Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Antonina Klippert"'
Autor:
Mariana Neves, Antonina Klippert, Fanny Knöspel, Juliane Rudeck, Ailine Stolz, Zsofia Ban, Markus Becker, Kai Diederich, Barbara Grune, Pia Kahnau, Nils Ohnesorge, Johannes Pucher, Gilbert Schönfelder, Bettina Bert, Daniel Butzke
Publikováno v:
Journal of Biomedical Semantics, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Current animal protection laws require replacement of animal experiments with alternative methods, whenever such methods are suitable to reach the intended scientific objective. However, searching for alternative methods in the scientific li
Externí odkaz:
https://doaj.org/article/136f4476ca0443fba702bb7a53358b93
Autor:
Alexandre Laliberté, Caterina Prelli Bozzo, Christiane Stahl-Hennig, Victoria Hunszinger, Simone Joas, Ulrike Sauermann, Berit Roshani, Antonina Klippert, Maria Daskalaki, Kerstin Mätz-Rensing, Nicole Stolte-Leeb, Gregory K. Tharp, Dietmar Fuchs, Prachi Mehrotra Gupta, Guido Silvestri, Sydney A. Nelson, Laura Parodi, Luis Giavedoni, Steven E. Bosinger, Konstantin M.J. Sparrer, Frank Kirchhoff
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108351- (2023)
Summary: The accessory viral protein R (Vpr) is encoded by all primate lentiviruses. Vpr counteracts DNA repair pathways, modulates viral immune sensing, and induces cell-cycle arrest in cell culture. However, its impact in vivo is controversial. Her
Externí odkaz:
https://doaj.org/article/d97b01ec79264fde9d35d16bbbf8793a
Autor:
Simone Joas, Ulrike Sauermann, Berit Roshani, Antonina Klippert, Maria Daskalaki, Kerstin Mätz-Rensing, Nicole Stolte-Leeb, Anke Heigele, Gregory K. Tharp, Prachi Mehrotra Gupta, Sydney Nelson, Steven Bosinger, Laura Parodi, Luis Giavedoni, Guido Silvestri, Daniel Sauter, Christiane Stahl-Hennig, Frank Kirchhoff
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2261-2274.e7 (2020)
Summary: The inability of Nef to downmodulate the CD3-T cell receptor (TCR) complex distinguishes HIV-1 from other primate lentiviruses and may contribute to its high virulence. However, the role of this Nef function in virus-mediated immune activati
Externí odkaz:
https://doaj.org/article/03906fd8cd7840c89119e99657af1d0a
Publikováno v:
Animals, Vol 11, Iss 6, p 1789 (2021)
In the EU, the breeding of genetically modified laboratory animals is, by definition, an animal experiment if the offspring may experience pain, suffering, or harm. In order to determine the actual burden of genetically modified mice, established met
Externí odkaz:
https://doaj.org/article/52f96241ea8640d1979bbe32575b33c9
Publikováno v:
Animals, Vol 11, Iss 1789, p 1789 (2021)
Animals : an Open Access Journal from MDPI
Animals : an Open Access Journal from MDPI
Simple Summary In the EU, the breeding of genetically modified laboratory animals is defined as an animal experiment, if the animals may experience pain, suffering or harm due to the genetic modification. In most cases, modifications of the immune sy
Autor:
Berit Neumann, Maria Daskalaki, Christiane Stahl-Hennig, Franz-Josef Kaup, Kerstin Mätz-Rensing, Antonina Klippert
Publikováno v:
Journal of Medical Primatology. 46:144-148
Hallmarks of SIV infection are early depletion of gut CD4 T cells and diminished intestinal integrity. Comprehensive studies on colon biopsies of SIV-infected macaques efficiently controlling infection revealed that in contrast to viremic and failing
Autor:
Artur Kaul, Martina Bleyer, Ulrike Sauermann, Maria Daskalaki, Berit Neumann, Christiane Stahl-Hennig, Frank Kirchhoff, Antonina Klippert, Nicole Stolte-Leeb
Publikováno v:
Primate Biology, Vol 3, Iss 2, Pp 65-75 (2016)
Despite combination antiretroviral therapy, high-grade malignant non-Hodgkin's lymphoma (NHL) is still one of the most frequently acquired immunodeficiency syndrome (AIDS)-defining disorders in the end stage of infection with human immunodeficiency v
Autor:
Ahmad Kotb, Berit Neumann, Christiane Stahl-Hennig, Maria Daskalaki, Ulrike Sauermann, Antonina Klippert
Publikováno v:
Immunology & Cell Biology. 95:316-320
Granzyme B-expressing (GrB+) B cells are thought to contribute to immune dysfunctions in HIV patients, but so far their exact role is unknown. This report demonstrates for the first time the existence of GrB+ B cells in SIV-infected rhesus macaques,
Autor:
Sydney A. Nelson, Kerstin Mätz-Rensing, Christiane Stahl-Hennig, Simone Joas, Anke Heigele, Luis D. Giavedoni, Ulrike Sauermann, Daniel Sauter, Guido Silvestri, Antonina Klippert, Prachi Mehrotra Gupta, Berit Roshani, Frank Kirchhoff, Gregory K. Tharp, Laura M. Parodi, Maria Daskalaki, Steven E. Bosinger, Nicole Stolte-Leeb
Publikováno v:
Cell reports
Cell Reports, Vol 30, Iss 7, Pp 2261-2274.e7 (2020)
Cell Reports, Vol 30, Iss 7, Pp 2261-2274.e7 (2020)
SUMMARY The inability of Nef to downmodulate the CD3-T cell receptor (TCR) complex distinguishes HIV-1 from other primate lentiviruses and may contribute to its high virulence. However, the role of this Nef function in virus-mediated immune activatio
Publikováno v:
Journal of Immunological Methods. 433:59-68
Cryopreservation of peripheral blood mononuclear cells (PBMCs) is common for large clinical trials for which phenotypical characterization of lymphocytes is retrospectively performed in specialized core laboratories. It is therefore essential to asse