Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Antonina Stefania Mangione"'
Autor:
Stephen P. Hunt, Michelangelo Certo, Maria Maiarù, Bazbek Davletov, Charlotte Leese, Antonina Stefania Mangione, Jason Arsenault, Irene Echeverria-Altuna
Publikováno v:
Science translational medicine. 10(450)
Chronic pain is a widespread debilitating condition affecting millions of people worldwide. Although several pharmacological treatments for relieving chronic pain have been developed, they require frequent chronic administration and are often associa
Autor:
G. Nappi, Tiziano Bandiera, Rosaria Greco, Giorgio Sandrini, Antonina Stefania Mangione, Francesca Siani, Cristina Tassorelli, Chiara Demartini, Andrea Armirotti, A Guijarro, Daniele Piomelli
Publikováno v:
Cephalalgia. 35:1065-1076
Background Systemic nitroglycerin (NTG) activates brain nuclei involved in nociceptive transmission as well as in neuroendocrine and autonomic functions in rats. These changes are considered relevant for migraine because NTG consistently provokes spo
Autor:
Rosaria Greco, Giacinto Bagetta, Giuseppe Nappi, Diana Amantea, Cristina Tassorelli, Michelangelo Certo, Giovanna Levandis, Fabio Blandini, Antonina Stefania Mangione
Publikováno v:
European Journal of Pharmacology. 744:91-97
The receptor for advanced glycation end products (RAGE) has a potential role as a damage-sensing molecule; however, to date, its involvement in the pathophysiology of stroke and its modulation following neuroprotective treatment are not completely un
Autor:
Antonina Stefania Mangione, Cristina Tassorelli, Rosaria Greco, Francesca Siani, G. Nappi, Fabio Blandini, G Sandrini, Maria Gabriella Buzzi, Mariapia Vairetti
Publikováno v:
Cephalalgia. 34:594-604
Background The release of calcitonin gene-related peptide (CGRP) from trigeminal nerves plays a central role in the pathophysiology of migraine and clinical evidence shows an antimigraine effect for CGRP receptor antagonists. Systemic administration
Autor:
Cristina Tassorelli, Fabio Blandini, Antonina Stefania Mangione, Rocco Gentile, Francesco Petrelli, Rosaria Greco, Diana Amantea, Giuseppe Nappi, M. Tiziana Corasaniti
Publikováno v:
Neurochemical Research. 37:1508-1516
Activation of RAGE (receptor for advanced glycation endproducts) and of its subtypes may play a role in neuronal damage and neuroinflammation associated with brain ischemia, though the underlying mechanisms remain unclear. In this study, we have exam
Autor:
Cristina Tassorelli, Giuseppe Nappi, Diana Amantea, Rosaria Greco, Antonina Stefania Mangione, Giacinto Bagetta
Publikováno v:
Brain Research. 1372:145-151
The role of nitric oxide (NO) in cerebral ischemia/reperfusion (IR) has been intensively investigated. In general NO is regarded as a mediator of ischemia-associated neuronal damage, as inhibitors of NO synthesis ameliorate neuronal injury during per
Autor:
M. Bolla, Marta Allena, Cristina Meazza, Antonina Stefania Mangione, Rosaria Greco, Giorgio Sandrini, Giuseppe Nappi, Hirocazu Mizoguchi, Diana Amantea, Cristina Tassorelli
Publikováno v:
Cephalalgia. 31:190-198
Background: Clinical studies indicated that nitric oxide (NO) donors cause regional changes in cerebral blood flow (CBF), similar to those reported in spontaneous migraine. Systemic nitroglycerin (NTG), a NO donor, is a well-accepted experimental mod
Autor:
Tiziano Bandiera, Cristina Tassorelli, Giuseppe Nappi, Giorgio Sandrini, Rosaria Greco, Daniele Piomelli, Antonina Stefania Mangione, Chiara Demartini
Publikováno v:
The Journal of Headache and Pain
Author(s): Greco, Rosaria; Bandiera, Tiziano; Mangione, Antonina S; Demartini, Chiara; Nappi, Giuseppe; Sandrini, Giorgio; Piomelli, Daniele; Tassorelli, Cristina
Autor:
Chiara Demartini, Giuseppe Nappi, Fabio Blandini, Rosaria Greco, Mariapia Vairetti, Antonina Stefania Mangione, Anna Maria Zanaboni, Cristina Tassorelli, Andrea Ferrigno
Publikováno v:
The Journal of Headache and Pain
Background Nitric oxide (NO) is known to play a key role in migraine pathogenesis, but modulation of NO synthesis has failed so far to show efficacy in migraine treatment. Asymmetric dimethylarginine (ADMA) is a NO synthase (NOS) inhibitor, whose lev
Autor:
Cristina Tassorelli, Antonina Stefania Mangione, Giuseppe Nappi, Rosaria Greco, Giorgio Sandrini
Publikováno v:
The Journal of Headache and Pain
Background Experimental animal models of migraine have suggested the existence of interactions between the endocannabinoid system and pain mediation in migraine. Extensive evidence has demonstrated a role for the cannabinoid-1 (CB1) receptor in antin