Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Antonia Nikitenko"'
Autor:
Dane M. Springer, John R. Potoski, Chan Anita Wai-Yin, Roger Farr, Mousumi Ghosh, Sam Tadayon, Terrence J. Connolly, Antonia Nikitenko, Michael F. MacEwan, Anthony F. Kreft, Gregg Feigelson, Douglas M. Ho, Xinxu Shi, Asaf Alimardanov, Ren Jianxin, Eric G. Hansen, Zhixian Ding
Publikováno v:
Organic Process Research & Development. 13:1161-1168
Development of a large-scale enantioselective synthesis of a lead compound containing a 3-aryl-3-trifluoromethyl-2-aminopropanol core is described. A single isomer of 3,3-disubstituted acrylic acid derivative was prepared via Perkin condensation or H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b4e49fabfdfa759f491b0e0bcd96722
https://doi.org/10.1021/op900216v
https://doi.org/10.1021/op900216v
Autor:
Ren Jianxin, Gontcharov Alexander, John R. Potoski, Zhixian Ding, Asaf Alimardanov, Paige E. Mahaney, Casey Cameron Mccomas, Antonia Nikitenko, Joseph Ashcroft, Mousumi Ghosh, Panolil Raveendranath, Levent Mahmut, Chan Anita Wai-Yin, Maotang Zhou
Publikováno v:
Organic Process Research & Development. 13:880-887
Development of a scalable synthesis of WAY-315193 is described. Use of LiHMDS as a base and Ti(O-i-Pr)4 as a Lewis acid was optimal for efficient and reproducible addition of indolinone anion to epoxyalcohol. Conversion of indolinone diol to indolino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::999ca2acb0b5d4027551d44f8585a793
https://doi.org/10.1021/op900141r
https://doi.org/10.1021/op900141r
Autor:
Asaf Alimardanov, Nicole T. Hatzenbuhler, Steve Lenicek, Livia Kristofova, Deborah Ann Evrard, Afragola Jay Thomas, Antonia Nikitenko, Gary Paul Stack, Jean Schmid, Vasilios Marathias, John R. Potoski
Publikováno v:
Organic Process Research & Development. 13:91-97
An alternative synthesis of WAY-262398, 1, a novel, dual-acting SSRI/5-HT1A antagonist, has been developed. The target compound was initially synthesized as a part of diastereomeric mixture which was separated by chiral preparative HPLC. The new rout
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::188865e104ad8fb99427553d8d459b42
https://doi.org/10.1021/op8002085
https://doi.org/10.1021/op8002085
Autor:
Annmarie Louise Sabb, John R. Potoski, Deborah Ann Evrard, Gary Paul Stack, Mairead Young, Robert Lewis Vogel, Melissa Lin, Boyd L. Harrison, Antonia Nikitenko
Publikováno v:
Organic Process Research & Development. 12:76-80
An alternative synthesis of WAY-253752, 1, a novel, dual-acting SSRI/5HT1A antagonist, was developed and used for the first scale-up. Initially, the target compound was synthesized as part of a diasteromeric mixture separated by chiral preparative HP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a9164c2fee886f29d0336e777cd8109
https://doi.org/10.1021/op700181n
https://doi.org/10.1021/op700181n
Autor:
Antonia Nikitenko, George A. Ellestad, Anna Gazumyan, Vladimir I. Razinkov, Girija Krishnamurthy
Publikováno v:
Chemistry & Biology. 8:645-659
Background: RFI-641, a small dendrimer-like compound, is a potent and selective inhibitor of respiratory syncytial virus (RSV), which is currently a clinical candidate for the treatment of upper and lower respiratory tract infections caused by RSV. R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b15c40aba42b1881181268b7b17da40
https://doi.org/10.1016/s1074-5521(01)00042-4
https://doi.org/10.1016/s1074-5521(01)00042-4
Autor:
Antonia Nikitenko, Asaf Alimardanov, Jay Afragola, Jean Schmid, Livia Kristofova, Deborah Evrard, Nicole T. Hatzenbuhler, Vasilios Marathias, Gary Stack, Steve Lenicek, John Potoski
Publikováno v:
Organic Process Research & Development; Jan2009, Vol. 13 Issue 1, p91-97, 7p
Autor:
Antonia Nikitenko, Deborah Evrard, Annmarie L. Sabb, Robert L. Vogel, Gary Stack, Mairead Young, Melissa Lin, Boyd L. Harrison, John R. Potoski
Publikováno v:
Organic Process Research & Development; Dec2007, Vol. 12 Issue 1, p76-80, 5p