Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Antonia T. Destree"'
1
A Novel and Efficient Synthesis of a Highly Active Analogue of clasto-Lactacystin β-Lactone
Autor: Julian Adams, Teresa A. McCormack, Francois Soucy, Louis Grenier, Mark L. Behnke, Louis Plamondon, Antonia T. Destree
Publikováno v: Journal of the American Chemical Society. 121:9967-9976
Herein, we describe a new convergent synthesis of a more potent analogue of clasto-lactacystin β-lactone (2), PS-519 compound 4, which is currently in preclinical development for the treatment of i...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3784821bda3206f5a6c70e267b40fe2c
https://doi.org/10.1021/ja991175f
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2
Mechanistic Studies on the Inactivation of the Proteasome by Lactacystin in Cultured Cells
Autor: Antonia T. Destree, Louis Plamondon, Amy A. Cruikshank, Vito J. Palombella, Sandra L. Nunes, Lawrence R. Dick, Teresa A. McCormack, Lana A. Parent, Francesco D. Melandri, Ross L. Stein, Louis Grenier
Publikováno v: Journal of Biological Chemistry. 272:182-188
The natural product lactacystin exerts its cellular antiproliferative effects through a mechanism involving acylation and inhibition of the proteasome, a cytosolic proteinase complex that is an essential component of the ubiquitin-proteasome pathway
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105e4dbb3a199da226de46d1b25d9222
https://doi.org/10.1074/jbc.272.1.182
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4
A new model of cancer cachexia: contribution of the ubiquitin-proteasome pathway
Autor: Antonia T. Destree, Lawrence R. Dick, Michael B. Coggins, Stephen Brand, Bi Xu, Peter J. Elliott, Teresa A. McCormack, Alfred L. Goldberg, Laureen M. Mazzola, Margaret A. Read, Vered Solomon, Jacqueline W. Pierce, Douglas Lazarus, Jian Q. Huang
Publikováno v: The American journal of physiology. 277(2)
A new model of cachexia is described in which muscle protein metabolism related to the ubiquitin-proteasome pathway was investigated. Cloning of the colon-26 tumor produced a cell line, termed R-1, which induced cytokine (noninterleukin-1β, interleu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b274886c05f3b0222de63db1057527
https://pubmed.ncbi.nlm.nih.gov/10444430
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5
Inhibition of NF-κB activation in vitro and in vivo: Role of 26S proteasome
Autor: Julian Adams, Lana A. Parent, Peter J. Elliott, Henry Wong, Christine S. Pien, Vito J. Palombella, Antonia T. Destree, Stephen Brand, Laureen M. Mazzola, Elaine M. Conner, Matthew B. Grisham
Publikováno v: Methods in Enzymology ISBN: 9780121822019
It is becoming increasingly apparent that NF-kappa B plays a critical role in regulating the inflammatory response. Data obtained from studies in our laboratories demonstrate that the proteasome plays an important role in the inflammatory cascade by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::394beaf900d85b9253b2568aa1452535
https://doi.org/10.1016/s0076-6879(99)00140-8
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6
[39] Generation and analysis of vaccinia virus recombinants
Autor: Antonia T. Destree, Anna Mahr, Gail P. Mazzara
Publisher Summary This chapter presents methods for the generation and analysis of recombinant vaccinia viruses. Vaccinia virus is an extremely versatile virus expression system that can be easily manipulated in the laboratory. The widespread use of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b507f2a66e110de7daa2801c54c0969c
https://doi.org/10.1016/0076-6879(93)17089-n
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7
Intricate combinatorial patterns of exon splicing generate multiple regulated troponin T isoforms from a single gene
Autor: Antonia T. Destree, Vijak Mahdavi, Bernardo Nadal-Ginard, Hanh T. Nguyen, Roger E. Breitbart, Russell M. Medford
Publikováno v: Cell. 41:67-82
Mechanisms of alternative RNA splicing, important in the generation of protein diversity, are common but incompletely understood. Among the contractile proteins, troponin T exists in several isoforms, shown to be derived in part from a novel pattern
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1013056837eefd0ca12ecc92fccaeace
https://doi.org/10.1016/0092-8674(85)90062-5
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8
A novel mechanism of alternative RNA splicing for the developmentally regulated generation of troponin T isoforms from a single gene
Autor: Hanh T. Nguyen, Russell M. Medford, Antonia T. Destree, Bernardo Nadal-Ginard, Eric Summers
Publikováno v: Cell. 38:409-421
Troponin T (TnT) is a major regulatory protein of the striated muscle that exhibits developmental and tissue-specific structural heterogeneity. The molecular basis for this heterogeneity was studied at the level of TnT structural gene organization an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af89cc3dc7f09f3ba093d980f8891021
https://doi.org/10.1016/0092-8674(84)90496-3
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9
Selective depletion of chromosomes in a stable mouse-Chinese hamster hybrid cell line using antisera directed against species-specific cell surface antigens
Autor: Jeffrey J. Collins, Christopher J. Marshall, Ian Macpherson, Antonia T. Destree
Publikováno v: Journal of cellular physiology. 86(3 Pt 2)
A chromosomally-stable mouse-Chinese hamster hybrid cell line was subjected to five rounds of selection with cytotoxic antisera raised in rabbits against either the parental mouse 3T3 cells or the parental Chinese hamster Wg-1 cells. Routine karyolog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598894214fc2b8e9c6ec8b67aee4b975
https://pubmed.ncbi.nlm.nih.gov/1202037
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