Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Antonia Rotolo"'
Autor:
Keren Cheng, Yasunari Seita, Eoin C. Whelan, Ryo Yokomizo, Young Sun Hwang, Antonia Rotolo, Ian D. Krantz, Jill P. Ginsberg, Thomas F. Kolon, Priti Lal, Xunda Luo, Phillip M. Pierorazio, Rebecca L. Linn, Sandra Ryeom, Kotaro Sasaki
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114323- (2024)
Summary: Aberrant male germline development can lead to the formation of seminoma, a testicular germ cell tumor. Seminomas are biologically similar to primordial germ cells (PGCs) and many bear an isochromosome 12p [i(12p)] with two additional copies
Externí odkaz:
https://doaj.org/article/ff42fa80940b416a99ad55fe0bcb1f63
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
BackgroundChimeric antigen receptor-T (CAR-T) cells have transformed the treatment of human B cell malignancies. With the advent of CAR-T therapy, specific and in some cases severe toxicities have been documented with cytokine release syndrome (CRS)
Externí odkaz:
https://doaj.org/article/0117d45348934ecc9f26ef93915102d6
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100905- (2021)
Summary: Immunocompetent pet dogs develop spontaneous, human-like cancers, representing a parallel patient population for the investigation of chimeric antigen receptor (CAR) therapies. We have optimized a retrovirus-based protocol to efficiently CAR
Externí odkaz:
https://doaj.org/article/17a9bc7cbca04fab987aac4a7b7c56a1
Autor:
Nicola J. Mason, Nicholas Chester, Ailian Xiong, Antonia Rotolo, Ying Wu, Sho Yoshimoto, Patrick Glassman, Gayathri Gulendran, Don L. Siegel
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
The immune checkpoint inhibitor (ICI) ipilimumab has revolutionized the treatment of patients with different cancer histologies, including melanoma, renal cell carcinoma, and non-small cell lung carcinoma. However, only a subset of patients shows dra
Externí odkaz:
https://doaj.org/article/3d1a06698fe447c889e66b51ed9b5518
Publikováno v:
Revista Brasileira de Hematologia e Hemoterapia, Vol 30, Pp 24-29 (2008)
The introduction of the BCR-ABL kinase inhibitor, imatinib mesylate (Gleevec®, Novartis) led to significant changes in the treatment of chronic myeloid leukaemia (CML) patients. However, despite the impressive percentage of responding patients, some
Externí odkaz:
https://doaj.org/article/3fd204b282a44c3c8726006b3230182b
Autor:
Emanuela Messa, Sonia Carturan, Chiara Maffè, Marisa Pautasso, Enrico Bracco, Antonella Roetto, Francesca Messa, Francesca Arruga, Ilaria Defilippi, Valentina Rosso, Chiara Zanone, Antonia Rotolo, Elisabetta Greco, Rosa M. Pellegrino, Daniele Alberti, Giuseppe Saglio, Daniela Cilloni
Publikováno v:
Haematologica, Vol 95, Iss 8 (2010)
Background Usefulness of iron chelation therapy in myelodysplastic patients is still under debate but many authors suggest its possible role in improving survival of low-risk myelodysplastic patients. Several reports have described an unexpected effe
Externí odkaz:
https://doaj.org/article/f7fbab04fb544dbb84f3c3518933cf68
Autor:
Keisuke Watanabe, M. Angela Aznar, Shunichiro Kuramitsu, Mikko Siurala, Tong Da, Sangya Agarwal, Decheng Song, John Scholler, Antonia Rotolo, Avery D Posey, Alain H Rook, Paul L. Haun, Marco Ruella, Regina M. Young, Carl H June
Publikováno v:
Blood Advances.
A challenge when targeting T cell lymphoma with chimeric antigen receptor (CAR) T cell therapy is that target antigens are often shared between T cells and tumor cells, resulting in fratricide between CAR T cells and on-target cytotoxicity on normal
Publikováno v:
Cytotherapy. 22:53-56
Publikováno v:
Cancer Research. 82:1363-1363
Chimeric antigen receptor (CAR)-T cells targeting CD19 have revolutionized the treatment of B cell malignancies in people. However, post-treatment loss of CD19 has emerged as an adaptive mechanism of resistance. Pet dogs that develop tumors spontaneo
Autor:
Ailian Xiong, Patrick M. Glassman, Nicholas Chester, Don L. Siegel, Sho Yoshimoto, Ying Wu, Antonia Rotolo, Nicola J. Mason, Gayathri Gulendran
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The immune checkpoint inhibitor (ICI) ipilimumab has revolutionized the treatment of patients with different cancer histologies, including melanoma, renal cell carcinoma, and non-small cell lung carcinoma. However, only a subset of patients shows dra