Haploinsufficiency for translation elongation factor eEF1A2 in aged mouse muscle and neurons is compatible with normal function.

Autor: Lowri A Griffiths, Jennifer Doig, Antonia M D Churchhouse, Faith C J Davies, Charlotte E Squires, Helen J Newbery, Catherine M Abbott

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e41917 (2012)

Translation elongation factor isoform eEF1A2 is expressed in muscle and neurons. Deletion of eEF1A2 in mice gives rise to the neurodegenerative phenotype "wasted" (wst). Mice homozygous for the wasted mutation die of muscle wasting and neurodegenerat

Externí odkaz: https://doaj.org/article/ece3cf6673794b6fbab4c8e83e32bd3d

Inflammatory Bowel Disease-Associated Colorectal Cancer: Translational Risks from Mechanisms to Medicines

Autor: Shahida Din, Ross J Porter, Antonia M. D. Churchhouse, Mark J. Arends

Publikováno v: Journal of Crohn's & Colitis
Porter, R J, Arends, M J, Churchhouse, A M D & Din, S 2021, ' Inflammatory bowel disease-associated colorectal cancer: translational risks from mechanisms to medicines ', Journal of Crohn's and Colitis . https://doi.org/10.1093/ecco-jcc/jjab102

The cumulative impact of chronic inflammation in patients with inflammatory bowel diseases predisposes to the development of inflammatory bowel disease-associated colorectal cancer [IBD-CRC]. Inflammation can induce mutagenesis, and the relapsing–r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a416819d46379a10c031b90b4671a4
https://pubmed.ncbi.nlm.nih.gov/34111282

PWE-045 Vedolizumab results in reduced hospitalisation and steroid use over 1-year:results from the scottish vedolizumab cohort

Autor: Daniel R. Gaya, P Shasi, D Watts, Charlie W. Lees, P Baker, H Jafferbhoy, C Mowat, Emma Donoghue, John Paul Seenan, Andrea K Watson, Graham Naismith, E Saffouri, Morag MacMaster, John Todd, Nikolas Plevris, Max Groome, Phil Jenkinson, L Potts, Cher Chuah, Alan G. Shand, Colin L. Noble, Antonia M. D. Churchhouse, Jonathan Macdonald, Eleanor F Watson, J Veryan, A Sengupta, Paul Brennan, Shahida Din, R Allen, I. D. R. Arnott, G R Jones

Publikováno v: IBD.

Introduction The GEMINI trials and an increasing body of real-world data have demonstrated the effectiveness and safety of vedolizumab (VDZ) in IBD. However, there is limited available data about its effect on hospitalisations and steroid use. Our ai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a262bbd8a13cb16d3bbd55614f40c405
https://doi.org/10.1136/gutjnl-2018-bsgabstracts.177

Implications of lowering threshold of plasma troponin concentration in diagnosis of myocardial infarction:cohort study

Autor: Simon Walker, Antonia M. D. Churchhouse, Mary Stoddart, Kuan Ken Lee, David E. Newby, Margaret MacLeod, Martin A. Denvir, David A. McAllister, Keith A.A. Fox, Nicholas L. Mills

Publikováno v: Mills, N L, Lee, K K, McAllister, D A, Churchhouse, A M D, Macleod, M, Stoddart, M, Walker, S, Denvir, M A, Fox, K A A & Newby, D E 2012, ' Implications of lowering threshold of plasma troponin concentration in diagnosis of myocardial infarction : cohort study ', British Medical Journal (BMJ), vol. 344, no. 7852, e1533 . https://doi.org/10.1136/bmj.e1533

ObjectiveTo assess the relation between troponin concentration, assay precision, and clinical outcomes in patients with suspected acute coronary syndrome.DesignCohort study.SettingTertiary centre in Scotland.Participants2092 consecutive patients admi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f1b422dbbaa134acacf385a18e6b88
https://www.pure.ed.ac.uk/ws/files/8109056/Implications_of_lowering_threshold_of_plasma_troponin_concentration_in_diagnosis_of_myocardial_infarction.pdf

OC-002 Predicting Outcome In Acute Ulcerative Colitis: Comparison Of The Travis And Ho Scores Using Uk Ibd Audit Data

Autor: Ruairi Lynch, I. D. R. Arnott, Antonia M. D. Churchhouse, A. Protheroe

Publikováno v: Gut. 63:A1.2-A2

Introduction Patients with severe Ulcerative Colitis (UC) are commonly identified using the Truelove and Witts 1 criteria on presentation. The Travis 2 and Ho 3 scores are subsequently used to identify patients with severe UC who are at high risk of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c493065115eabeff6848e0fb99041cc
https://doi.org/10.1136/gutjnl-2014-307263.2