Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Antonie Rice"'
Autor:
Kelly E. Desino, Antonie Rice, Brandon J. Turunen, Richard H. Himes, Dinah Dutta, Jacquelyn K. Huff, Apurba Datta, Anna Seelig, Kenneth L. Audus, Jared T. Spletstoser, Gunda I. Georg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:495-498
A single-site modification of paclitaxel analogs at the C10 position on the baccatin III core that reduces interaction with P-glycoprotein in bovine brain microvessel endothelial cells is described. Modification and derivatization of the C10 position
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6599fb5d43288e77ef41297d67f4182a
https://doi.org/10.1016/j.bmcl.2005.10.063
https://doi.org/10.1016/j.bmcl.2005.10.063
Autor:
Richard H. Himes, Gunda I. Georg, Mary L. Michaelis, Antonie Rice, Yanbin Liu, Kenneth L. Audus
Publikováno v:
Journal of medicinal chemistry. 48(3)
The purpose of this work was to introduce a chemical modification into the paclitaxel (Taxol) structure to reduce interactions with the product of the multidrug resistant type 1 (MDR1) gene, P-glycoprotein (Pgp), resulting in improved blood-brain bar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4246787a4d3e41759bc17223cfe9d688
https://pubmed.ncbi.nlm.nih.gov/15689167
https://pubmed.ncbi.nlm.nih.gov/15689167
The blood–brain barrier (BBB) is composed of several components that serve to restrict the passage of compounds between the brain and systemic circulation. The monolayer of endothelial cells comprising the brain capillary is one of the primary comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad57627914be9f8cf9d63dd5e29275bd
https://doi.org/10.1016/b978-012639011-7/50009-7
https://doi.org/10.1016/b978-012639011-7/50009-7
Autor:
Per Alm, Eric Anderson, Susanne Angelow, Kenneth L. Audus, William A. Banks, Hannelore Bauer, Hans–Christian Bauer, David J. Begley, Ingolf E. Blasig, Albertus G. de Boer, Douwe D. Breimer, Thomas P. Davis, Prasanta Kumar Dey, Christine D. Dijkstra, Curtis E. Doberstein, John A. Duncan, Richard D. Egleton, Britta Engelhardt, Hans–Joachim Galla, Howard E. Gendelman, Takuji Igarashi, Conrad E. Johanson, Osamu Kakinohana, Abba J. Kastin, Gerd Krause, José V. Lafuente, Melanie Laschinger, Stefan Liebner, Nino Maida, Jozef Marsala, Martin Marsala, Paul N. McMillan, Linda J. Noble, Fred Nyberg, Donald E. Palm, Weihong Pan, Ranjana Patnaik, Gesa Rascher–Eggstein, Amit Kumar Ray, Antonie Rice, Lisa Ryan, Inez C.J. van der Sandt, Anke Schmidt, Hari Shanker Sharma, Peter Silverstein, Edward G. Stopa, Susan Swindells, Joho Tokumine, Andreas Traweger, Darkhan I. Utepbergenov, Peter Vajkoczy, Ivo Vanicky, Helga E. de Vries, Joachim Wegener, Jan Westman, Ken A. Witt, Hartwig Wolburg, Huangui Xiong, Jialin Zheng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc3da964969ff188be37487dfddc078d
https://doi.org/10.1016/b978-012639011-7/50000-0
https://doi.org/10.1016/b978-012639011-7/50000-0
Autor:
Gunda I. Georg, Yanbin Liu, Antonie Rice, Brandon J. Turunen, Kenneth L. Audus, Mary L. Michaelis
Publikováno v:
Journal of molecular neuroscience : MN. 20(3)
The blood-brain barrier (BBB) effectively prevents microtubule (MT)-stabilizing drugs from readily entering the central nervous system (CNS). A major limiting factor for microtubule-stabilizing drug permeation across the BBB is the active efflux back
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a9a21fa0d6675db1c3407b872a3ac5
https://pubmed.ncbi.nlm.nih.gov/14501017
https://pubmed.ncbi.nlm.nih.gov/14501017
Autor:
Gunda I. Georg, Emily A. Reiff, Yingxue Chen, Mary L. Michaelis, Sarah Hill, Antonie Rice, Kenneth L. Audus
Publikováno v:
Journal of molecular neuroscience : MN. 19(1-2)
Based on microtubule (MT) disruption observed in primary neurons exposed to fibrillar amyloid peptides (A beta), we tested the potential protective effect of MT-stabilizing drugs such as Taxol against A beta-induced disruption of the cytoskeleton. Al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2844df89e75d27afae2ea6b7cf597f
https://pubmed.ncbi.nlm.nih.gov/12212764
https://pubmed.ncbi.nlm.nih.gov/12212764