Výsledky vyhledávání - "Antonia Germani"

Akademický článek

HMGB1-mediated apoptosis and autophagy in ischemic heart diseases

Autor: Eleonora Foglio, Laura Pellegrini, Antonia Germani, Matteo Antonio Russo, Federica Limana

Publikováno v: Vascular Biology, Vol 1, Iss 1, Pp H89-H96 (2019)

Acute myocardial infarction (MI) and its consequences are the most common and lethal heart syndromes worldwide and represent a significant health problem. Following MI, apoptosis has been generally seen as the major contributor of the cardiomyocyte f

Externí odkaz: https://doaj.org/article/9e63c44dad2e4d8ea925ba33435ee09d

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Akademický článek

HMGB1 attenuates cardiac remodelling in the failing heart via enhanced cardiac regeneration and miR-206-mediated inhibition of TIMP-3.

Autor: Federica Limana, Grazia Esposito, Daniela D'Arcangelo, Anna Di Carlo, Sveva Romani, Guido Melillo, Antonella Mangoni, Chiara Bertolami, Giulio Pompilio, Antonia Germani, Maurizio C Capogrossi

Publikováno v: PLoS ONE, Vol 6, Iss 6, p e19845 (2011)

AIMS: HMGB1 injection into the mouse heart, acutely after myocardial infarction (MI), improves left ventricular (LV) function and prevents remodeling. Here, we examined the effect of HMGB1 in chronically failing hearts. METHODS AND RESULTS: Adult C57

Externí odkaz: https://doaj.org/article/f454ff3798674e07926ac8524f8ff21a

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HMGB1 and repair: focus on the heart

Autor: Matteo Antonio Russo, Antonia Germani, Federica Limana, Laura Pellegrini, Elena Pontemezzo, Eleonora Foglio

Publikováno v: Pharmacology & Therapeutics. 196:160-182

High-mobility group box 1 (HMGB1) is one of the most abundant proteins in eukaryotes and the best characterized damage-associated molecular pattern (DAMP). The biological activities of HMGB1 depend on its subcellular location, context and post-transl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d11de7ab0ca7a025501f3b5999fddc
https://doi.org/10.1016/j.pharmthera.2018.12.005

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The Nucleolar Protein Nucleophosmin Is Physiologically Secreted by Endothelial Cells in Response to Stress Exerting Proangiogenic Activity Both In Vitro and In Vivo

Autor: Roberta Melchionna, Mario Picozza, Marco D'Agostino, Sara Beji, Silvia Palmerio, Alessandra Magenta, Antonia Germani, Anna Di Carlo, Daniele Avitabile, Elena De Falco, Vincenzo Petrozza

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 3672, p 3672 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 7

Nucleophosmin (NPM), a nucleolar multifunctional phosphoprotein, acts as a stress sensor in different cell types. NPM can be actively secreted by inflammatory cells, however its biology on endothelium remains unexplored. In this study, we show for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3616fd8cde30911968e9c0c821e615c5
https://www.mdpi.com/1422-0067/22/7/3672

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Cardiac Repair: The Intricate Crosstalk between the Epicardium and the Myocardium

Autor: Antonia Germani, Matteo Antonio Russo, Elena Pontemezzo, Federica Limana, Eleonora Foglio, Laura Pellegrini

Publikováno v: Current stem cell researchtherapy. 15(8)

Background: Substantial evidences support the hypothesis that the epicardium has a role in cardiac repair and regeneration in part providing, by epithelial to mesenchymal transition (EMT), progenitor cells that differentiate into cardiac cell types a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e0a009267cd4290e3d9b8fd7bec4e9
https://pubmed.ncbi.nlm.nih.gov/32072905

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HMGB1-mediated apoptosis and autophagy in ischemic heart diseases

Autor: Matteo Antonio Russo, Antonia Germani, Laura Pellegrini, Eleonora Foglio, Federica Limana

Publikováno v: Vascular Biology, Vol 1, Iss 1, Pp H89-H96 (2019)
Vascular Biology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f6d486541c624db4f3a0dfc4d39660
https://vb.bioscientifica.com/view/journals/vb/1/1/VB-19-0013.xml

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miR-200c-3p Regulates Epitelial-to-Mesenchymal Transition in Epicardial Mesothelial Cells by Targeting Epicardial Follistatin-Related Protein 1

Autor: Federico Bussolino, Federica Limana, Elena Astanina, Eleonora Foglio, Matteo Antonio Russo, Antonia Germani, Marco D'Agostino, Elena Pontemezzo, Alessandra Magenta, Enza Vernucci, Sara Sileno, Laura Pellegrini

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 4971, p 4971 (2021)
International Journal of Molecular Sciences
International journal of molecular sciences
22 (2021). doi:10.3390/ijms22094971
info:cnr-pdr/source/autori:Pontemezzo E.; Foglio E.; Vernucci E.; Magenta A.; D'agostino M.; Sileno S.; Astanina E.; Bussolino F.; Pellegrini L.; Germani A.; Russo M.A.; Limana F./titolo:Mir-200c-3p regulates epitelial-to-mesenchymal transition in epicardial mesothelial cells by targeting epicardial follistatin-related protein 1/doi:10.3390%2Fijms22094971/rivista:International journal of molecular sciences (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:22
Volume 22
Issue 9

Recent findings suggest that epithelial to mesenchymal transition (EMT), a key step during heart development, is involved in cardiac tissue repair following myocardial infarction (MI). MicroRNAs (miRNAs) act as key regulators in EMT processes
ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::630ca743122cda52dc479e5b2ae8c983
https://doi.org/10.3390/ijms22094971

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HMGB1 Inhibits Apoptosis Following MI and Induces Autophagy via mTORC1 Inhibition

Autor: Matteo Antonio Russo, Federica Limana, Eleonora Foglio, Giovanni Puddighinu, Antonia Germani

Publikováno v: Journal of Cellular Physiology. 232:1135-1143

Exogenous High Mobility Group Box-1 protein (HMGB1) has been reported to protect the infarcted heart but the underlying mechanism is quite complex. In particular, its effect on ischemic cardiomyocytes has been poorly investigated. Aim of the present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9db956a57d141a9f76efb19ca3717f8
https://doi.org/10.1002/jcp.25576

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