Sorrenti, Antonino N. Fallica, Giuseppe Floresta, Valeria Pittalà
Publikováno v:
Bioorganic chemistry. 117
Up-regulation of HO-1 had been frequently reported in different cases and types of human malignancies. Since poor clinical outcomes are reported in these cases, this enzyme’s inhibition is considered a valuable and proven anticancer approach. To id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34a034bd24821502d4641e278db0d4d
https://pubmed.ncbi.nlm.nih.gov/34710668
https://pubmed.ncbi.nlm.nih.gov/34710668
Autor:
Mohamed Haider, Amr Elsherbeny, Maha Ali Alghamdi, Antonino N. Fallica, Khaled Greish, Valeria Pittalà
Enhanced permeation retention (EPR) was a significant milestone discovery by Maeda et al. paving the road for the emerging nanomedicine as a powerful tool in the fight against cancer. Sildenafil is a potent inhibitor of phosphodiesterase 5 (PDE-5) us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8fd852e70ff2fb20607bc5f6b662290
Autor:
Antonino N. Fallica, Valeria Pittalà, Maha Ali Alghamdi, Amr Elsherbeny, Khaled Greish, Mohamed Haider
Publikováno v:
Journal of Personalized Medicine
Journal of Personalized Medicine, Vol 11, Iss 585, p 585 (2021)
Journal of Personalized Medicine, Vol 11, Iss 585, p 585 (2021)
Enhanced permeation retention (EPR) was a significant milestone discovery by Maeda et al. paving the path for the emerging field of nanomedicine to become a powerful tool in the fight against cancer. Sildenafil is a potent inhibitor of phosphodiester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2125b615a1fafe153dc1162930fc175
https://pubmed.ncbi.nlm.nih.gov/34205602
https://pubmed.ncbi.nlm.nih.gov/34205602
Autor:
Giuseppe Romeo, Mohamed A. Helal, Maria N. Modica, Loredana Salerno, Agostino Marrazzo, Sebastiano Intagliata, Antonino N. Fallica, Valeria Pittalà
Publikováno v:
Journal of Medicinal Chemistry
Since their discovery as distinct receptor proteins, the specific physiopathological role of sigma receptors (σRs) has been deeply investigated. It has been reported that these proteins, classified into two subtypes indicated as σ1 and σ2, might p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4985022e50c23208360aa2724bb903
http://hdl.handle.net/20.500.11769/509366
http://hdl.handle.net/20.500.11769/509366
Autor:
Valeria Sorrenti, Loredana Salerno, Antonio Rescifina, Valeria Pittalà, Giuseppe Floresta, Antonino N. Fallica, Giuseppe Romeo
Publikováno v:
Bioorganic chemistry. 104
The enzymatic family of heme oxygenase (HO) is accountable for heme breakdown. Among the two isoforms characterized to date, HO-2 is poorly investigated due to the lack of potent HO-2 chemical modulators and the greater attentiveness towards HO-1 iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8106a503207d74fe263bc8a8f32b5602
https://pubmed.ncbi.nlm.nih.gov/33010625
https://pubmed.ncbi.nlm.nih.gov/33010625
Autor:
Valeria Ciaffaglione, Carmen Leonardi, Giuseppe Carota, Agostino Marrazzo, Valeria Pittalà, Emanuele Amata, Loredana Salerno, Sebastiano Intagliata, Giuseppe Romeo, Antonino N. Fallica
Heme oxygenase (HO) enzymes are involved in heme catabolism and several physiological functions. Among the different HO isoforms, HO-2 stands out for its neuroprotective properties and modulatory activity in male reproduction. However, unlike the HO-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed36303dace9c3a40b08d441293e3bf
http://hdl.handle.net/20.500.11769/374181
http://hdl.handle.net/20.500.11769/374181