Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Antonia P. Sagona"'
Autor:
Javier Sánchez Romano, Jaione Simón-Santamaría, Peter McCourt, Bård Smedsrød, Kim Erlend Mortensen, Antonia P. Sagona, Karen Kristine Sørensen, Anett Kristin Larsen
Publikováno v:
mSphere, Vol 9, Iss 3 (2024)
ABSTRACTPhage treatment has regained attention due to an increase in multiresistant bacteria. For phage therapy to be successful, phages must reach their target bacteria in sufficiently high numbers. Blood-borne phages are believed to be captured by
Externí odkaz:
https://doaj.org/article/322761b930ff4aa483fc0a61ede23986
Autor:
Sutthirat Sitthisak, Suphattra Manrueang, Supat Khongfak, Udomluk Leungtongkam, Rapee Thummeepak, Aunchalee Thanwisai, Nathan Burton, Gurneet K. Dhanoa, Panagiotis Tsapras, Antonia P. Sagona
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Phage lytic enzymes are promising antimicrobial agents. In this study, an endolysin derived from vB_AbaM_PhT2 (vPhT2), was identified. This endolysin represented the conserved lysozyme domain. Recombinant endolysin (lysAB- vT2) and hydrophob
Externí odkaz:
https://doaj.org/article/097b0079d1344ef9baa16be9559055e0
Autor:
Khushal Khambhati, Gargi Bhattacharjee, Nisarg Gohil, Gurneet K. Dhanoa, Antonia P. Sagona, Indra Mani, Nhat Le Bui, Dinh‐Toi Chu, Janardhan Keshav Karapurkar, Su Hwa Jang, Hee Yong Chung, Rupesh Maurya, Khalid J. Alzahrani, Suresh Ramakrishna, Vijai Singh
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 2, Pp n/a-n/a (2023)
Abstract Antibiotic resistance ranks among the top threats to humanity. Due to the frequent use of antibiotics, society is facing a high prevalence of multidrug resistant pathogens, which have managed to evolve mechanisms that help them evade the las
Externí odkaz:
https://doaj.org/article/26578e2808e541d9bda93e00a4d03500
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Escherichia coli is one of the most common Gram-negative pathogens and is responsible for infection leading to neonatal meningitis and sepsis. The FtsZ protein is a bacterial tubulin homolog required for cell division in most species, including E. co
Externí odkaz:
https://doaj.org/article/d50f413b61ea443ba63c2e9a739ea6bd
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT Reviewing the genetics underlying the arms race between bacteria and bacteriophages can offer an interesting insight into the development of bacterial resistance and phage co-evolution. This study shows how the natural development of resista
Externí odkaz:
https://doaj.org/article/665115ab3fb144b98f29dd41cdee2140
Autor:
Panagiotis Tsapras, Stavroula Petridi, Selina Chan, Marta Geborys, Anne-Claire Jacomin, Antonia P. Sagona, Pascal Meier, Ioannis P. Nezis
Publikováno v:
Cell Reports, Vol 38, Iss 4, Pp 110286- (2022)
Summary: Selective autophagy is a catabolic route that turns over specific cellular material for degradation by lysosomes, and whose role in the regulation of innate immunity is largely unexplored. Here, we show that the apical kinase of the Drosophi
Externí odkaz:
https://doaj.org/article/7bcd2a950cbc4ddd993881f146b2b3de
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Phage therapy, the therapeutic usage of viruses to treat bacterial infections, has many theoretical benefits in the ‘post antibiotic era.’ Nevertheless, there are currently no approved mainstream phage therapies. One reason for this is a lack of
Externí odkaz:
https://doaj.org/article/56d2b60590a144cda5c60fef43d5ed8f
Autor:
Ákos Avramucz, Christian Møller-Olsen, Aurelija M. Grigonyte, Yanahan Paramalingam, Andrew Millard, Antonia P. Sagona, Tamás Fehér
Publikováno v:
Biology, Vol 10, Iss 6, p 556 (2021)
The recognition and binding of host bacteria by bacteriophages is most often enabled by a highly specific receptor–ligand type of interaction, with the receptor-binding proteins (RBPs) of phages being the primary determinants of host specificity. S
Externí odkaz:
https://doaj.org/article/b461611b3aa349ee8382f77b631f4e84
Autor:
Kathryn M. Styles, Rapee Thummeepak, Udomluk Leungtongkam, Sophie E. Smith, Gabrielle S. Christie, Andrew Millard, John Moat, Christopher G. Dowson, Elizabeth M. H. Wellington, Sutthirat Sitthisak, Antonia P. Sagona
Publikováno v:
Antibiotics, Vol 9, Iss 4, p 200 (2020)
The multi-drug resistance of the opportunistic pathogen Acinetobacter baumannii is of growing concern, with many clinical isolates proving to be resistant to last resort as well as front line antibiotic treatments. The use of bacteriophages is an att
Externí odkaz:
https://doaj.org/article/78f4a049dfc84ffaa8f205605a66d9ed
Autor:
Aurelija M. Grigonyte, Christian Harrison, Paul R. MacDonald, Ariadna Montero-Blay, Matthew Tridgett, John Duncan, Antonia P. Sagona, Chrystala Constantinidou, Alfonso Jaramillo, Andrew Millard
Publikováno v:
Viruses, Vol 12, Iss 2, p 193 (2020)
With the recent rise in interest in using lytic bacteriophages as therapeutic agents, there is an urgent requirement to understand their fundamental biology to enable the engineering of their genomes. Current methods of phage engineering rely on homo
Externí odkaz:
https://doaj.org/article/a84596f1b43046f89302afbc90644b8e