Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Antonino B D'Assoro"'
Autor:
Mateusz Opyrchal, Jeffrey L Salisbury, Shuya Zhang, James McCubrey, John Hawse, Mattew P Goetz, Gwen A Lomberk, Tufia Haddad, Amy Degnim, Carol Lange, James N Ingle, Evanthia Galanis, Antonino B D'Assoro
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96995 (2014)
Development of endocrine resistance during tumor progression represents a major challenge in the management of estrogen receptor alpha (ERα) positive breast tumors and is an area under intense investigation. Although the underlying mechanisms are st
Externí odkaz:
https://doaj.org/article/c7da98dd6ce74f7c926be89deef9be93
Autor:
Eike-Benjamin Braune, Felix Geist, Xiaojia Tang, Krishna Kalari, Judy Boughey, Liewei Wang, Roberto A. Leon-Ferre, Antonino B. D’Assoro, James N. Ingle, Matthew P. Goetz, Julian Kreis, Kang Wang, Theodoros Foukakis, Anita Seshire, Dirk Wienke, Urban Lendahl
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-22 (2024)
Abstract Background Dysregulated Notch signalling contributes to breast cancer development and progression, but validated tools to measure the level of Notch signalling in breast cancer subtypes and in response to systemic therapy are largely lacking
Externí odkaz:
https://doaj.org/article/f8003a5a92c14e34b1fab373cd274d48
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 6241 (2022)
The Notch signaling pathway is an architecturally simple signaling mechanism, well known for its role in cell fate regulation during organ development and in tissue homeostasis. In keeping with its importance for normal development, dysregulation of
Externí odkaz:
https://doaj.org/article/feb2542b8986462590bbf4a874cbded3
Autor:
Alexey A. Leontovich, Mohammad Jalalirad, Jeffrey L. Salisbury, Lisa Mills, Candace Haddox, Mark Schroeder, Ann Tuma, Maria E. Guicciardi, Luca Zammataro, Mario W. Gambino, Angela Amato, Aldo Di Leonardo, James McCubrey, Carol A. Lange, Minetta Liu, Tufia Haddad, Matthew Goetz, Judy Boughey, Jann Sarkaria, Liewei Wang, James N. Ingle, Evanthia Galanis, Antonino B. D’Assoro
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-19 (2018)
Abstract Background Development of distant metastases involves a complex multistep biological process termed the invasion-metastasis cascade, which includes dissemination of cancer cells from the primary tumor to secondary organs. NOTCH developmental
Externí odkaz:
https://doaj.org/article/86a3724d1a17429ca5f5edb8bc06a69b
Autor:
Jeffrey L. Salisbury, Rajiv Kumar, Yun Niu, Ricardo G. Correa, Alysson R. Muotri, Nicholas Rowland, Antonino B. D'Assoro, Steven M. Mooney, Kelly Suino-Powell, Tieju Liu, Ilie D. Acu
Supplementary Figures 1-3 from Coordination of Centrosome Homeostasis and DNA Repair Is Intact in MCF-7 and Disrupted in MDA-MB 231 Breast Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93297a9dcea24a428322d4e2b7e41886
https://doi.org/10.1158/0008-5472.22387187
https://doi.org/10.1158/0008-5472.22387187
Autor:
Tufia C. Haddad, Vera J. Suman, Antonino B. D’Assoro, Jodi M. Carter, Karthik V. Giridhar, Brendan P. McMenomy, Katelyn Santo, Erica L. Mayer, Meghan S. Karuturi, Aki Morikawa, P. Kelly Marcom, Claudine J. Isaacs, Sun Young Oh, Amy S. Clark, Ingrid A. Mayer, Khandan Keyomarsi, Timothy J. Hobday, Prema P. Peethambaram, Ciara C. O’Sullivan, Roberto A. Leon-Ferre, Minetta C. Liu, James N. Ingle, Matthew P. Goetz
Publikováno v:
JAMA Oncology.
ImportanceAurora A kinase (AURKA) activation, related in part to AURKA amplification and variants, is associated with downregulation of estrogen receptor (ER) α expression, endocrine resistance, and implicated in cyclin-dependent kinase 4/6 inhibito
Autor:
Roberto A. Leon-Ferre, Antonino B. D'Assoro, Matthew Bidwell Goetz, Khandan Keyomarsi, Brendan P. McMenomy, Vera J. Suman, Ingrid A. Mayer, Amy S. Clark, Timothy J. Hobday, Claudine Isaacs, James N. Ingle, Tufia C. Haddad, Ciara C. O’Sullivan, Prema P. Peethambaram, Minetta C. Liu, Sun Young Oh, Aki Morikawa, Jodi M. Carter, Meghan Sri Karuturi, Karthik V. Giridhar, Erica L. Mayer, Paul K. Marcom
Publikováno v:
Cancer Research. 81:PD2-05
Background: In ER+ breast cancer (BC) models, Aurora A kinase (AURKA) activation is associated with expansion of CD44+/CD24low/- tumor initiating cells, down-regulation of ERα, and endocrine therapy resistance. Alisertib, a selective AURKA inhibitor
Autor:
Yuri Zakharov, Lev T. Perelman, Giuseppe Pettinato, Paul Kumar Upputuri, Robert A. Fisher, Umar Khan, Irving Itzkan, Liming Chen, Lei Zhang, Conor J. Sheil, Maria Glyavina, Mark F. Coughlan, Edward Vitkin, Le Qiu, Xuejun Zhang, Antonino B. D'Assoro
Publikováno v:
Science Advances
Formation of transplantable reproducible hiPSC organoids can be aided with real-time label-free intracellular spectroscopy.
Organoids formed from human induced pluripotent stem cells (hiPSCs) could be a limitless source of functional tissue for
Organoids formed from human induced pluripotent stem cells (hiPSCs) could be a limitless source of functional tissue for
Autor:
Kazuaki Takabe, Irwin H. Gelman, Malgorzata Gil, Antonino B. D'Assoro, Igor Puzanov, Thaer Khoury, Shipra Gandhi, Mateusz Opyrchal
Publikováno v:
Cancer Research. 79:P2-06
Background: Aurora A (AURKA) is a mitotic kinase responsible for centrosome segregation and mitotic spindle formation. In normal cells, expression of AURKA is highly regulated and is predominantly restricted to G2/M phases of the cell cycle. Unlike h
Autor:
Antonino B. D'Assoro
Publikováno v:
Cancer Research. 82:3163-3163
Purpose: Emergence of de novo or acquired resistance to standard of care endocrine therapies represents a major challenge in the clinical management of estrogen receptor alpha positive (ER+) breast tumors. This process is characterized by high tumor